DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Hecw1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	1503	Identity:	581/1503 - (38%)
Similarity:	768/1503 - (51%)	Gaps:	300/1503 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GNESDELEQAFQ-SALTLTNDV-HVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEA 131
            ||..:.:.||.. |.::|..|| .:.|.:......|:..|            .||..::|.
Mouse   258 GNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKR------------FLGKLSMPV---- 306

  Fly   132 SLTGSKETREPRHHQTLLSTKSCETPANNATLS---PTNSYNGSI--GSDGGSSVGGGARRKSWT 191
                          |.||...:......:.||.   ||:..:|.:  ..:..||:.......|.:
Mouse   307 --------------QRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHADDEEISLS 357

  Fly   192 LSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARE-CFETVPAEMVDTLSMAEVDEEV 255
            ..|:|..         :|:.....:.:.|:||:...  .|.| |.:..|    ::.|........
Mouse   358 AEPESSA---------ETQDSIMNSMVGNSNGEPSG--DATEFCKDAKP----ESPSEGNGVNSS 407

  Fly   256 DEEEDEEAAAVESLLGAAAALQAS----AHVQRRQQQQHHQHLRQPS-----PPQHRPLERSWPP 311
            :.:..|.|..||...||..|...|    |..:..:.|...||..||:     ..:..||:...|.
Mouse   408 ENQNQEHAGPVEEAAGAMEARDGSNVSEAPEEPGELQDPEQHDTQPTLSAEEVAEGLPLDEDSPS 472

  Fly   312 RAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNN----SPL--ATPPVRFKPLLKKKIGPD 370
            ..:..:....|...:.:.:..:....|||.:|......    |.|  ..|.:..:..::||..|.
Mouse   473 SLLPEENTALGSKVEEETVPENGAREEEMQKGKDEEEEEEDVSTLEQGEPGLELRVSVRKKSRPC 537

  Fly   371 SYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEE-- 433
            |                 .|.....:.:.|:.....:.:..|:|.|..|....|..:.|::||
Mouse   538 S-----------------LPVSELETVIASACGDAETPRTHYIRIHTLLHSMPSAQRGSTTEEED 585

  Fly   434 ---------QASPR--------LLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGA 481
                     ::|.:        :...|:......|..:|...:|.|.|   ..|..:..:|:|..
Mouse   586 GLEEESTLKESSEKDGLSEVDTIAADPQSMEDGESDGATLCMAPSDCS---GGHFSSLSKGIGAG 647

  Fly   482 LQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATG--GATGSPLVCPPTPTHHARRHA------- 537
            ......|.|.:.....|||        ||.....|  .:..|| .|..|..:.:..::
Mouse   648 QDGEAHPSTGSESDSSPQQ--------GADHSCEGCDASCCSP-SCYSTSCYSSSCYSSSCYSSS 703

  Fly   538 ------RLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSI 596
                  |..:.|..||:.|  |..|:....|||.|         |:.:..:.|.|. .|.:.|.:
Mouse   704 CYNGNNRFASHTRFSSVDS--AKISESTVFSSQED---------EEEENSAFESVP-DSVQSPEL 756

  Fly   597 ---------PERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAA---GEP------------- 636
                     |.:...||....||.:...|..|..|..:...|....   .:|
Mouse   757 DPESTNGAGPWQDELAAPGGNAARSTEGLESPMAGPSNRREGECPILHNSQPISQLPSLRPEHHH 821

  Fly   637 ------PLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGR----EQHHRQQLDRRYQ 691
                  ||||.||||:|||||:||:||..|||:||||..||:  |.|.    ..|..:||:||||
Mouse   822 YPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPSMAPT--PDGMIRSGSVHQMEQLNRRYQ 884

  Fly   692 SIRRTITNESRAAQLYNLPTSANSNA------------------------------NSTAPAAPP 726
            :|:||:..| ||.:     .|.|.|:                              .|.:|....
Mouse   885 NIQRTMATE-RAEE-----DSGNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQ 943

  Fly   727 PATAI--HPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVAL 789
            ..|.:  .||:..:..|:|:::||.|.:|..::..:..||||::::|||...|:|||:|:|||..
Mouse   944 KVTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNF 1008

  Fly   790 VNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRH--RQQHSQQQSSV 852
            :|.||....|||..||.|.|..||.||:||..|.|:|:|||:|::..|:..|  .:||.|:..|
Mouse  1009 INMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRS- 1072

  Fly   853 GYYYPDLVDGNCLSATSGHINASPASSVS---GVPPLPPPRPSSS-SSSSRSSHGHGHNCNTTSA 913
                               .:|..||.||   |...|  .||..| .::.||.|.|
Mouse  1073 -------------------YSAGEASEVSRNRGASLL--ARPGHSLIAAIRSQHQH--------- 1107

  Fly   914 ISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLR 978
                                       |.:|:|||:|::||||||||.|:|:|||.....:..||
Mouse  1108 ---------------------------ESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLR 1145

  Fly   979 EKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEE---------------RSPQGSPV 1028
            |||:.:|.||...|::|..|..|.|||||||:|||.:||::.               .|||.||.
Mouse  1146 EKIHYIRTEGNHGLDKLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPG 1210

  Fly  1029 LNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDL 1093
            | .|...|||.|:|||||||||:||||||:||:||||.|:||.|||.||||..|.::|:.::|:|
Mouse  1211 L-QRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKEL 1274

  Fly  1094 QRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDW 1158
            ||.:|.:.:..||||||.|||||||||||:|||||||||||||||||||||:||:||||:|..:|
Mouse  1275 QRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEW 1339

  Fly  1159 FRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDL 1223
            ||||||:|||||:|||||||||||||||.||:||..|||||.||.||||||||::||:| |.: |
Mouse  1340 FRFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNI-TDI-L 1402

  Fly  1224 GLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVID 1288
            .|||.|.||:.|.|.:||||.||.|..:.|||||||:|||:|||:||||.:|||:|:||||||:|
Mouse  1403 DLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVD 1467

  Fly  1289 SRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQF 1353
            |||||||||||||||||||||||.||||.|||||.||||.|.||.|||..:|||:||||||||||
Mouse  1468 SRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQF 1532

  Fly  1354 VTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVE 1418
            ||||||:|||||:|||||.|.||||||||||..:|||||||||||||||||:..:||||||.|||
Mouse  1533 VTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVE 1597

  Fly  1419 ETNTFGIE 1426
            ||:|||:|
Mouse  1598 ETSTFGLE 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	21/28 (75%)
		HECTc	1068..1424	CDD:238033	266/355 (75%)
		HECTc	1092..1423	CDD:214523	253/330 (77%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073	22/113 (19%)
		Neuromodulin	378..500	CDD:369001	25/127 (20%)
		WW	829..858	CDD:366073	21/28 (75%)
		HECW1_helix	947..1013	CDD:375862	24/65 (37%)
		WW	1019..1050	CDD:197736	17/30 (57%)
		HECTc	1249..1603	CDD:238033	266/355 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I319
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	901	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm42496
orthoMCL	1	0.900	-	-		OOG6_105324
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860