Protein Alignment Ptpmeg2 and PTPRT

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_573400.3
• Gene: PTPRT / 11122
• HGNCID: 9682
• Length: 1460
• Species: Homo sapiens
• Alignment Length: 930
• Identity: 239/930 - (25%)
• Similarity: 358/930 - (38%)
• Gaps: 279/930 - (30%)

  Fly    56 TTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGG----------- 109
            |||.|...|.... |....|..:.|....:::|.|..|      |.||.|..|.
Human   329 TTTGTWAETHIVD-SPNYKLWHLDPDVEYEIRVLLTRP------GEGGTGPPGPPLTTRTKCADP 386

  Fly   110 ------------------------GAAPVRRHISHTTAVKFLYA---RKFDIPRAVSLYEQHE-- 145
                                    |.|..|.| |:...|::.|.   ::::....:.....:.
Human   387 VHGPQNVEIVDIRARQLTLQWEPFGYAVTRCH-SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLR 450

  Fly   146 ------QIRLKEYLYNID----------------PDVEPLRSELQTGKF------TILPARTSSG 182
                  .|||:..|.|.:                |...||.| :|.|.|      ...|...::|
Human   451 GLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLES-IQGGPFEEKIYIQWKPPNETNG 514

  Fly   183 AAIALFTANRHSPLSVSHTTTL---QGIVYQLDSALQDSETQR------AGLVFIYDMSGSKYSN 238
             .|.|:..|..:..|:..:..|   :|.|::|     .:||..      .|..:.:.:..|....
Human   515 -VITLYEINYKAVGSLDPSADLSSQRGKVFKL-----RNETHHLFVGLYPGTTYSFTIKASTAKG 573

  Fly   239 FDYDLSQKILTLLKGGYPARLK------------KVLIVTAPLWFK-APFKILRLFVREKLRER- 289
            |...::.:|.|.:..  |:..:            .:.::..|...: ||..:.:|.|:|:..::
Human   574 FGPPVTTRIATKISA--PSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKS 636

  Fly   290 --------VFTV-----------SVPQLALHVPRKALPIHLGGTLEVDHATW----------LLS 325
                    .|:|           |:...|..:....||:....|:. |:.|:          |.|
Human   637 RRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVG-DNKTYNGYWNPPLSPLKS 700

  Fly   326 CR---QSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNN 387
            ..   |:::....|...|.|.:...:..|||.      .|.||.....||.|:.        .|:
Human   701 YSIYFQALSKANGETKINCVRLATKAPMGSAQ------VTPGTPLCLLTTGAST--------QNS 751

  Fly   388 TTV---VTVSNGVGPAGSASG---------GATTAASAATEPNENITI----NGLSPS-HRQAAN 435
            .||   ..|.|.|..||..:|         |..            :||    |..|.| :.:.|.
Human   752 NTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVM------------LTIKRRRNAYSYSYYLKLAK 804

  Fly   436 NSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASS 500
            ....:.|.|.....|:     .|||..:|..:|                      |.|....:||
Human   805 KQKETQSGAQREMGPV-----ASADKPTTKLSA----------------------SRNDEGFSSS 842

  Fly   501 -----GFSDDDSLAGQEG-----------------DP----KPIDQ-------------IVQMVK 526
                 ||:|     |..|                 ||    .|.||             |.||.:
Human   843 SQDVNGFTD-----GSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKR 902

  Fly   527 QRGRHGLIKEYADIRNRAPEG---TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYI 588
            .:| :|..:||..:    |||   ::..|:...|..||||.:::.||||||.|...|||..||||
Human   903 GQG-YGFKEEYEAL----PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYI 962

  Fly   589 NANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESS 653
            |||::|||.:...||:||||:.:|.:|||||||:::...|||.|.::|.|||||.:||....|
Human   963 NANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTE-- 1025

  Fly   654 LEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVR 718
             .:||..|..|..|...:|::.:..::.....|||.:..:.||||||:|||..|..:|.|:::|:
Human  1026 -VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK 1089

  Fly   719 EKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQ 783
                         :...|...|||||||||.||||.||.:|..:...|:.|..||...|.::|:|
Human  1090 -------------FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQ 1141

  Fly   784 RAYSIQMPDQYVFCHLALIE 803
            |...:|..:||||.|.|::|
Human  1142 RVNLVQTEEQYVFVHDAILE 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/32 (16%)
		SEC14	170..314	CDD:469559	32/191 (17%)
		PTPc-N9	529..799	CDD:350391	112/272 (41%)
PTPRT	NP_573400.3	MAM	29..189	CDD:214533
		fn3	294..360	CDD:394996	8/31 (26%)
		FN3	390..480	CDD:238020	12/90 (13%)
		fn3	502..577	CDD:394996	15/80 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858		17/80 (21%)
		R-PTPc-T-1	929..1165	CDD:350478	107/249 (43%)
		R-PTPc-T-2	1250..1455	CDD:350482