Protein Alignment Ptpmeg2 and IA-2

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_061516681.1
• Gene: IA-2 / 1277829
• VectorBaseID: AGAMI1_004623
• Length: 1037
• Species: Anopheles gambiae
• Alignment Length: 837
• Identity: 203/837 - (24%)
• Similarity: 321/837 - (38%)
• Gaps: 215/837 - (25%)

  Fly   130 RKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIALFTANRHS 194
            |:..:.||:...:||.. .:.:||     |:....:|::..:  :||.:.:.|.....:.||:..
Mosquito   217 RRIALGRAMKQQQQHPP-DVTDYL-----DMGAEVNEIEDSQ--LLPFKAAEGERDWAYGANKRG 273

  Fly   195 PLSV---------SHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGS-----------KYSNF 239
            ...:         .....|:.:|.:|..|..|.|.:     :||..:.|           |.|||
Mosquito   274 STGIFRDQQAGGNDEERALKDLVDRLTPADVDPEFE-----YIYPKTSSFREYAKEHHIPKISNF 333

  Fly   240 DYD----LSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREK------LRERVFTVS 294
            ..:    |.|:.....|...|         ....::..|.|.|....|.:      |||......
Mosquito   334 APENINRLQQEAAGAAKANDP---------NVDKFYTHPHKALAQHARNEIPAAGNLRESAAYAP 389

  Fly   295 VPQLA--------LHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNRE----------------- 334
            .|:..        ::||:.      ||:...|.|..||......|.||
Mosquito   390 GPEAGGMYTEGGFVYVPKS------GGSPGKDEARTLLDNILGFTRRERLDVKKPGPPAAPPPSS 448

  Fly   335 -------------------------------------DE-------------LLANIVGVGGGSG 349
                                                 |:             :|.|.:. ....|
Mosquito   449 QSPSEPPKETAPSQDKAHGEEGEKRPKSKKELFAHTDDDHAPHSVDTEYAHVILKNPID-NWKDG 512

  Fly   350 SGSAAGSAAIVSTNGTET-------------EAATTAATIISAVHQLGD----NNTT----VVTV 393
            |...|..|.:::..|..|             ||.....|......|:.|    ||.:    |:.:
Mosquito   513 SRIVAALAELLNMQGYFTHPRVDRHEVSFRVEANPDRKTAADVAKQINDSRFKNNLSRRLGVLVI 577

  Fly   394 SNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKL----- 453
            ..|||.. :.....::......|...|:|       |..|...:.:.:::...||..|.|
Mosquito   578 QAGVGDK-TKETDVSSQRLKRVEDGPNVT-------HVMAYMFAGAGAAAVIVVAMTLFLIRKHD 634

  Fly   454 ----------NTSGSADNNS----TITNATTAAGAAGAAAGTTTNGG-----GEFWSENPPSSAS 499
                      :..|..|::|    .:..|..|.|..| .||:.:.||     .:.....||||.|
Mosquito   635 KKKDKLGGLQSGLGGGDSSSKDYQDLCRARMAGGKTG-PAGSDSPGGRITALTKEAEARPPSSRS 698

  Fly   500 --SGFSDDDSLAGQE--GDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTK 560
              |.:|::.:|...:  .....:..:...::.:||  |.:|:..:.....|.:...|.::|....
Mosquito   699 STSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGR--LQREWEALCRYEAEPSARDAALQAQCAP 761

  Fly   561 -NRYTDVLCYDHSRVVLAHEDGDEPSDYINANFV-DGYKQKNAYISTQGPLPKTSQDFWRMIWEQ 623
             ||....|.||||||||.|....|..|||||:.: |...:..||::.|||:..|...||:|:|||
Mosquito   762 LNRPGAPLPYDHSRVVLNHLANAEGMDYINASTITDHDPRAPAYVAAQGPMQSTLAHFWQMVWEQ 826

  Fly   624 HCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTIS--VECNEDYMVASLELRNIKTDE 686
            ..:|:|...|:.|.|...|.:||  .||.:..:..|.|..:|  :.| :||:|.|..|:|::|.|
Mosquito   827 GAVVLVALCRLQENGESACARYW--PEEGAEVYHIYEVHLVSEHIWC-DDYLVRSFYLKNLRTGE 888

  Fly   687 IRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGR 751
            .|.|:.:.|.|||..|||:||.|:|:|.:||.:           ::.|  |..|||||.|.|.||
Mosquito   889 TRTVTQFHFLSWPQGGVPTSAKALLDFRRKVNK-----------SYRG--RSCPIVVHSSNGSGR 940

  Fly   752 TGTFITLDICISRL-EDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS 807
            ||.:|.||:.:.|: :.....||..|:|.:|.|||..:....|:.|..:|:.|..::
Mosquito   941 TGAYILLDLVLGRMNKGAREIDIAATLEHLRDQRAGLVATRQQFEFVLMAVAEEVHA 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	3/13 (23%)
		SEC14	170..314	CDD:469559	33/181 (18%)
		PTPc-N9	529..799	CDD:350391	103/274 (38%)
IA-2	XP_061516681.1	None