Protein Alignment Ptpmeg2 and Ptpru

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_017448609.1
• Gene: Ptpru / 116680
• RGDID: 620782
• Length: 1452
• Species: Rattus norvegicus
• Alignment Length: 1028
• Identity: 228/1028 - (22%)
• Similarity: 353/1028 - (34%)
• Gaps: 373/1028 - (36%)

  Fly    18 SGSRSEQDSGCHRRLFLCIAKAVKQFIDLCNNLGA---NCSTTTATSPSTSSSSASSTQNLIAVV 79
            |..|||||      |:.|:::|.:         ||   |.:......|.|            .:.
  Rat   253 SVGRSEQD------LYRCVSQAPR---------GAGVSNFAELIVKEPPT------------PIA 290

  Fly    80 PPQLQQ-----LQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVS 139
            ||||.:     |.:||     ...:..|.|        |:.|     ..:::..||.   |.|
  Rat   291 PPQLLRAGPTYLIIQL-----NTNSIIGDG--------PIVR-----KEIEYRMARG---PWA-- 332

  Fly   140 LYEQHEQIRLKEY-LYNIDPDVE--------------------PLRSELQTGKFTILPARTSSGA 183
              |.| .:.|:.| |:::|||.|                    ||.|..:..:    |.|...|.
  Rat   333 --EVH-AVNLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLLSRTKCAE----PTRAPKGL 390

  Fly   184 AIALFTAN----RHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLS 244
            |.|...|.    :..||..:.|.               ..|....|.:.|.:.||.....
  Rat   391 AFAEIQARQLTLQWEPLGYNVTR---------------CHTYAVSLCYHYTLGGSHNQTI----- 435

  Fly   245 QKILTLLKGGYPARLKKV---------LIVTAP-------------------------------- 268
            ::.:.:.:|.....:|.:         ||:|.|
  Rat   436 RECVKMERGASRYTIKNLLPFRNVHVRLILTNPEGRKEGKEVTFQTDEDVPGGIAAESLTFTPLE 500

  Fly   269 ----LWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKAL------PIHLGGTLEVDHATWL 323
                |.::.|.:...|..:.::..:....|.|.:.:..||:.:      ..|:...|: ...|:|
  Rat   501 DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLQ-PGTTYL 564

  Fly   324 LSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISA--------V 380
            .|.| :.|::               |.|.|               |.|...|.|||        .
  Rat   565 FSVR-ARTSK---------------GFGQA---------------ALTEITTNISAPSFDYADMP 598

  Fly   381 HQLGDNNTTVVTV---SNGVG---------------------PAGS-------------ASG--- 405
            ..||::..|:..:   :.|.|                     |.|.             |.|
  Rat   599 SPLGESENTITVLLRPAQGRGAPISVYQVVVEEERPRRLRREPGGQDCFSVPLTFETALARGLVH 663

  Fly   406 --GATTAASAATEP-----NENITING-----LSPS-----HRQAAN--------NSSSSSSSAA 445
              ||..|||:..|.     .:|.|..|     |.|.     :.|||:        |....:..||
  Rat   664 YFGAELAASSLLEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAA 728

  Fly   446 TVANPLKLNTSGSADNNSTITNATTAAGAA------GAAAGTTTNGGGEF---WSENPPSSA--- 498
            ...:...|..|..::....|. ...|.|.|      ||.......|...:   :...|.:.|
  Rat   729 CKESKRPLEVSQRSEEMGLIL-GICAGGLAVLILLLGAIIIIIRKGRDRYAYSYYPKPVNMAKAT 792

  Fly   499 -----------------------------------------------SSGFSDDDSL-------- 508
                                                           |||.::..||
  Rat   793 VNYRQEKTHMMTAVDRSFTDQSTLQEDERLGLSFMDAPGYSPRGDQRSSGVTEASSLLGGSPRRP 857

  Fly   509 AGQEGDPKPIDQI------------VQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKN 561
            .|::|.|....|:            :..:|....:|..:||....    || :...:.:..|...
  Rat   858 CGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFF----EG-WDATKKKDKLKSG 917

  Fly   562 RYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD------GYKQKNAYISTQGPLPKTSQDFWRMI 620
            |...|..||..||.|....||..:|||:||::|      ||.:.|.:|:||||.|:...|||||:
  Rat   918 RQEPVSAYDRHRVKLHPMLGDPDADYISANYIDIRINRQGYHRSNHFIATQGPKPEMIYDFWRMV 982

  Fly   621 WEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTD 685
            |::.|:.:||.::::|.|||||.:||  .|:|.: :||..:..:..|...:|:|.:..|......
  Rat   983 WQEQCVSVVMISKLVEVGRVKCSRYW--PEDSDM-YGDIKITLVKTETLAEYVVRTFALERRGYS 1044

  Fly   686 EIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIG 750
            ....|..:.||:||::|||..|..:|.|:::|:....             |...|:|:|||||.|
  Rat  1045 ARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-------------PDAGPVVIHCSAGTG 1096

  Fly   751 RTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            |||.:|.||:.:...|..|..||...|:.:.|:|...||..:||:|.|.|::|
  Rat  1097 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	6/29 (21%)
		SEC14	170..314	CDD:469559	28/198 (14%)
		PTPc-N9	529..799	CDD:350391	94/275 (34%)
Ptpru	XP_017448609.1	MAM	22..186	CDD:214533
		fn3	291..365	CDD:394996	24/99 (24%)
		FN3	<347..>624	CDD:442628	55/332 (17%)
		fn3	494..577	CDD:394996	15/99 (15%)
		PTP_DSP_cys	943..1153	CDD:475123	81/223 (36%)
		R-PTPc-U-2	1238..1444	CDD:350485