DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and TRIP12

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	2086	Identity:	388/2086 - (18%)
Similarity:	632/2086 - (30%)	Gaps:	792/2086 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QAEGDDEEEEEEEEDDDDDPKEEEA---------FYEARNGNESDELEQAFQSALTLTNDVHVSV 93
            |.|..|.....|.:.....||::.:         .|...|...|.:..:|.|         |..
Human    87 QPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQ---------HTE- 141

  Fly    94 SEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEA-------------------------SL 133
            |..|.::|...|:.:.:    :|:|||.:...|..|:|                         |.
Human   142 SPSETNKPHSKSKKRHL----DQEQQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSG 202

  Fly   134 TGSKET--REPRHHQTLLSTKS-------CETPANNATLSPTNSYNGSIGSDGGSSVGGGAR--- 186
            :||:.|  .|.....|.|::||       |.|..::::.:.|:|.:.::.| ..|:|..|||
Human   203 SGSESTGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVAS-ASSTVPPGARVKQ 266

  Fly   187 ----------RKSWTLSP----------QSGGSTPLSGAKK--------KTKTGAPTTTLSNANG 223
                      |.:.:.||          ::|||:....|.:        |||...|.::.|..:.
Human   267 GKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSK 331

  Fly   224 DGFNLWVA---------RECFETVPAEMVD---------TLSMAEV------------------D 252
            .|.:...|         ::..|:.|||:..         |.|.|..                  :
Human   332 PGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQE 396

  Fly   253 EEVDEEEDEEAA------AVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPP 311
            :..|.|.::||.      ..|:..||||:...:..|......:......:....|.....|..||
Human   397 KMADPESNQEAVNSSAARTDEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALLEARGLPP 461

  Fly   312 RAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLL----KKKIG---P 369
            ...|........:|...|.......|:::.||..:|:.|......:....||    ::.:|   .
Human   462 HLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPV 526

  Fly   370 DSYINTISTQKVPVHQ-----------SYEFPTFPSSSAV------------------------- 398
            .|.:..:.|.....|.           :|.....|.||||
Human   527 KSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQAL 591

  Fly   399 -----------------------------GSSSSSPNSL-------------QFPYLRQHRP-LT 420
                                         .|.::..|:|             :|.::....| ||
Human   592 TALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLT 656

  Fly   421 RALSNGKASSSE---------------------EQASPRLLLSPKR--PRSPP------------ 450
            :.|::....|.|                     :.||..||.:.::  ..:||
Human   657 QRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVR 721

  Fly   451 ------SGCSTRSASPLDISLSPEQHSPTRGRGVGGALQ--DAVPPGTPTFHGQRPQQ------- 500
                  |.|.|.:...:..:::...|....|...|...:  |.||        :.||:
Human   722 MFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVP--------RSPQELYELTSL 778

  Fly   501 -----------------RLLKRVGGGAGAGATGGA------------------------------ 518
                             .:||:    ..|..|.||
Human   779 ICELMPCLPKEGIFAVDTMLKK----GNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVG 839

  Fly   519 ----------------------------TGSPLVCPPTP---------THHARRHARLQAVTANS 546
                                        |...:...|.|         :...:..||.|.:..:.
Human   840 EDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDP 904

  Fly   547 SLASG------GAI-----PSDPPAVSSQ-----LDYIYLQDGGQEQGQEQSDEVV-------HI 588
            .||..      |.:     .|..|||..:     |..||..|.      |...:|:       ||
Human   905 ELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADA------ELLKDVLKNHAVSSHI 963

  Fly   589 SS---------------------TRLPSI-----------------PERSAAAAAAAAAAAAGAA 615
            :|                     .:||.|                 .|..:...:...|...|:.
Human   964 ASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSG 1028

  Fly   616 LMEPGTGTVSGSSGAG--AAGEPPLPPAWEARMDS-----HGRIFYIDHTTRTTSWQRPGAAPSG 673
            .|...|...||::.|.  ||.:...|....:|.||     .||:..:....|         .|..
Human  1029 SMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKR---------LPKR 1084

  Fly   674 GPAGREQHHRQQLDRRY--QSIRRTITNESRAAQLYNL------PTSANSNANSTAPAAPPPATA 730
            ||. |.::...:.|.:.  |:...|.|...:::.|.:|      ..|..||:|:..||.....:.
Human  1085 GPR-RPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSG 1148

