Protein Alignment Hecw and UPL1

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001185245.1
• Gene: UPL1 / 842036
• AraportID: AT1G55860
• Length: 3681
• Species: Arabidopsis thaliana
• Alignment Length: 1628
• Identity: 371/1628 - (22%)
• Similarity: 598/1628 - (36%)
• Gaps: 528/1628 - (32%)

  Fly    11 QP--LAASSACLADR---------SPVDPIAVR------LQQE-----------EQAEGDDEEEE 47
            ||  |:||.|.|.:.         :||:.:..|      :|::           |...||..|..
plant  2366 QPSSLSASIAQLIEEHFISNLRASAPVNTVVERETNTTEIQEQLHPDVPPSVGSETVLGDGNEGG 2430

  Fly    48 EEEEDDDDDPKEEEAFYEARNGNES-----DELEQAFQS-----ALTLTNDVHVSVSEVEEHEP- 101
            ::.|:           .|..|.||:     |.:.::|..     |..::.|...|:.::|..:|
plant  2431 QQSEE-----------RELLNNNENVNNPPDVMAESFAQGQANLASPVSQDTGESLQQLEVMQPL 2484

  Fly   102 PLASRNQE-------------VAEVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKS 153
            ||.|...|             :.:|:.:...|.:.|..||..:|:..             :|..:
plant  2485 PLNSTPNEIDRMEVGEGDGAPIDQVDHEAVHLISTAQGQPDTSSIQN-------------VSVTA 2536

  Fly   154 CETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTL 218
            ...|.::    |.:::..|:..|..|....|         .||...:||.|...:..:...|..:
plant  2537 IAPPVDD----PDSNFQPSVDVDMSSDGAEG---------NQSVQPSPLDGDNNELSSMEATENV 2588

  Fly   219 SNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDE----EAAAVESLLGAAAALQAS 279
            .|                               ||:|:|...:    |..|::.....|......
plant  2589 RN-------------------------------DEQVEEGSLDGRAPEVNAIDPTFLEALPEDLR 2622

  Fly   280 AHVQRRQQQQHHQHLRQPSPPQHRPLERSWPP---------RAVGRDLKLQGDVFQFDILDTDER 335
            |.|...||.|..|      ||.:.|     ||         .|:..|:       |.::| ..:|
plant  2623 AEVLASQQAQSVQ------PPTYEP-----PPVDDIDPEFLAALPPDI-------QTEVL-AQQR 2668

  Fly   336 LAEEMAQGSGSS----NNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSS 396
            ....:.|..|.:    |.|.:||.|...:                           |.....||.
plant  2669 AQRMVQQSQGQAVDMDNASIIATLPADLR---------------------------EEVLLTSSE 2706

  Fly   397 AVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPL 461
            ||.::..||...:...||.     ||:|:.:|.||...:|.||       .:..:|......:.:
plant  2707 AVLAALPSPLLAEAQMLRD-----RAMSHYQARSSVFGSSHRL-------NNRRNGLGYNRLTGM 2759

  Fly   462 DISLSPEQHSPTRGRGVGGAL-QDAVP-----------PGTPTFH-----------------GQR 497
            |             ||||..: |.||.           .|.|..:                 |:.
plant  2760 D-------------RGVGVTIGQRAVSSSADGLKVKEIEGDPLVNADALKSLIRLLRLAQPLGKG 2811

  Fly   498 PQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHAR----RHARLQAVTANSSLASGGAIPSDP 558
            ..||||..:...:...|........::.|...|..:.    ...||....:|........:...|
plant  2812 LLQRLLLNLCAHSFTRANLVQLLLDMIRPEMETSPSELAITNPQRLYGCQSNVVYGRSQLLNGLP 2876

  Fly   559 PAV---------------SSQLDYIYLQDG---GQEQGQEQSDEVVHISSTRLPSIPERSAAAAA 605
            |.|               |:..|.::..|.   .|...::..::|.|::.:|...||
plant  2877 PLVFRRVLEVLTYLATNHSAVADMLFYFDSSLLSQLSSRKGKEKVTHVTDSRDLEIP-------- 2933

  Fly   606 AAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSH-----GRIFYIDHT--TRTTS 663
                ......|:                ..|.|     .:..||     |.:..:.:|  :|...
plant  2934 ----LVVFLKLL----------------NRPQL-----LQSTSHLGLVMGLLQVVVYTAASRIEG 2973

  Fly   664 WQRPGAAPSGG--------PAGREQHHRQQLDRRYQSIRR---TITNESRAAQLYN----LPTSA 713
            |     :||.|        |.|.|.....:.|...:.:..   ::......|::||    ||.|.
plant  2974 W-----SPSSGVPEKLENKPVGEEASSETRKDAESELVGEADLSVARRKNCAEIYNIFLQLPQSD 3033

