Protein Alignment Ptpmeg2 and ptprz1

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001362251.1
• Gene: ptprz1 / 100125091
• XenbaseID: XB-GENE-1011831
• Length: 2281
• Species: Xenopus tropicalis
• Alignment Length: 698
• Identity: 195/698 - (27%)
• Similarity: 290/698 - (41%)
• Gaps: 164/698 - (23%)

  Fly   159 DVEP-LRSELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSAL------- 215
            |:.| :.|:.:.|     |:....|..||       |..|.|||.| ||.|...:|:.
 Frog  1381 DILPTVSSDAKMG-----PSVVDDGFIIA-------STYSTSHTET-QGNVVADNSSFVHREMLK 1432

  Fly   216 -----QDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPF 275
                 :.||....|..|   .:.:..:|.|.|:..              :..|..|.|:
 Frog  1433 NKTFSEHSEQSEDGSAF---STAAADNNIDSDMEG--------------ESYLSTTMPM------ 1474

  Fly   276 KILRLFVREKLRERVFTVSVPQLALHVPRKALPIH---LGGTLE--VDHATWLLSCRQSMTNRED 335
                             .|..|  .|:|..|...|   |...||  .:..:|.:     :|:.|
 Frog  1475 -----------------SSTGQ--KHIPFTAPETHIQTLNTLLENTSESRSWAV-----LTDEE- 1514

  Fly   336 ELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPA 400
                        ||||.:...:  :|.|.|.|:...:         .:.|.:.. ..|:...|.|
 Frog  1515 ------------SGSGPSTSDS--LSDNETSTDFNFS---------DINDRDKD-YEVAIQPGKA 1555

  Fly   401 GSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTI 465
            ....|...|:..:.|.....:    ::.|.....|..:|:||..:.|.     ...|......|:
 Frog  1556 DLTPGSEMTSPPSVTSERSPV----VNVSEADVVNQEASNSSHESRVG-----LAEGLESEEKTV 1611

  Fly   466 TNATTAAGAAGAAAGTTTNGGGEFW-----------SENPPSSASSG-------FSDDDSLAGQE 512
            ......:....... ....|...:|           .:|..|...|.       .:||......:
 Frog  1612 IPLVVVSSLTFICL-VVLVGILIYWRKCFQTAHFYLEDNASSRVISSPPIPVFPVADDVEAIPLK 1675

  Fly   513 GDPKPIDQIVQMVKQRGRHGLIKEYADIRN-RAPEG-TFLHARMRANLTKNRYTDVLCYDHSRVV 575
            ..||.::::      ..|:|...|:.:|:| .|..| |..::....|..||||.:::.||||||.
 Frog  1676 QFPKHVEEL------HSRNGFTDEFEEIQNCTADLGITSDNSNHPDNKNKNRYVNIVAYDHSRVK 1734

  Fly   576 LAH--EDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERG 638
            |:.  |...:.:|||||||||||.::.|||:.||||..|::|||||:||.:..||||.|.::|:|
 Frog  1735 LSQLGEKEGKATDYINANFVDGYNKQKAYIAAQGPLKSTAEDFWRMLWEHNVEVIVMITNLVEKG 1799

  Fly   639 RVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDE--------IRNVSHWQF 695
            |.||.||| |::.|. |:|.:.|...:.:....|.|.:..|||.|..:        .|.|..:.:
 Frog  1800 RRKCDQYW-PSDGSE-EYGSFLVTHKNTKVLAYYTVRTFILRNNKIKKGSQKGRHNERTVVQYHY 1862

  Fly   696 TSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDI 760
            |.|||.|||...:.:|.|   ||:..|....|.|          |:|||||||:|||||:|.||.
 Frog  1863 TQWPDMGVPEYTLPVLTF---VRKASATKCNGNG----------PVVVHCSAGVGRTGTYIVLDS 1914

  Fly   761 CISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR 808
            .:.:::..||.:|.|.::.|||||.|.:|..:||:|.|.||:|...||
 Frog  1915 MLKQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHDALVEAILSR 1962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559	32/158 (20%)
		PTPc-N9	529..799	CDD:350391	117/281 (42%)
ptprz1	NP_001362251.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:394996
		PTP_DSP_cys	1690..1960	CDD:475123	119/284 (42%)
		R-PTP-Z-2	2043..2246	CDD:350507