Protein Alignment Ptpmeg2 and PTPRU

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_005695.3
• Gene: PTPRU / 10076
• HGNCID: 9683
• Length: 1446
• Species: Homo sapiens
• Alignment Length: 1033
• Identity: 232/1033 - (22%)
• Similarity: 362/1033 - (35%)
• Gaps: 393/1033 - (38%)

  Fly    20 SRSEQDSGCHRRLFLCIAKAVKQFIDLCNNLGA---NCSTTTATSPSTSSSSASSTQNLIAVVPP 81
            ||:|||      |:.|:::|.:         ||   |.:......|.|            .:.||
Human   255 SRAEQD------LYRCVSQAPR---------GAGVSNFAELIVKEPPT------------PIAPP 292

  Fly    82 QLQQ-----LQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLY 141
            ||.:     |.:||     ...:..|.|        |:.|     ..:::..||.   |.|
Human   293 QLLRAGPTYLIIQL-----NTNSIIGDG--------PIVR-----KEIEYRMARG---PWA---- 332

  Fly   142 EQHEQIRLKEY-LYNIDPDVE--------------------PLRSELQTGKFTILPARTSSGAAI 185
            |.| .:.|:.| |:::|||.|                    ||.|..:..:    |.|...|.|.
Human   333 EVH-AVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAE----PMRAPKGLAF 392

  Fly   186 ALFTANR------------------------HSPLSVSHTTTL-------QG------------- 206
            |...|.:                        |..|..||..|:       ||
Human   393 AEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457

  Fly   207 -------------------IVYQLD--------------SALQD------SETQRA-GLVFIYDM 231
                               :.:|.|              :.|:|      .|.|.. ||:..|::
Human   458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEI 522

  Fly   232 S------------------------------------GSKY------------------------ 236
            |                                    |:.|
Human   523 SYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNI 587

  Fly   237 --SNFDY-DL------SQKILTLL----KG-GYPARLKKVLI-----------------VTAPLW 270
              .:||| |:      |:..:|:|    :| |.|..:.:|::                 ...||.
Human   588 SAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLT 652

  Fly   271 FKAPFK--ILRLFVRE----KLRERV-FTVS---------VPQLALHVPRKALPIHLGGTLEVDH 319
            |:|...  ::..|..|    .|.|.: |||.         .|.|.   ||||..|:......:..
Human   653 FEAALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLE---PRKAYLIYFQAASHLKG 714

  Fly   320 ATWL--------LSCRQS-----MTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAAT 371
            .|.|        .:|::|     ::.|.:| :..|:|:       .|.|.|.::...|
Human   715 ETRLNCIRIARKAACKESKRPLEVSQRSEE-MGLILGI-------CAGGLAVLILLLG------- 764

  Fly   372 TAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANN 436
               .||..:.:..|:                      .|.|...:|   :.:...:.::||...:
Human   765 ---AIIVIIRKGRDH----------------------YAYSYYPKP---VNMTKATVNYRQEKTH 801

  Fly   437 SSS----SSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSS 497
            ..|    |.:..:|:....:|..| ..|.:...|.....:|  |....::..||    |...|
Human   802 MMSAVDRSFTDQSTLQEDERLGLS-FMDTHGYSTRGDQRSG--GVTEASSLLGG----SPRRP-- 857

  Fly   498 ASSGFSDDDSLAGQEGDPKPIDQI------------VQMVKQRGRHGLIKEYADIRNRAPEGTFL 550
                       .|::|.|....|:            :..:|....:|..:||....    || :.
Human   858 -----------CGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFF----EG-WD 906

  Fly   551 HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQD 615
            ..:.:..:..:|...:..||..||.|....||..:||||||::|||.:.|.:|:||||.|:...|
Human   907 ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 971

  Fly   616 FWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELR 680
            ||||:|::||..|||.|:::|.|||||.:||   .|.|..:||..:..:..|...:|:|.:..|.
Human   972 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYW---PEDSDTYGDIKIMLVKTETLAEYVVRTFALE 1033

  Fly   681 NIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHC 745
            .........|..:.||:||::|||..|..:|.|:::|:....             |...|||:||
Human  1034 RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-------------PDAGPIVIHC 1085

  Fly   746 SAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            |||.||||.:|.||:.:...|..|..||...|:.:.|:|...||..:||:|.|.|::|
Human  1086 SAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	6/29 (21%)
		SEC14	170..314	CDD:469559	54/334 (16%)
		PTPc-N9	529..799	CDD:350391	97/269 (36%)
PTPRU	NP_005695.3	MAM	22..186	CDD:214533
		fn3	291..365	CDD:394996	24/99 (24%)
		FN3	<347..>624	CDD:442628	42/280 (15%)
		fn3	494..577	CDD:394996	10/82 (12%)
		Mediates interaction with CTNNB1. /evidence=ECO:0000250	771..887		23/160 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..861		8/46 (17%)
		R-PTPc-U-1	943..1147	CDD:350480	86/217 (40%)
		R-PTPc-U-2	1232..1438	CDD:350485