  Fly   714 NSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQ 778
            ..|                     ||     .||.....:..||    :|...|::.........
plant  3034 LCN---------------------LC-----ILLGYEGLSDKIY----SLAGEVLKKLAAVDVAH 3068

  Fly   779 RYQYNKDLVALVNTFAQMS-RELPSCWETKLDQSGKQFFIDHQHRRTSFM-------------DP 829
            |..:.|:|..|.::.:..: |||.:.       |.||    ...|.|..|             ..
plant  3069 RKFFTKELSELASSLSSSTVRELATL-------SSKQ----KMSRSTGSMAGASILRVLQVLSSL 3122

  Fly   830 RLPVECPRVVRHRQQHSQQQS-------SVGYYYPDLVDGNCLSATSGHI-------NASPASSV 880
            ..|::...|...|:...::|:       ::...:.:|  ..|:|.|...:       |.:|...|
plant  3123 TSPIDESNVGTERETEQEEQNIMQRLNVALEPLWHEL--SQCISMTELQLDHTAAASNINPGDHV 3185

  Fly   881 SGVPPLPPPRPSS-----------------------------SSSSSRSSHGHGHNCNTTSAISC 916
            .|:.|.....|.:                             ::...:.|..||.:..|
plant  3186 LGISPTSSLSPGTQRLLPLIEAFFVLCEKIQTPSMLQQDTNVTAGEVKESSAHGSSSKT------ 3244

  Fly   917 ALNADRSAYGAAGMASAGATAAGYEDVPIAYNEK----VIAFLRQ-PNILEILRERQGQHTMSRQ 976
            ::::.:...|:...:.              :.||    :.:|:|| |::||        .::|..
plant  3245 SVDSQKKTDGSVTFSK--------------FAEKHRRLLNSFIRQNPSLLE--------KSLSMM 3287

  Fly   977 LREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPF 1041
            |:                                                            .|.
plant  3288 LK------------------------------------------------------------APR 3292

  Fly  1042 RRDFEAKLRSFYRKLESKGYGQ---GPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWD 1103
            ..||:.| ::::|......:.|   ||  |::.:||:::|||::.::...:.:|| :|||.|.:.
plant  3293 LIDFDNK-KAYFRSRIRHQHDQHISGP--LRISVRRAYVLEDSYNQLRMRSPQDL-KGRLNVQFQ 3353

  Fly  1104 TEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGL 1168
            .|||:|.||.:||::.||||.:|:....||....||. |.|.:|.|.:......:|:|.||::..
plant  3354 GEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDA-TFQPNPNSVYQTEHLSYFKFVGRMVAK 3417

  Fly  1169 ALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEE- 1232
            ||....|||.:|||.|||.:|.:.|...|:|::|.:::::|:|:.:||:...:||..:....||
plant  3418 ALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWLLENDVSDILDLTFSMDADEEK 3482

  Fly  1233 -LL---GSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVS 1293
             :|   ..|.|.||||||:||.:.|:.|.||::.:....|...::.|..:.:.||.|:|...|||
plant  3483 HILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLEGFNELIPRELVS 3547

  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358
            :|:.:||||:|:|..|||.:|.:.||||.| |.....||.|||:|::.||.|...|.||||||||
plant  3548 IFNDKELELLISGLPEIDFDDLKANTEYTS-YTAGSPVIHWFWEVVKAFSKEDMARFLQFVTGTS 3611

  Fly  1359 SIPYEGFSALRGSTGPRRFCIEK-WGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNT 1422
            .:|.|||.||:|.:||:|..|.| :|.|..||.||||||:||||.|.:.|.|.|:||||:.|.:.
plant  3612 KVPLEGFKALQGISGPQRLQIHKAYGAPERLPSAHTCFNQLDLPEYQSKEQLQERLLLAIHEASE 3676

  Fly  1423 -FG 1424
             ||
plant  3677 GFG 3679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	36/198 (18%)
		WW	638..667	CDD:459800	7/35 (20%)
		HECW1_helix	738..794	CDD:465766	12/55 (22%)
		HECTc	1068..1424	CDD:238033	155/362 (43%)
UPL1	NP_001185245.1	DUF908	88..357	CDD:428721
		DUF913	418..763	CDD:461803
		UBA_atUPL1_2_like	1273..1310	CDD:270512
		UBM	2603..2631	CDD:464159	6/27 (22%)
		UBM	2641..2672	CDD:464159	8/43 (19%)
		HECTc	3319..3679	CDD:238033	155/362 (43%)