DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and MAGI1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	1484	Identity:	275/1484 - (18%)
Similarity:	411/1484 - (27%)	Gaps:	564/1484 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DDPKEEEAFYEARNGNESDE-----LEQAFQSALTLTNDVHVSVSE-VEEHEPPLASRNQEVAEV 113
            |..||...|...|.|...::     |.|.||.. :..:::..::.: :..|..|..:|:....||
Human    91 DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKG-SPDHELQQTIRDNLYRHAVPCTTRSPREGEV 154

  Fly   114 E---------------EQQQQL--------GACALPQPSEASLTGSKETREPRH-------HQTL 148
            .               ||...|        .....|:|....::|...|.:..|       ..|.
Human   155 PGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTP 219

  Fly   149 LSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLS----PQSGGS---TPLSGAK 206
            ..|||.....|...:...|.....:.....|.......::..||.    |....|   .|::...
Human   220 KRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPS 284

  Fly   207 KKTKTGAPTTTLSN-------------ANGDGFNL--------WVARECFETVPAEMVDTLSMAE 250
            :|.....|.:...|             .||:.:.:        |:...|..    :....|...|
Human   285 QKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLN----KQQKPLEECE 345

  Fly   251 VDEEVDEEE-DEE---AAAVESLLGAAAALQASAHVQRR-----------------QQQQHHQHL 294
            .||.|..|| |.|   .|..|.:......:....|:.|:                 ||||..|..
Human   346 DDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQ 410

  Fly   295 RQPSPPQHRPLERSW---------------PPR--AVGRDLKLQGDV------------------ 324
            :|....|.:.....|               ||.  ...|::.|||..
Human   411 QQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKL 475

  Fly   325 ------FQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTIST----- 378
                  |.|.::..||  .:|..|......:.|.|         |..|:.....|.:::.
Human   476 RKSSRGFGFTVVGGDE--PDEFLQIKSLVLDGPAA---------LDGKMETGDVIVSVNDTCVLG 529

  Fly   379 ----------QKVPVHQSYEF-----------PTFPSSSAVGSSS---SSPNSL--QFPYLRQHR 417
                      |.:|:..|.:.           |..|::|.|.|.:   ..|..:  |..|   ..
Human   530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETY---DS 591

  Fly   418 PLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRS-ASPLD-------ISLSPE---QHS 471
            |.:.:...||.:..::          .||.||....|..| ..|.|       |:..||   .|.
Human   592 PASHSSKTGKVNGMKD----------ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHI 646

  Fly   472 PTRGRGVGGALQDAVPPGTPTFHGQRPQQ-------------RLLKRVGGGAGAGATGGATGSPL 523
            .....|.|..:.|     :|...|||.:|             .|:..|........|.......|
Human   647 VKGPMGFGFTIAD-----SPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDML 706

  Fly   524 V-CP--------------PTP------------------THHARRHARLQAVTANSSLASGGAIP 555
            | ||              |.|                  .|....|..|...:.:.|..   .:|
Human   707 VECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ---VLP 768

  Fly   556 SDPPAVSSQLDY-------------IYLQD------------------------------GGQEQ 577
            ..|||.:...|.             |:.|.                              ||.|.
Human   769 EFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEP 833

  Fly   578 GQ-------------------EQSDEVV--------------------------HISST------ 591
            |:                   ...||::                          |::.|
Human   834 GEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV 898

  Fly   592 -RLPSIPERSAAAAAAAAAAAAGAALME----------------PGTGTVSGSSGAGAAGEPPLP 639
             .:|.......:.|::..::...|:|.|                .|:|:.||....|..|...:.
Human   899 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVS 963

  Fly   640 PAWE------ARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHR-------QQLDR--- 688
            ...:      .|.::.|..|.|     .:|..||.|..:.|.|.....|:       ...||
Human   964 TVVQPYDVEIRRGENEGFGFVI-----VSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGK 1023

  Fly   689 -----RYQSIRR-TITNESRAAQLYNL-------------PTSANSNA----------------- 717
                 |..::.. :|||:|. :.:.||             |...:|||
Human  1024 LKVGDRILAVNGCSITNKSH-SDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1087

  Fly   718 ----------NSTAPA-------APPPATAIHPAILMLCRPDFYSL-LHTNEAALAIYNRNAALK 764
                      |:|.|.       ..|.||.         ..|||:: |...........|.....
Human  1088 PSQQGTQETRNTTKPKQESQFEFKAPQATQ---------EQDFYTVELERGAKGFGFSLRGGREY 1143

  Fly   765 HM---VMRIRRDPPCFQRYQYNK--DLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRT 824
            :|   |:|:..|.|. :|....:  |.:..:|  .:.::.:......:|.::|.:       |..
Human  1144 NMDLYVLRLAEDGPA-ERCGKMRIGDEILEIN--GETTKNMKHSRAIELIKNGGR-------RVR 1198

  Fly   825 SFM---DPRLPVECPRVVRH-----------------RQQHSQQQSSVGYYYPDLVDGNCLSATS 869
            .|:   |..:|...|...||                 |:||...:||   |.|||
Human  1199 LFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESS---YPPDL---------- 1250

  Fly   870 GHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAG 934
             |     .||..|........|..|...||..:.| |..|.||.     ..|..|......|..|
Human  1251 -H-----KSSPHGEKRAHARDPKGSREYSRQPNEH-HTWNGTSR-----KPDSGACRPKDRAPEG 1303

  Fly   935 ATAAGYEDVPIAYNEKVIAFLRQP-----------NILEILRERQGQHTMSRQL-----REKINI 983
            ...|..|....|...|    .|.|           |.|    ||:.:|...|.:     ||:...
Human  1304 RRDAQAERAAAANGPK----RRSPEKRREGTRSADNTL----ERREKHEKRRDVSPERRRERSPT 1360

  Fly   984 LRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQ----GSPVLNSRMPQRAPPPFRRD 1044
            .|.:|.|:..|..       |..|.||         .|||:    |||      .:||....||.
Human  1361 RRRDGSPSRRRRS-------LERLLEQ---------RRSPERRRGGSP------ERRAKSTDRRR 1403

  Fly  1045 FEAKLRSFYRKLESKG-YGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGR 1097
            ..:..|...|.|:.:. ..:..|:.:   ..::|.:||.|   |:.....||.|
Human  1404 ARSPERRRERSLDKRNREDRASHRER---EEANLKQDAGR---SSRHPPEQRRR 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/34 (15%)
		HECTc	1068..1424	CDD:238033	8/30 (27%)
		HECTc	1092..1423	CDD:214523	3/6 (50%)
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492	3/8 (38%)
		GuKc	122..293	CDD:214504	26/171 (15%)
		WW	303..332	CDD:238122	3/28 (11%)
		WW	361..390	CDD:278809	4/28 (14%)
		PDZ	469..555	CDD:214570	14/96 (15%)
		PDZ	640..723	CDD:214570	17/87 (20%)
		MAGI_u5	722..805	CDD:293271	13/85 (15%)
		PDZ_signaling	819..894	CDD:238492	8/74 (11%)
		PDZ_signaling	968..1062	CDD:238492	20/99 (20%)
		PDZ	1123..1205	CDD:214570	14/91 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900