DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Magi3

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001152826.1	Gene:	Magi3 / 99470	MGIID:	1923484	Length:	1476	Species:	Mus musculus

Alignment Length:	1390	Identity:	236/1390 - (16%)
Similarity:	379/1390 - (27%)	Gaps:	585/1390 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPPAAPVPLQPLAASSACLADRSPVDPIAV-----------RLQQEEQAEGDDEEEEEEEEDDDD 55
            :|||.|.|.||           .|||.:..           |.....:.|..|....|||||:|.
Mouse   194 KPPAEPSPFQP-----------DPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDK 247

  Fly    56 DPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQL 120
                     ||.||:.|.|           |.::|...|:......|  |.||..:.::.:...:
Mouse   248 ---------EAVNGSGSME-----------TREMHSETSDCWMKTVP--SYNQTNSSMDFRNYMM 290

  Fly   121 ---GACALPQPSEASLT----------GSKETR--EPRHHQTLLSTKSCETPANNATLSPTNSYN 170
               ....||:..|.:.|          .:|.|.  :||..:...:.:.||
Mouse   291 RDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCE--------------- 340

  Fly   171 GSIGSDGGSSVGGGARRKSWTL--SPQSGG------------STPLSGAKKKTKTGAPTTTLSNA 221
                 ||....|       |..  .||.|.            ..|:..||:|.:.|  ...:.:|
Mouse   341 -----DGELPYG-------WEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLG--QAEIHSA 391

  Fly   222 NGDGFNLWVARECFETVPAEMVDTLSMAEVDEE--------VDEEEDEEAAAVESLLGAAAALQ- 277
            ..|     |.|..|...|:::...|..|.:.:.        :..:..:|...|:::|....|.|
Mouse   392 KTD-----VERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQD 451

  Fly   278 ------------------ASAH---VQRRQQQQHHQHLRQPSPPQHRPLERSWP----------- 310
                              ...|   ||..|....:|::       :..|.|.:|
Mouse   452 GKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYV-------NLTLCRGYPLPDDSEDPVVD 509

  Fly   311 -----PRAVG------------RDLKL----------QGDVFQFDILDTDERLAEEMAQGSGSSN 348
                 |...|            :|.||          .|.:...|.|:.....:|:.|..:.|.:
Mouse   510 IVAATPVINGQSLTKGETCMNTQDFKLGAMVLDQNGKSGQILASDRLNGPSESSEQRASLASSGS 574

  Fly   349 NSP-----------------LATPPVRFK------------------------------------ 360
            :.|                 :|..|...|
Mouse   575 SQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVV 639

  Fly   361 ------------PLLKKKIGPDSYINTISTQ-------------KVPVHQSYEFPTFPSSSAVGS 400
                        |||..:.||.|...|..|:             ..|:.|...||  ||....||
Mouse   640 EVLKQFPVGADVPLLILRGGPCSPTKTAKTKTDTKENSGSLETINEPIPQPMPFP--PSIIRSGS 702

  Fly   401 SSSSPNSLQFP-----------------YLRQHR-----------------------PLTRALSN 425
            ....|:.:...                 :||:..                       ||..|..:
Mouse   703 PKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKD 767

  Fly   426 GKASSSEE------------------------QASPRLLLSPKR--------------------- 445
            |:..:::|                        ..:..:||:.:|
Mouse   768 GRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESHQAFSQNG 832

  Fly   446 -PRSPPSGCSTRSA--SPLDISLSPEQHSPTRGRGVGGAL---QDAVPPGTPTFHGQRPQQRLLK 504
             ||...:...||||  ...|::|..:::     .|.|..:   :...|||.      .|.:  :.
Mouse   833 SPRLNRAELPTRSAPQEAYDVTLQRKEN-----EGFGFVILTSKSKPPPGV------IPHK--IG 884

  Fly   505 RVGGGAGAGATGG---------ATGSPLV-----------------------------CPPTPTH 531
            ||..|:.|...||         ..|..:|                             .||:.|:
Mouse   885 RVIDGSPADRCGGLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTN 949

  Fly   532 HARRHARLQAVTANSSLASGGAIPSDPPAVSSQL-------------DYIYLQD----------- 572
            .||:...||......  |....||.|..|:..::             |:.:|..
Mouse   950 SARQSPALQHRPMGQ--AQANHIPGDRIALEGEIGRDVCSSYRHSWSDHKHLAQPDTAVISVVGS 1012

  Fly   573 -------------------------GGQ------------EQGQEQSDEVVHISS--TRLPSIPE 598
                                     ||:            |.|....|..:|:..  ..:...|.
Mouse  1013 RHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1077

  Fly   599 RSAAAAAAAAAAAAGA----ALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTT 659
            :......|.....||.    .|:.||||.:            |....|:....|...:.|.
Mouse  1078 QGITHTRAIELIQAGGNKVLLLLRPGTGLI------------PDHGDWDTNSPSSSNVIYD---- 1126

  Fly   660 RTTSWQRPGAAPSGGPAGR-EQHH---------RQQLDRRYQSIRRTITNESRAAQLYNLPTSAN 714
                 ::|...||...|.. |:.|         |.|:..:.:.::.|: .|.::....:.|....
Mouse  1127 -----EQPPPLPSSHSASTFEESHVPATEDSLTRVQICEKAEELKDTV-QEKKSTLNGSQPEMKY 1185

  Fly   715 SNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMR---------- 769
            .:.:.|.....||..:.|.....|          ..|..:....|:|:.|..|.|
Mouse  1186 QSVHKTMSKKDPPRGSGHGEKSRL----------KGENGVTRRGRSASPKKSVNRHSEEHLEKIP 1240

  Fly   770 --IRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLP 832
              ::.||                   .:.||: .|....|.:..|:...     :..|..||.
Mouse  1241 RPLKSDP-------------------KEKSRD-RSLSPRKGESKGRLTI-----KAGSGQDPN-- 1278

  Fly   833 VECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVP-----PLPPPRPS 892
                |..|.|....::|..:|        ||.||.|.|.::.:.:...:|.|     .||..|..
Mouse  1279 ----RKDRGRSSSPKKQQKIG--------GNSLSNTEGKLSEAGSRRAAGHPRDSTEQLPDGREK 1331

  Fly   893 SSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQ 957
            |..|.............|.|....:...|.::..:...:|.....       ::..||.    ::
Mouse  1332 SGVSRKDLKQSQPGKTRTKSPEKKSSKVDETSLPSKKTSSTAGRV-------VSEKEKG----KK 1385

  Fly   958 PNILEILRERQGQHTM--SRQLREK 980
            |...|..||.. :||.  ::||:::
Mouse  1386 PTAGETSRETV-EHTQISAKQLKQE 1409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	3/28 (11%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
Magi3	NP_001152826.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:15652357	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:302627	3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		27/102 (26%)
		WW	297..329	CDD:197736	7/31 (23%)
		WW	345..375	CDD:238122	6/36 (17%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		12/88 (14%)
		PDZ	416..496	CDD:214570	11/86 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..575		5/23 (22%)
		PDZ	578..659	CDD:214570	6/80 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..691		4/26 (15%)
		PDZ	729..812	CDD:214570	9/82 (11%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		9/81 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		2/25 (8%)
		PDZ_signaling	851..936	CDD:238492	16/97 (16%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		16/99 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..966		7/28 (25%)
		PDZ_signaling	1023..1101	CDD:238492	11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1151		9/50 (18%)
		MIP-T3	<1166..>1431	CDD:287245	56/306 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1476		56/304 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900