Protein Alignment Ptpmeg2 and ptpn14

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_031758936.1
• Gene: ptpn14 / 100379917
• XenbaseID: XB-GENE-985641
• Length: 1176
• Species: Xenopus tropicalis
• Alignment Length: 769
• Identity: 187/769 - (24%)
• Similarity: 286/769 - (37%)
• Gaps: 196/769 - (25%)

  Fly   118 ISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSG 182
            ||||.:...|....   |:||    |...:.||.:|....|...|.|....|........:..||
 Frog   529 ISHTVSTPELANVP---PQAV----QSAALMLKNFLSRPPPPYPPTRPASSTPDLASHRQKRVSG 586

  Fly   183 AAIALFTANRHSPLSVSHTTTLQGIVYQLDSA------LQDSETQRAGLVFIYDMSGSKYSNFDY 241
            ::..|.|  |....||.        .:|.|||      ||  |.....::.....|.:|..:|:
 Frog   587 SSPDLVT--RKVQQSVK--------TFQEDSAPVVHQSLQ--EVSEPLMMVKPHPSVNKCHSFE- 638

  Fly   242 DLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKA 306
                 ::|.:..|..|...|.:....|.             |..|||:|.|....|.|..|.:..
 Frog   639 -----VITNMVRGMEAMALKTMNAHLPR-------------RNTLREQVPTEESMQKAHEVQQLP 685

  Fly   307 LPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAAT 371
            :..|   ...:..||.|                                   |:|:...|.|
 Frog   686 MYHH---KKNISDATML-----------------------------------ILSSESEEEE--- 709

  Fly   372 TAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANN 436
                         :.:.:|...|...|.|.||...|..|......|.|       .|..|::.:|
 Frog   710 -------------EPHKSVSPTSPLQGMAYSAQLQAALARIPKKPPPE-------YPGPRKSISN 754

  Fly   437 SS---SSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGG----------E 488
            .:   .||:.::.:|   :..........:...:.|..|...|::.|.:.:...          |
 Frog   755 GALRHESSNISSVIA---RAKAMSQRPCQAACISKTEPAAMNGSSLGPSISEPDLTCVKERIKKE 816

  Fly   489 FWSENPPSSASSGFSDDD---------------SLAGQEGDPKPI-------------------- 518
            ...|.|   .|..||.:|               .:|..|...:|:
 Frog   817 PVKERP---VSEMFSIEDVIVEREIMMRNLEKQEMAALEAQKRPLMMAALNGLSVSRIARPEDRQ 878

  Fly   519 --------DQIVQMVKQRGRHGLI-KEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRV 574
                    |:..:.::.|...|:: .||..|..|.|||.|..|.:..||.:||..:.:.|:.:||
 Frog   879 DDTALIQMDERCKTLRWRLEEGMVFTEYEQIPKRKPEGVFTTAVLPENLERNRICEDIPYEENRV 943

  Fly   575 VLAHEDGDEPSDYINANFV-------DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTT 632
            .|. ...:.|:.||||:.:       |.:     ||:||||||.|..|||:|:|||...||.|..
 Frog   944 ELV-PTKENPTGYINASHIKVTVSGKDWH-----YIATQGPLPHTFHDFWQMVWEQGVNVIAMVN 1002

  Fly   633 RVMERGRVKCGQYWEP--TEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQF 695
            ...|.||.|..:||..  |:.:|..:|.:.|.|.....:..|....|:::::.|.:.|.|.|.||
 Frog  1003 ADEEEGRAKSHRYWPKLGTKHNSETYGKFKVTTNFRTDSGCYATTGLKVKHLLTGQERTVWHLQF 1067

  Fly   696 TSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPR---GPPIVVHCSAGIGRTGTFIT 757
            |.|||:|.|......|::|:::|..:..          .:|.   .||:|||||||:||||..:.
 Frog  1068 TDWPDHGCPDEMQGFLSYLEEIRSVRRH----------ANPSSLCNPPVVVHCSAGVGRTGVVVL 1122

  Fly   758 LDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGML 811
            .::.|..||:....:|...:..:|.||.:.||...||.|.:..||.:..|..::
 Frog  1123 TELMIRCLENNENIEIPAMLRHLREQRMFMIQTIAQYTFVYQVLIYFLKSSRLI 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	8/25 (32%)
		SEC14	170..314	CDD:469559	32/149 (21%)
		PTPc-N9	529..799	CDD:350391	97/282 (34%)
ptpn14	XP_031758936.1	FERM_F1_PTPN14_like	18..102	CDD:340619
		B41	22..220	CDD:214604
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009
		PTPc-N14	889..1171	CDD:350447	100/297 (34%)