DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and HUL4

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	748	Identity:	172/748 - (22%)
Similarity:	273/748 - (36%)	Gaps:	225/748 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   757 YNRNAALK---HMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFID 818
            |..|.:.|   .::..:||.|.  ..:.|..:::.|...| |.||.|.:   ...:::.|.....
Yeast   288 YLSNLSTKTSQQLIQSLRRTPT--DNFSYQVEILNLYINF-QFSRLLSN---ELSNRTAKNNVKP 346

  Fly   819 HQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGV 883
            ....|:               |.|:.|                      |:||...|
Yeast   347 EDEMRS---------------RLRRHH----------------------TTGHEFLS-------- 366

  Fly   884 PPLPPPRPSSSSSSSRSSHG--------------------HGHNCNTTSAISCALNADRSAYGAA 928
                 .||.|:.|:.:...|                    |.|:....:.|....|..|:..||.
Yeast   367 -----TRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRRNGRGAL 426

  Fly   929 GMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQG-QHTMSRQLREKINILRVEGVPAL 992
            .:.|             .||          ..|:.:..:|. .|......:.|:|.|       :
Yeast   427 SIQS-------------FYN----------ITLDFIDYKQDFDHWRGVAQKTKMNQL-------I 461

  Fly   993 ERLGHD--------------LQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRR 1043
            |..|:.              |.|.|.:|:.|.||                             ||
Yeast   462 EEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEI-----------------------------RR 497

  Fly  1044 DFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGL 1108
            ..|.:....:.....||.....: .|:.:||..:..|:.|.| ..::.||.:. |.:.:..|.|:
Yeast   498 IMEHEAEQAFLISLDKGKSVDVY-FKIKVRRDVISHDSLRCI-KEHQGDLLKS-LRIEFVNEPGI 559

  Fly  1109 DYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFS----------- 1162
            |.||..:|:||||::.||||..|||.|               ..::...||...
Yeast   560 DAGGLRKEWFFLLTKSLFNPMNGLFIY---------------IKESSRSWFAIDPPNFDKSKGKN 609

  Fly  1163 ---------GRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS----LQWIRD 1214
                     |.|:|||:.:..:||..|.:..||.|...|::..|...|..|..::    |.:..|
Yeast   610 SQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTED 674

  Fly  1215 N--DIGTGVDLGLTFCVT----------EELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWR 1267
            |  |:     ..|||..|          .:.....|..||...|:|:.|.:.||.|::.:.:::.
Yeast   675 NFEDV-----FSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFY 734

  Fly  1268 LERGVQEQTESLVRGFYEVI-DSRLVSVFDARELELVIAGTAE---IDTNDWRLNTEYRSGYHDN 1328
            ||:.::.|....|.||..|. :...:.:|::.|||.::.|..|   .|....|..|:|..|:.|:
Yeast   735 LEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDD 799

  Fly  1329 HQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA--LPRA 1391
            .:.:.|||::||.:....:.:||||||.:..||..|.|.:       .|.|...|..::  ||.|
Yeast   800 SRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTI-------PFKISLLGSHDSDDLPLA 857

  Fly  1392 HTCFNRLDLPPYPTPELLYEKLLLAVEETNTFG 1424
            |||||.:.|..|.:.:.|..|||.|:.|:..:|
Yeast   858 HTCFNEICLWNYSSKKKLELKLLWAINESEGYG 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	114/397 (29%)
		HECTc	1092..1423	CDD:214523	108/372 (29%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	172/748 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810