DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and Y69A2AR.19

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_500211.3	Gene:	Y69A2AR.19 / 177036	WormBaseID:	WBGene00022090	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	159/743 - (21%)
Similarity:	266/743 - (35%)	Gaps:	191/743 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 SALQD---SETQRAGLVFIYDMSGS--KYSNF---------DYDLSQKILTLLKGGYPARLKKVL 263
            |.|||   :.|:...:|.....|||  |:..:         |.| ...:.|::.||..||:.|:.
Worm   583 SDLQDPTATATEVKAVVESIQKSGSLEKFKQYLLLLQKTFADVD-GNNLKTVILGGIKARITKIG 646

  Fly   264 IVTAPLWFKAPFKILRLFVREKLRERVFT--VSVPQLALHVPRKALPIHLGGTLEV------DHA 320
            ..|...:.|...|:......::.:.|..:  :...|....:..|.|. .:|.....      |.|
Worm   647 DSTFGDFIKEELKVHTCLKAQEEQSRKLSQAIQATQSLRKLDEKMLE-EVGSAASAVSSFAKDLA 710

  Fly   321 TWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATI--------- 376
            | :.|..::|......:..::.|:.....:..:.|.:  ||:....:|.....:.|
Worm   711 T-IKSIPETMKKEAKGVSTDLNGMADAKKNSDSVGQS--VSSLQDASELIELESAIKELKGFGPE 772

  Fly   377 ----ISAVH----------QLGDNNTTVVTVSNG------------VGPAGSASGGATTAASAAT 415
                |.||.          |.|::::.:.::.:|            |..|.:.|...|..|:...
Worm   773 IDGYIKAVKSPEDRKAIETQWGNHHSDMASLESGLKAAKGFVDKIDVSKAKTMSDYGTPLANLKD 837

  Fly   416 EPNENIT-----------INGLSPSHRQAANNSSSSSSSAA------TVANPLKL---------- 453
            .|:..|.           |..|.|..|:.|.:...:...||      ..|..|:.
Worm   838 LPDVKINALEKIKALDALIKALPPPKRKRATSDPKTVMEAAKSTLEKIAALDLQFSNHKTQYQQA 902

  Fly   454 --------------------NTSGSADNNSTITNATTAAGAAGAAAGTTTNGG---GEFWSENPP 495
                                |::|.:|:..:||......|:..|..|...  |   |..|.|...
Worm   903 PAAFKAFHDFLAKFLVTTHSNSTGGSDSGISITLIIIIVGSILALIGVAV--GIYFGVRWYEKKK 965

  Fly   496 SSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHA-------- 552
            ::....                 .:||..||.:....|  |.|.|...|.    ||.
Worm   966 AAEQME-----------------HEIVVWVKAQAYKSL--EAAIIVLVAS----LHVVWGTQTSV 1007

  Fly   553 ---RMRANLTKNRYTDVL---CYDHSRVVLAHEDGDEPSDYINANF------VDGYKQKNAYIST 605
               :..|.|.|.:....|   |...:.|.:..:....|   |:||:      |||..||  :|:|
Worm  1008 SVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDGTRIP---IHANWINTSPDVDGNTQK--FIAT 1067

  Fly   606 QGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNE 670
            |||||.||.|||.|:.......:||..:.:|:...||.:|:.......::...|.::|::   .|
Worm  1068 QGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVT---QE 1129

  Fly   671 DYMVASLELRNIKTDE------IRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLG 729
            ..:..|...|.|:.::      .|.::|:|:.||||.|:|.......:.:...:|.:
Worm  1130 QILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK-------- 1186

  Fly   730 DTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQY 794
                     .|||||||||||||.:||......|.:....|..:...|.::|.||..:||..:|.
Worm  1187 ---------KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQM 1242

  Fly   795 VFCHLALIEYAYSRGMLQTVDLAGFDER 822
            .:..:..:   |.....:.:|:..:.|:
Worm  1243 YWVQVGSV---YRLSKEKNIDMKHYKEQ 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099	26/116 (22%)
		Y_phosphatase	557..803	CDD:278528	73/260 (28%)
		PTPc	559..803	CDD:238006	72/258 (28%)
Y69A2AR.19	NP_500211.3	WSN	172..234	CDD:280385
		Y_phosphatase	1018..1245	CDD:278528	72/251 (29%)
		PTPc	1019..1245	CDD:238006	71/250 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910