DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and Y113G7C.1

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_507918.1	Gene:	Y113G7C.1 / 180332	WormBaseID:	WBGene00013771	Length:	1494	Species:	Caenorhabditis elegans

Alignment Length:	904	Identity:	173/904 - (19%)
Similarity:	295/904 - (32%)	Gaps:	296/904 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKF-TILPARTSSGAAIALFTANRHSPLSVSHTT 202
            |:.:|...|.|......:.|::.  .|.::.||| .::.|.|.....:...||:  |.|......
Worm   627 SIEQQINHINLGNLESTLLPNLN--NSFMENGKFKDVISAETKVSECLQNLTAD--SLLVTQAIA 687

  Fly   203 TLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLS--QKILTLLKGGYPARLKKVLIV 265
            |::.: .:||..|.:|..|.|          :..:.|...|:  :||...:|       |.|..|
Worm   688 TIRKL-RKLDDKLLESVQQTA----------TSVAQFSATLASIEKIPDTMK-------KNVKNV 734

  Fly   266 TAPL--W----------------FKAPFKILRLFVREKLRERVFTV---SVPQLALHVPRKALPI 309
            |..|  |                .:..|.:|.|.....|.:.|..:   .:.::.....:|.|..
Worm   735 TLELNKWSQSLNQSDAITHSASALRGVFGLLELESSIGLLKDVDAIVSGEIAKVQATEDQKRLKT 799

  Fly   310 HLGGTLEVDHATWL------------------LSCRQSMTNREDELLANIVGVGGGSGSGSAAGS 356
            ..|     ||.|.:                  :|..|::||....|:                ..
Worm   800 QWG-----DHKTDMASLDAAIVKADAFVKKIDVSMAQTLTNYSAPLM----------------DL 843

  Fly   357 AAIVSTNGTETEAATTAATIISAVHQLG-------DNNTTVV---TVSNGVGPAGSASGGATTAA 411
            |||...|....|.:.....:||.:..:|       |..|.::   .|.:.:..........|:..
Worm   844 AAIPDVNINALEKSKVLEKLISLMPPVGRKRRAAADPKTQLIAAKAVLDQLAALDLKFSSGTSGV 908

  Fly   412 SAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAG 476
            ..|.:...|:.....:..|..|..:||.:|           :.|.|....:....:.:.....:|
Worm   909 QTAFKSFSNVLTKFFATQHISAPPSSSGNS-----------VGTGGGGTGSGGTGSDSGGESGSG 962

  Fly   477 AAAGTTTNG--------------------------------GG---------EFWSENPPSSASS 500
            :|||.|:.|                                ||         |...|......:.
Worm   963 SAAGKTSGGSSPVNKRKEPVDFPTLAVVIPLVAMLLAGVAIGGFLFRQHKIHEKDREEEKKRKTQ 1027

  Fly   501 GFSD----------------------------------------------------DDSLAGQEG 513
            .|.|                                                    :|:...:|
Worm  1028 DFQDQQDADIERAEADEQRRKMNVERAKKDEERAKKDKRDAEERRKKDEERAKKDKEDAKKAKE- 1091

  Fly   514 DPKPIDQIVQMVKQRGRHGL-------------IKEYADI----RNRAPE--------------- 546
            |.:.||::...||:|....|             :||..|:    :.||.|
Worm  1092 DQEKIDKLAAEVKEREEKSLARHEKEEEDEKRRLKEEEDVKQLNKERAMEREEQLIGDMKVWIIS 1156

  Fly   547 ---------GTFLHARM---------RANLT---------KNRYTDVLCYDHSRVVLAHEDGDEP 584
                     ..|.:|.|         :.|:|         |:||..|.|...:.|.:.......|
Worm  1157 QDHQDADKTARFYNATMDQVYVTTLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVP 1221

  Fly   585 SDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPT 649
               |:||::..:...:.:|:|||||..|.:|||.|....:...|.|....:|:...||..|:...
Worm  1222 ---IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASD 1283

  Fly   650 EESSLEFGDYHVRTISVE--CNEDYMVASLELRNIKTD-EIRNVSHWQFTSWPDYGVPSSAMAML 711
            ..|.|:.|.:.:.|.|.:  ..::.:...|.:::.... |.:.|:|:|...|||...|.:.:...
Worm  1284 PPSKLDIGRFQITTQSRQLILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTF 1348

  Fly   712 NFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGT 776
            ..::.|::.:                 .|||||||||||||..||..:.....:|:....::...
Worm  1349 ELMELVKKSE-----------------NPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEA 1396

  Fly   777 VEKIRSQRAYSIQMPDQYVFCHLALI-----EYAYSRGM----LQTVD-----LAGFDE 821
            ::.:|..|...:||..|..:..|..:     ||.::..|    ::..|     |||:::
Worm  1397 LKHLREHRWKGVQMRSQLYWMTLGAVYRLIREYNFNMRMHTDLMKDFDRVVELLAGYEK 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	1/4 (25%)
		SEC14	170..314	CDD:238099	35/167 (21%)
		Y_phosphatase	557..803	CDD:278528	66/262 (25%)
		PTPc	559..803	CDD:238006	65/260 (25%)
Y113G7C.1	NP_507918.1	WSN	172..239	CDD:197734
		MAP7	1015..1145	CDD:283355	19/130 (15%)
		Y_phosphatase	1194..1426	CDD:278528	64/251 (25%)
		PTPc	1196..1428	CDD:238006	64/251 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_2QR81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810