DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg2 and ptpn9l

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	XP_002935509.1	Gene:	ptpn9l / 100489200	XenbaseID:	XB-GENE-5815286	Length:	694	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	321/717 - (44%)
Similarity:	437/717 - (60%)	Gaps:	69/717 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIA 186
            ||:|||.|||||:.||:.|::.:...||||.:|||:||.||||:||.:||||:||.|.::|||:|
Frog    36 TALKFLMARKFDVTRAIDLFQAYRNTRLKEGIYNINPDEEPLRAELLSGKFTVLPGRDANGAALA 100

  Fly   187 LFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLL 251
            ||||..|.|...:|...||.|:||||.|::..||||.||:|||||..|.|.||||:|..|||.||
Frog   101 LFTARLHRPDVTTHKAVLQAIIYQLDKAIERVETQRNGLIFIYDMINSTYGNFDYELCVKILNLL 165

  Fly   252 KGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLE 316
            ||.:|||||.|.||::||||:|||.:|||||||||||||.||...:|..|:|:::||.|||||.:
Frog   166 KGAFPARLKCVFIVSSPLWFRAPFAVLRLFVREKLRERVRTVKAHELVNHIPKESLPDHLGGTSK 230

  Fly   317 VDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVH 381
            :.|..|:.||..|...:|:....:.:.:...|.....:..   :::|.|:.........|.:..|
Frog   231 ISHVAWIQSCVNSRQTQENGDCMDHLFMIYASDQNPVSDR---LNSNCTQQNVTDNTRLINNHYH 292

  Fly   382 QLGDNN-TTVVTVSNGVGPAGSASGG--------ATTAASAATEPNENITINGLSPSHRQAANNS 437
            :....| :.|..||:.|...|||..|        ::|..:....|.::.|... :|.::|.|:|.
Frog   293 ENRTKNYSDVHRVSSCVHWNGSAGSGNYDCYDKNSSTNTNCRRPPPQSETPPD-TPLYKQPADNP 356

  Fly   438 S--SSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASS 500
            |  .....:..:...::|:.....|...|:..
Frog   357 SIPPLPQKSRPLPTGMELSIHMPEDGGMTVLG--------------------------------- 388

  Fly   501 GFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTD 565
                                :||.||:..:.|:.:||.:||...|.|:|..::...|..||||:|
Frog   389 --------------------LVQHVKRMKKRGIFQEYEEIRKDPPVGSFDISKKSHNQAKNRYSD 433

  Fly   566 VLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVM 630
            |||.|.|||.|.....||.:|||||:|:|.||:|||||:||||||||..|||||:|||..|:|||
Frog   434 VLCLDLSRVKLGLVGTDETTDYINASFMDDYKRKNAYIATQGPLPKTFDDFWRMVWEQRVLIIVM 498

  Fly   631 TTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQF 695
            ||||:||||:||||||........:.|.:.:|.|.::..:|:.:..||:.|.:|||.|:|:|:|:
Frog   499 TTRVIERGRIKCGQYWPLEAGRGEDTGHFIIRNIHIDLFQDFKLTHLEVYNKQTDESRSVAHYQY 563

  Fly   696 TSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDI 760
            .||||:|||.||.|||:|..:|::.||..||.||..|.|||.||||||||||||||||||.||||
Frog   564 MSWPDFGVPKSASAMLDFRSQVKQHQAVAVQALGLEWTGHPAGPPIVVHCSAGIGRTGTFCTLDI 628

  Fly   761 CISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPD 825
            |:|||||:||.|:..||:::|:|||:|||..|||.||::|:||||..:|::..|:.:..| .|.|
Frog   629 CLSRLEDIGTVDVLQTVKRMRTQRAFSIQTWDQYYFCYMAIIEYAQRKGIIAPVEWSDTD-FETD 692

  Fly   826 SE 827
            ||
Frog   693 SE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	13/21 (62%)
		SEC14	170..314	CDD:238099	89/143 (62%)
		Y_phosphatase	557..803	CDD:278528	148/245 (60%)
		PTPc	559..803	CDD:238006	147/243 (60%)
ptpn9l	XP_002935509.1	CRAL_TRIO_N	11..58	CDD:215024	13/21 (62%)
		SEC14	80..230	CDD:214706	93/149 (62%)
		PTPc-N9	397..667	CDD:350391	155/269 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I1235
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H114222
Inparanoid	1	1.050	618	1.000	Inparanoid score	I873
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D515051at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm49360
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3336
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160