Protein Alignment Ptpmeg2 and PTPN21

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_008970.2
• Gene: PTPN21 / 11099
• HGNCID: 9651
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 930
• Identity: 215/930 - (23%)
• Similarity: 343/930 - (36%)
• Gaps: 203/930 - (21%)

  Fly    34 LCIAKAVKQFIDLCNNLGANCSTTTAT-SP----STSSSSASSTQNLIAVVPPQLQ--------- 84
            ||:|:.....::.|     |..|.|.| :|    |:|..|....|..:...||||.
Human   296 LCVARHKFYRLNQC-----NLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPY 355

  Fly    85 -QLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIP---RAVSLYEQHE 145
             ..|..|..|...|                   :..|:..  .|...:.|:.   |..|:|..|.
Human   356 ASSQDNLFVPNQNG-------------------YYCHSQT--SLDRAQIDLNGRIRNGSVYSAHS 399

  Fly   146 QIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIA-LFTANRHS---PLSVSHTTTLQG 206
                ...|.|..|.::|  |.:.:.     |:.|.|..... ...::|||   |.|...|...:.
Human   400 ----TNSLNNPQPYLQP--SPMSSN-----PSITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYET 453

  Fly   207 IVYQLDSALQDSETQRAGLVFIYDMSGSKYS------------------------NFDYDLSQKI 247
            ::.||:..|..:|.|...|..:...|...||                        :..:.||...
Human   454 VMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSF 518

  Fly   248 LTLLKGGYPARLKKVL-IVTAPLWFKAPFKILRLFVREKLRERVF-----------TVSVPQLAL 300
            .:.....|||..:.|: .|:.|....|..:.........:|.:|:           ..|.|.|:.
Human   519 HSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSR 583

  Fly   301 H----------VPRKALPIHLG------GTLEVDHATW-----LLSCRQSMTNREDELLANIVGV 344
            |          :.|:   :|..      .:|.|.|:..     |.:.|.:..::.:.:  .:.|:
Human   584 HLYISSSNPDLITRR---VHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSI--EVAGL 643

  Fly   345 GGG---------SGSGSAA---------GSAAIVSTNGTETEAATTAATI-ISAVHQLGDNNTTV 390
            ..|         :.|.|||         ||...|.|..|:.|....|..: ......|.|....:
Human   644 SHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLI 708

  Fly   391 VTVSNGVGPAGSASGGATTAASAATEPNENIT--------------INGLSP-SHRQAANNSSSS 440
            .:.............||....:.|.||...:.              ::.|.| :|...|......
Human   709 HSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMD 773

  Fly   441 SSSAATVANPLK---------------LNTSG----SADNNSTITNATTAAGAAGAAAGTTTNGG 486
            ||...|.|...:               |.|||    ..|:......:...:|......|....||
Human   774 SSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGG 838

  Fly   487 GEFWSENPPS------SASSGFSDDDSLAGQEGDPKPI------DQIVQMVKQRGRHGLI-KEYA 538
            .:....:...      :|.:|.|........||  |.:      |:..::::||...|:: .||.
Human   839 MKKTRVDAKKIGPLKLAALNGLSLSRVPLPDEG--KEVATRATNDERCKILEQRLEQGMVFTEYE 901

  Fly   539 DI-RNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANF----VDGYKQ 598
            .| :.|..:|....||:..|..:||:.|||.||..||.|. ...:..:.||||:.    |.|.:.
Human   902 RILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELV-PTKENNTGYINASHIKVSVSGIEW 965

  Fly   599 KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWE--PTEESSLEFGDYHV 661
            .  ||:|||||..|.||||:|:|||...:|.|.|...|.||.|..:||.  .:..:::.:|.:.:
Human   966 D--YIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKI 1028

  Fly   662 RTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQ 726
            .|.....:..|....|:::::.|.:.|.|.|.|:|.||::|.|......|::|::::..:    :
Human  1029 TTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVR----R 1089

  Fly   727 GLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMP 791
            ....|.......||::||||||:||||..|..:|.|:.||.....||...::.:|.||...:|..
Human  1090 HTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTL 1154

  Fly   792 DQYVFCHLALIEYAYSRGML 811
            .||.|.:..||::..|..::
Human  1155 CQYTFVYRVLIQFLKSSRLI 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	6/32 (19%)
		SEC14	170..314	CDD:469559	35/199 (18%)
		PTPc-N9	529..799	CDD:350391	93/277 (34%)
PTPN21	NP_008970.2	FERM_F1_PTPN21	20..106	CDD:340712
		B41	24..222	CDD:214604
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	3/10 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..445		13/59 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..692		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..745		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	769..806		7/36 (19%)
		PTP_DSP_cys	883..1169	CDD:475123	97/292 (33%)