  Fly   731 I----------------------------------------HPAILML----------------- 738
            :                                        :||:.:|
Human  1149 LARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGG 1213

  Fly   739 --CRPDFYSLLHTNEAA------------LAIYNRNAALKHMVMRIRRDPPCFQRYQY------- 782
              |..:..|::..::.:            |.:|..:.:.|..|.|..|    .:|:.:
Human  1214 AECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIR----LKRFLHVFFSSPL 1274

  Fly   783 -------------NKDLVALV----NTFAQMSR------ELPSCWETKLDQSGK-----QFFIDH 819
                         |..|:|||    |..:||.:      :.||...|    .|:     :||..|
Human  1275 PGEEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGT----GGRGSQALKFFNTH 1335

  Fly   820 QHRRTSFMDPRLPVECPRV------------------------------VRHRQQHSQ------- 847
            |.:......|    :|..|                              ||...:.|.
Human  1336 QLKCQLQRHP----DCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEE 1396

  Fly   848 -QQSSVGYYYPDL------VDGNCLS------------ATSGHI---------------NASPAS 878
             .:|.|.||.|.:      |.|..|.            ..||::               |.:...
Human  1397 IDESLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQ 1461

  Fly   879 SVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAY-----GAAGMASAGAT-- 936
            :|............|:...|......|....|.:.....:..|..:.     |..|.|....|
Human  1462 AVRQFSIQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKT 1526

  Fly   937 ----AAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGH 997
                |..::::   :::.|...:..|..:.::.......|......:.|.:|||  :.|:.|..:
Human  1527 SPRNAKKHDEL---WHDGVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRV--LHAISRYWY 1586

  Fly   998 DLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRA---------------PP-------- 1039
            .|....:.    :||   :|..|       .:||::..:|               |.
Human  1587 YLYDNAMC----KEI---IPTSE-------FINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKT 1637

  Fly  1040 -PFRRDFEAKLRSFY--------------------RKLESKGYGQGPH--KLKLHIRRSHLLEDA 1081
             ||...|:.:...||                    .:.:|:.....|.  :.|..:.|..||:.|
Human  1638 CPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQA 1702

  Fly  1082 FRRIMSANKKDL--QRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLF----------E 1134
             ..:|    :||  .|..|.:.::.|.|... ||:.||:.|:|:||.....||:          :
Human  1703 -ESVM----QDLGSSRAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPK 1761

  Fly  1135 YSANDTYTVQ------VSPLS-----AFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKAL 1188
            .|...|..:|      ..|..     |.:......|||.|:::..|::...|:|.....||||.:
Human  1762 GSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWM 1826

  Fly  1189 LRLPVALS--DLESLD-----NEFH-------------------QSLQWIRDNDIGTGV---DLG 1224
            ||...:|:  ||..:|     :.:|                   :|||:..:.....|.   |||
Human  1827 LRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1891

  Fly  1225 LTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDS 1289
            |.|     .|....:.|||.|||:|.:...|.:|||..:|.|.|..||..|.:|...||..|...
Human  1892 LDF-----TLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1951

  Fly  1290 RLVSVFDARELELVIAGTAEIDTNDWRLNTEYR-----SGYHDNHQVIVWFWQVIERFSNEQRLR 1349
            ..:..|...||:.::.| ::.||  |...|...     .||..:.:.:.:.::::..|.|||:..
Human  1952 SHLQYFYPEELDQLLCG-SKADT--WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRL 2013

  Fly  1350 LLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKP-NALPRAHTCFNRLDLPPYPTPELLYEKL 1413
            .||||||:..:|..||.:|.......|...|....| :.||...||.|.|.||.|.:.|::.|||
Human  2014 FLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKL 2078

  Fly  1414 LLAVEE 1419
            |:|..|
Human  2079 LIAARE 2084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/33 (21%)
		HECTc	1068..1424	CDD:238033	119/410 (29%)
		HECTc	1092..1423	CDD:214523	113/386 (29%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680	28/147 (19%)
		Arm_3	489..>714	CDD:330530	32/224 (14%)
		WWE	808..874	CDD:308464	3/65 (5%)
		HECTc	1690..2090	CDD:238033	119/409 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810