Protein Alignment Ptpmeg2 and Ptpn21

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_598229.2
• Gene: Ptpn21 / 171070
• RGDID: 620216
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 177/789 - (22%)
• Similarity: 290/789 - (36%)
• Gaps: 203/789 - (25%)

  Fly    77 AVVPPQLQQLQVQ---LPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKF----DI 134
            ||..|:|..:|:|   .|||.                   :.|...:.....:.|.|..    |:
  Rat   536 AVSVPELTNVQLQAQDYPAPN-------------------IMRTQVYRPPPPYPYPRPANSTPDL 581

  Fly   135 PRAVSLYEQHEQIRLKEYLYNIDPDV--EPLRSELQTGKFTILPARTSSGAAIALFTANRHSPLS 197
            .|.:             |:.:.:||:  ..:...:||.:...||...|........||.||:.|.
  Rat   582 SRHL-------------YISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAHLQ 633

  Fly   198 VSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKV 262
            ..::..:.|:.:..:           ||
  Rat   634 KRNSIEIAGLTHGFE-----------GL------------------------------------- 650

  Fly   263 LIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCR 327
                                  :|:||..:.|...:|   ||         |......:.:.|.:
  Rat   651 ----------------------RLKERTMSASAADVA---PR---------TFSAGSQSSVFSDK 681

  Fly   328 QSMTNREDELLANIVGVGGGSGSGSAAGSAAIVST--------NGTETEAATTAATIISAVHQLG 384
            ......|::      |.||.|...|.:.:..::.:        :.:..|.|.:...:.:|..|..
  Rat   682 VKQEGTEEQ------GSGGYSHKKSLSDATMLIHSSEEDEDLEDDSSREHAVSEPRLTAAFSQEQ 740

  Fly   385 DNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSH---------RQAANNSSSS 440
            ..|....:|:...||.     ......|..|||.:.  ...:||.|         |......|.|
  Rat   741 QLNYPCASVTPVTGPL-----HIFEPKSHVTEPEKR--AKDISPVHLVMETHQPRRHGLLTPSMS 798

  Fly   441 SSSAATVANPLKLNTSGS-----------------ADNNSTITNATTAAGAAGAAAGTTTNGGGE 488
            .|.         |.|||.                 :...:|:.......|.....|.....|..:
  Rat   799 ESD---------LTTSGRYRARRDSLKKRPVSDLLSGKKNTVEGLPPLGGMKKTRADAKKIGPLK 854

  Fly   489 FWSENPPSSASSGFSDDDSLAGQEGDPKPI-DQIVQMVKQRGRHGLI-KEYADI-RNRAPEGTFL 550
            ..:.|..|.:.....|:    |:|...:.. |:..::::||...|.: .||..| :.|..:|...
  Rat   855 LAALNGLSLSRLPLPDE----GKEVSTRATNDERCKVLEQRLEQGTVFTEYERILKKRLVDGECS 915

  Fly   551 HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANF----VDGYKQKNAYISTQGPLPK 611
            .||:..|..:||:.|||.||.:||.|. ...:..:.||||:.    |.|.:..  ||:|||||..
  Rat   916 TARLPENAERNRFQDVLPYDDARVELV-PTKENNTGYINASHIKVSVSGIEWD--YIATQGPLQN 977

  Fly   612 TSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWE--PTEESSLEFGDYHVRTISVECNEDYMV 674
            |.||||:|:|||...:|.|.|...|.||.|..:||.  .:..:::.:|.:.:.|.....:..|..
  Rat   978 TCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYAT 1042

  Fly   675 ASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPR-- 737
            ..|:::::.|.:.|.|.|.|:|.||::|.|......|::|::::..:..      ......||
  Rat  1043 TGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRH------TNSTSEPRSP 1101

  Fly   738 GPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI 802
            .||::||||||:||||..|..:|.::.||.....||...:|.:|.||...:|...||.|.:..||
  Rat  1102 NPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLELLRQQRMMLVQTLSQYTFVYRVLI 1166

  Fly   803 EYAYSRGML 811
            ::..|..::
  Rat  1167 QFLKSSRLI 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/33 (15%)
		SEC14	170..314	CDD:469559	18/143 (13%)
		PTPc-N9	529..799	CDD:350391	94/279 (34%)
Ptpn21	NP_598229.2	FERM_F1_PTPN21	20..106	CDD:340712
		B41	24..222	CDD:214604
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..445
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..702		11/56 (20%)
		PTP_DSP_cys	884..1170	CDD:475123	98/294 (33%)