Protein Alignment Ptpmeg2 and Ptpn6

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_446360.2
• Gene: Ptpn6 / 116689
• RGDID: 620660
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 689
• Identity: 168/689 - (24%)
• Similarity: 263/689 - (38%)
• Gaps: 227/689 - (32%)

  Fly   158 PDVEP-LRSELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQ 221
            ||.|. |:.....|.|...|:|.:.|          ...|||           ::|..:.....|
  Rat    14 PDAETLLKGRGVPGSFLARPSRKNQG----------DFSLSV-----------RVDDQVTHIRIQ 57

  Fly   222 RAGLVFIYDM-SGSKYSNFD-----YDLSQKIL-----TLLKGGYPARLKKVLIVTAPLWFKAPF 275
            .:|  ..||: .|.|::...     |...|.||     |::...||.....   .|:..|:..
  Rat    58 NSG--DFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSD---PTSERWYHG-- 115

  Fly   276 KILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGG-----TLEVDHATWLLSCRQSMTNRED 335
                                              |:.|     .|:.....|....|:|::...|
  Rat   116 ----------------------------------HMSGGQAESLLQAKGEPWTFLVRESLSQPGD 146

  Fly   336 ELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPA 400
            .:|                                    ::::...:.|..:...||....:...
  Rat   147 FVL------------------------------------SVLNDQPKAGPGSPLRVTHIKVMCEG 175

  Fly   401 GSASGGATTAASAATEPNENITINGL-----------SPSHRQAANNSSSSSSSAATVAN-PLKL 453
            |..:.|.:....:.|:..|:....|:           .|.:....|        ||.:.| .|:|
  Rat   176 GRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVN--------AADIENRVLEL 232

  Fly   454 NTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPI 518
            |....:::       |..||               ||.|            .:||..||
  Rat   233 NKKQESED-------TAKAG---------------FWEE------------FESLQKQE------ 257

  Fly   519 DQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDE 583
               |:.:.||           :..:.||          |.:||||.::|.:|||||:|...|.:.
  Rat   258 ---VKNLHQR-----------LEGQRPE----------NKSKNRYKNILPFDHSRVILQGRDSNI 298

  Fly   584 P-SDYINANFVDGY-----KQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKC 642
            | |||||||:|...     :....||::||.|..|..|||:|.|:::..|||||||.:|:||.||
  Rat   299 PGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKC 363

  Fly   643 GQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKT-DEIRNVSHWQFTSWPDYGVPSS 706
            ..|| |...:...:|.|.|.........:|.:.:|::..:.. |.:|.:.|:|:.||||:||||.
  Rat   364 VPYW-PEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSE 427

  Fly   707 AMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGT- 770
            ...:|:||.::.::|..|           |...||:||||||||||||.|.:|:.   :|.|.|
  Rat   428 PGGVLSFLDQINQRQESL-----------PHAGPIIVHCSAGIGRTGTIIVIDML---MESVSTK 478

  Fly   771 -----ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804
                 .||:.|::.:|:||:..:|...||.|.::|:.::
  Rat   479 GLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559	26/159 (16%)
		PTPc-N9	529..799	CDD:350391	102/282 (36%)
Ptpn6	NP_446360.2	SH2_N-SH2_SHP_like	6..103	CDD:198203	26/111 (23%)
		SH2_C-SH2_SHP_like	111..217	CDD:198185	18/177 (10%)
		PTPc-N6	255..520	CDD:350454	108/308 (35%)