DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and ITCH

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001244066.1 Gene:ITCH / 83737 HGNCID:13890 Length:903 Species:Homo sapiens


Alignment Length:1175 Identity:335/1175 - (28%)
Similarity:491/1175 - (41%) Gaps:379/1175 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   298 SPPQHRPLE-----------RSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSP 351
            ||...:||.           |.|..:.:..|:.|  .....||.:|.:            |||..
Human    62 SPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLL--GTAALDIYETLK------------SNNMK 112

  Fly   352 LATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQH 416
            |.      :.::..::|.|         |.|            :..:|..|...:.||..     
Human   113 LE------EVVVTLQLGGD---------KEP------------TETIGDLSICLDGLQLE----- 145

  Fly   417 RPLTRALSNGKASSSEEQAS---PRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSP---TRG 475
               :..::||:.:.||...|   |||            .|::..::..::.|.....||   :|.
Human   146 ---SEVVTNGETTCSENGVSLCLPRL------------ECNSAISAHCNLCLPGLSDSPISASRV 195

  Fly   476 RGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGG-----AGAGATGGATGSPLVCPPTPTHHARR 535
            .|..||.|:.        .|.|.:........|.     ||||.....:|:              
Human   196 AGFTGASQND--------DGSRSKDETRVSTNGSDDPEDAGAGENRRVSGN-------------- 238

  Fly   536 HARLQAVTANS-SLASGGAIPSDPPAVS----------SQLDYIYLQDGGQEQGQEQSDEVVHIS 589
                     || ||::||..||.||..|          :.::       |......:||.    |
Human   239 ---------NSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVN-------GSPSATSESDG----S 283

  Fly   590 STRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSG---AGAAGEPPLPPAWEARMDSHGR 651
            ||  .|:|..:.....:..|.   :.|:.|  .|:||.||   .....:.||||.||.|:|.|||
Human   284 ST--GSLPPTNTNTNTSEGAT---SGLIIP--LTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR 341

  Fly   652 IFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRY--QSIRRTITNESRAAQLYNLPTSAN 714
            ::|:||..:.|:|.||...|.|.     :.....:.|.|  ....||.|.:              
Human   342 VYYVDHVEKRTTWDRPEPLPPGW-----ERRVDNMGRIYYVDHFTRTTTWQ-------------- 387

  Fly   715 SNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQR 779
                                     ||...|:.:..:..|.......|::..          .||
Human   388 -------------------------RPTLESVRNYEQWQLQRSQLQGAMQQF----------NQR 417

  Fly   780 YQY-NKDLVALVNTFAQMSRE------LPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR 837
            :.| |:||.|     ...|:|      ||..||.:.|.:|:.:|::|..|.|.:.|||       
Human   418 FIYGNQDLFA-----TSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPR------- 470

  Fly   838 VVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSH 902
                                          :.|.:|..         |||               
Human   471 ------------------------------SQGQLNEK---------PLP--------------- 481

  Fly   903 GHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRER 967
                                               .|:|                          
Human   482 -----------------------------------EGWE-------------------------- 485

  Fly   968 QGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSR 1032
                     :|     ..|:|:|..  :.|:.:.|..             |:.|:  |...|::.
Human   486 ---------MR-----FTVDGIPYF--VDHNRRTTTY-------------IDPRT--GKSALDNG 519

  Fly  1033 MPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGR 1097
             ||.|   :.|||:||::.|....:....   |..:|:.:.|..|.||:|::|||.:.:||:| |
Human   520 -PQIA---YVRDFKAKVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-R 576

  Fly  1098 LAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRF 1161
            |.|::..||||||||.:||:|||||.|:.||.|.||||:..|.|.:|::|.| :::..| .:|||
Human   577 LWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPAS-YINPDHLKYFRF 640

  Fly  1162 SGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLT 1226
            .||.:.:||.|...:|..|:.||||.:|..||.|.||||:|.||:.||.|:::|:| ...||.:.
Human   641 IGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNI-EECDLEMY 704

  Fly  1227 FCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRL 1291
            |.|.:|:||.:...:|||.|.||::.|:||:||:..:.:|||.|||:|||::...||.|::..:.
Human   705 FSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQY 769

  Fly  1292 VSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTG 1356
            :..|||:|||:::.|..|||.|||:.:..||. |....:.|:||||.::...||:|:||||||||
Human   770 LQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTG 833

  Fly  1357 TSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETN 1421
            |..:|..||:.|.||.||::|||||.||.|.|||:||||||||||||.:.|.|.||||.|:|||.
Human   834 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETE 898

  Fly  1422 TFGIE 1426
            .||.|
Human   899 GFGQE 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 15/28 (54%)
HECTc 1068..1424 CDD:238033 178/356 (50%)
HECTc 1092..1423 CDD:214523 169/331 (51%)
ITCHNP_001244066.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988 21/118 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..301 31/147 (21%)
WW 328..357 CDD:306827 15/28 (54%)
HUL4 <359..903 CDD:227354 241/766 (31%)
Required for interaction with FYN. /evidence=ECO:0000269|PubMed:16387660 395..471 24/127 (19%)
MAP kinase docking site. /evidence=ECO:0000250 574..583 4/9 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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