DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Wwtr1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001161753.1	Gene:	Wwtr1 / 97064	MGIID:	1917649	Length:	452	Species:	Mus musculus

Alignment Length:	527	Identity:	100/527 - (18%)
Similarity:	164/527 - (31%)	Gaps:	224/527 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 SASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGS 521
            |.:||...|.|:          ||:|...:      |.||               :|:.||....
Mouse     4 STAPLSARLFPK----------GGSLLQTL------FMGQ---------------SGSRGGCARL 37

  Fly   522 PLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVV 586
            .|:|            ||.|.........|  |..:|.:|...|         ...||    :|:
Mouse    38 RLLC------------RLLAQWERPRPVPG--IKMNPSSVPHPL---------PPPGQ----QVI 75

  Fly   587 HI--------------------SSTRLPSIPER------SAAAAAAAAAAAAGAALMEPGTGTVS 625
            |:                    ||.|...:||.      |.:.:..::..::|.   .||.....
Mouse    76 HVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGG---HPGPRLAG 137

  Fly   626 GS---------------SGAGAAGEP------------------PLPPAWEARMDSHGRIFYIDH 657
            |:               :||||||.|                  ||||.||....:.|:.::::|
Mouse   138 GAQHVRSHSSPASLQLGTGAGAAGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNH 202

  Fly   658 TTRTTSWQRPGAAPSGGPAGREQHHRQQLDR--RYQSIRRTITNES--RAAQLYNLPTSANSN-- 716
            ..:.|:||.|               |:.:::  .:.::..:||:.|  :.:...:.|..|.::
Mouse   203 IEKITTWQDP---------------RKVMNQPLNHVNLHPSITSTSVPQRSMAVSQPNLAMNHQH 252

  Fly   717 ----ANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCF 777
                |.|.:|...|  |...|..||                 ::.|.....:....::|     .
Mouse   253 QQVVATSLSPQNHP--TQNQPTGLM-----------------SVPNALTTQQQQQQKLR-----L 293

  Fly   778 QRYQYNKDLV-----ALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR 837
            ||.|..::.:     .|:...|.:.|:||...||....:......|.:....|..||.|
Mouse   294 QRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMSTDMRSVTNSSSDPFL------ 352

  Fly   838 VVRHRQQHSQQQSS-----VGYY-----------------------------------YPDLVDG 862
              .....||::||:     :|.|                                   :||.:|
Mouse   353 --NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTRFPDFLD- 414

  Fly   863 NCLSATS 869
             ||..|:
Mouse   415 -CLPGTN 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	10/28 (36%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
Wwtr1	NP_001161753.1	WW	182..213	CDD:197736	12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810