DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and HUL5

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	449	Identity:	134/449 - (29%)
Similarity:	199/449 - (44%)	Gaps:	56/449 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1019 EERSPQGSPVLNSRMPQRAPP-------------PFRRDFEAKLRSFYR--KLESKGY------- 1061
            :||.|..|.:|| :|.:|...             ||...||.::..||.  .|:.|..
Yeast   475 KERPPLKSLLLN-KMKKRLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHN 538

  Fly  1062 ---------GQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVL----WDTEEGLDYGGP 1113
                     ..|..|....|.|.::|||||....|..::  .:..|.|.    :..|.|:|.||.
Yeast   539 LINMFTPWASTGMRKQSAIISRDNVLEDAFNAFNSIGER--FKASLDVTFINEFGEEAGIDGGGI 601

  Fly  1114 SREFFFLLSRELF-NPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLD 1177
            ::||...:|.|.| :|.:.||.  .||.|.:..|.:.......:.|  |.|:|:|..|....|:|
Yeast   602 TKEFLTTVSDEGFKDPKHELFR--TNDRYELYPSVVYDATKLKYIW--FLGKVVGKCLYEHVLID 662

  Fly  1178 AFFTRPFYKALLRLP----VALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTE-ELLGSV 1237
            ..|...|.|.||...    .:.|||.|.|:..:.:|..:.:........|.|||.:.| |....|
Yeast   663 VSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKV 727

  Fly  1238 VDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELEL 1302
            ||  |.|.|....:.:.|...|:.::..::|.:...:...:...|...:|....:.:|::.||::
Yeast   728 VD--LIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQM 790

  Fly  1303 VIAGTAE-IDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFS 1366
            :|:|..: ||.:|.:.|||| .||.:..|.||.||:|:..|..|::|..|:|||.....|.:||.
Yeast   791 LISGERDNIDLDDLKSNTEY-GGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFK 854

  Fly  1367 ALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGI 1425
            ||....|.|....||:    .||.|.||.|.|.||.|....:|.||||.|:.....|.:
Yeast   855 ALDPKFGIRNAGTEKY----RLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	115/366 (31%)
		HECTc	1092..1423	CDD:214523	107/341 (31%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	134/449 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810