DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and UBE3C

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_055486.2	Gene:	UBE3C / 9690	HGNCID:	16803	Length:	1083	Species:	Homo sapiens

Alignment Length:	501	Identity:	150/501 - (29%)
Similarity:	238/501 - (47%)	Gaps:	60/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   950 KVIAFLRQPNILEILRERQGQ-------HTMSRQLREKINILRVEGVPA------LERLGH--DL 999
            |||.     |::::|:.|..:       |.:|.|...|.:.:....|||      ..|:|.  .|
Human   603 KVIT-----NLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPL 662

  Fly  1000 QLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYR-----KLESK 1059
            |.|:.:.|             .||..|.....::......||...||.:::.|.|     |.|.:
Human   663 QSTLDVGL-------------ESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQ 714

  Fly  1060 GYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDT----EEGLDYGGPSREFFFL 1120
            |.|.....:.:.|||:::.|||:.::...|:.||::.....|.:.    |.|:|.||..|||...
Human   715 GDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNE 779

  Fly  1121 LSRELFNPYYGLFEYSANDTYTVQVSPLSAFV--DNCHDWFRFSGRVLGLALVHQYLLDAFFTRP 1183
            |.:..|||..|.|: :.|:. .:..:|.:..:  |:....:.|.||:||.||....|::..|...
Human   780 LLKSGFNPNQGFFK-TTNEG-LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGF 842

  Fly  1184 FYKALL--RLPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGSVVDRELKP 1244
            |...||  ...|.:..|.|||.|.:::|.:::  ::|:   .:|||.|.|....||.....|||.
Human   843 FLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDV---EELGLNFTVVNNDLGEAQVVELKF 904

  Fly  1245 GGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT-A 1308
            |||:|.:...|:..|:..:..:||.|.:::...:..:|...|:....:.:||.:|::::|:|. .
Human   905 GGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQV 969

  Fly  1309 EIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTG 1373
            .|...|.:..|.|..||..:|.||..||:|:|.|::|::.:||:|||..|..|..||..|..:
Human   970 PISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-- 1032

  Fly  1374 PRRFCIEKWGKP-NALPRAHTCFNRLDLPPYPTPELLYEKLLLAVE 1418
               |||...|.. ..||.|.||.|.|.||.:....||..|||.|:|
Human  1033 ---FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIE 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	118/363 (33%)
		HECTc	1092..1423	CDD:214523	111/339 (33%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		IQ	47..64	CDD:197470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..385
		HECTc	725..1081	CDD:238033	118/361 (33%)
		HECTc	747..1080	CDD:214523	111/339 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810