DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and ptp-5.1

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_500733.2	Gene:	ptp-5.1 / 177291	WormBaseID:	WBGene00016053	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	88/467 - (18%)
Similarity:	156/467 - (33%)	Gaps:	114/467 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 GSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSA------ 459
            |.....|:.....||:||...|.....||............::.:..|..:|......|
Worm    18 GKLMSTASRNGDEATKPNGTKTSKKRKPSRGNDDKGREPEPTAQSKKAKKMKPKRDSKAPSPALS 82

  Fly   460 --------DNNSTITNATTAAGAAGAAAGTTTN----------------------------GGGE 488
                    |...|:.:....|..|.:.:||.|:                            |...
Worm    83 PGPREQLSDQKKTVEDDPPPAPIATSVSGTVTSTVNAMPAILSSEVSNKQPKEVNSMKKTKGAPN 147

  Fly   489 FWSENPPSSASSGFSDDDSLAGQEGDPKPIDQI-VQMVKQRGRHGLIKEYADIRNRAPEGTFLHA 552
            ..::.|.|..:|...:.|...|::.....:|.| :..||        |::..::....:......
Worm   148 STTDTPVSHKTSITGNADKWVGEDVAKTWMDSIDLAEVK--------KDFEKLQTMKIDIDKDCK 204

  Fly   553 RMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFW 617
            ..:||...|:.......|.:  :|..|.|     |:|.:.|:....:|.:|. |.|:..|.:.||
Worm   205 TWKANSKLNQSEHFPALDSN--LLKIEKG-----YVNISHVEVPLGRNVHIG-QFPVKDTEETFW 261

  Fly   618 RMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTE------ESSLEFGDYHVRTISVE-CNEDYMVA 675
            :.::::....|          .|..|.  ||.|      |....:|...:....|| ..::....
Worm   262 KAVFDKRITSI----------DVLVGD--EPIEFFPKKAEDYKNYGQMWINNRKVEHVIDEVFRF 314

  Fly   676 SLEL--RNIKTDEIRNVSHWQFTSWPDYGVP-------SSAMAMLNFLQKVREKQAQLVQGLGDT 731
            |:|:  .......|.||:  .|.:|....||       ..|:.:..||.|.
Worm   315 SIEVLPHGCSNSIICNVT--VFGNWKVDSVPVKQAIAIKEALGLNYFLLKT-------------- 363

  Fly   732 WAGHPRGPPIVVHCSAGIGRTGTFITLDICI----SRLEDVGTADIRGTVEKIRSQRAYSIQMPD 792
                |.....::....|.||.|.|:.|.:.:    :::.:...|||   |:.||:||..::....
Worm   364 ----PADDNAMIISPHGAGRAGYFLALAVAVHTIDTKIAEPNIADI---VKSIRTQRPRAVDSFC 421

  Fly   793 QYVFCHLALIEY 804
            ||...:::|:.:
Worm   422 QYCSLYISLLYF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	57/265 (22%)
		PTPc	559..803	CDD:238006	56/263 (21%)
ptp-5.1	NP_500733.2	PTPc	185..432	CDD:214550	61/297 (21%)
ptp-5.1	NP_500733.2	PTPc_motif	334..432	CDD:214649	26/118 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910