DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and UFD4

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	461	Identity:	121/461 - (26%)
Similarity:	193/461 - (41%)	Gaps:	88/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1023 PQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYG------QGPHKLKLHIRRSHLLED- 1080
            |..|..|..|.      ||...|:.  |..:.:..|.|||      :...|....:|....|:.
Yeast  1039 PDWSLFLTRRF------PFLFPFDT--RMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQL 1095

  Fly  1081 --AFRRIMSANKKDLQRGRLAVL-------------WDTEEGLDYGGPSREFFFLLS----RELF 1126
              ..||.:..::|.:....|.:|             :..|.|... ||:.||:.::|    |:..
Yeast  1096 GRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGL-GPTLEFYSVVSKYFARKSL 1159

  Fly  1127 N-------PYYGLFEYSANDTYTVQV---SPLSAFVDN--CHDWFRFSGRVLGLALVHQYLLDAF 1179
            |       .|....:....|.|...:   .||:.|.:|  ..:.|.:.|..:..:|:...:||..
Yeast  1160 NMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFR 1224

  Fly  1180 FTRPFYKALLRL-----PVALSDLES-------LDNEFHQSLQWIRDN--DIGTGVDLGLTFCVT 1230
            |::.|::.|.|:     ....||:|:       :|....:||::|..|  |..|...|.|||.|.
Yeast  1225 FSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVP 1289

  Fly  1231 EELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVID-SRLVSV 1294
            ..     .|.||.|||.|..:|..|.:||:..:|...|.:|:::|.::.:.||.:|.. .|::.:
Yeast  1290 GN-----DDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLIL 1349

  Fly  1295 FDARELELV-IAGTAEIDTNDWRLNTEYRS-----GYHDNHQVIVWFWQVIERFSNEQRLRLLQF 1353
            |..   ||| |.|..|   .||.:.|.|.:     ||..:..:|..|..:|..|...:|...|||
Yeast  1350 FPD---ELVDIFGRVE---EDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQF 1408

  Fly  1354 VTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA-----LPRAHTCFNRLDLPPYPTPELLYEKL 1413
            :||:..:|..||.:|    .|:...:.|..:...     ||...||.|.|.||.|.:.:::..:|
Yeast  1409 LTGSPKLPIGGFKSL----NPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRL 1469

  Fly  1414 LLAVEE 1419
            ..|:||
Yeast  1470 CQAIEE 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	108/410 (26%)
		HECTc	1092..1423	CDD:214523	103/383 (27%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	121/461 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900