Protein Alignment CG42797 and WWC2

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_011530571.1
• Gene: WWC2 / 80014
• HGNCID: 24148
• Length: 1216
• Species: Homo sapiens
• Alignment Length: 1138
• Identity: 197/1138 - (17%)
• Similarity: 314/1138 - (27%)
• Gaps: 500/1138 - (43%)

  Fly   633 AGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRP---------------GAAPSGGPAG----- 677
            :|:.|||..||...|..|::|||||.||.|||..|               ...|.|..||
Human     7 SGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQI 71

  Fly   678 -----------------REQHHRQQ--LDRRYQSIRRTITNESRAAQLYNLPT------------ 711
                             |:|...:|  :.:.|.|:.:......:  :||::..
Human    72 GVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQK--ELYHVKEQRLALALDEYVR 134

  Fly   712 -----SANSNANSTAPAAPPPATAIHPAIL------------------------MLCRPDFYSLL 747
                 ...|:::::..:....:|...|.||                        :|.:...:..|
Human   135 LNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETL 199

  Fly   748 --------------HTNEAALAIYNRNAALK-----------------------HMVMRIRRDPP 775
                          ..:||...:....:..|                       |:...|.|..|
Human   200 QQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEP 264

  Fly   776 -----------CFQR------------------------------YQYNKDLVALVNTFAQMSRE 799
                       |..|                              .||.:...::.|...::|:.
Human   265 DLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKL 329

  Fly   800 LPSCWETKLD-QSGKQFFIDHQH---RRTSFMDP--RLPVECPRVVRHRQQHSQQQSSV------ 852
            ....|...|| :..|...|:.:.   :...|:.|  |...|..|:...||:..::..||
Human   330 DSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSR 394

  Fly   853 --------------------------GYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRP 891
                                      .|.:..|   ..|||::  ::.|..||:..:       .
Human   395 ALAERLRLEERRKELLQKLEETTKLTTYLHSQL---KSLSAST--LSMSSGSSLGSL-------A 447

  Fly   892 SSSSSSSRSSHGHGHNCNTT----SAISCALNAD-----------RSAY---------------- 925
            ||..|.:.||.|..::.::|    |:.|..::.|           :|.|
Human   448 SSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVK 512

  Fly   926 -----GAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILR 985
                 |.:|:....|.|.|:.. |:|...|.:|.|...:.|..|
Human   513 SPSQPGQSGLCGVAAAATGHTP-PLAEAPKSVASLSSRSSLSSL--------------------- 555

  Fly   986 VEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSP-VLNSRMPQRAP-----PPFRRD 1044
                                                ||.||| ||....|..:.     ..|..|
Human   556 ------------------------------------SPPGSPLVLEGTFPMSSSHDASLHQFTAD 584

  Fly  1045 FE-AKLRSFYRKL-----------ESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGR 1097
            || .:|.|.:..:           :|.|..|.            |.||          |||....
Human   585 FEDCELSSHFADISLIENQILLDSDSGGASQS------------LSED----------KDLNECA 627

  Fly  1098 LAVLWDTEEGLDYGGPSREFFFLL-----------SRELFNPYYGLFE-------------YSAN 1138
            ...|::....::...|.|....||           |.|......|::|             ||..
Human   628 REPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEE 692

  Fly  1139 DTYTVQVSPLSAFVDNCHDWFRFSGR-------VLGLALVHQYLLDAFFTRPFYKALLRLPVALS 1196
            |...|:.:.:..       ..|::.:       :..|..:|.:|:.  .|...|..:..|| :.:
Human   693 DVAIVETAQVQI-------GLRYNAKSSSFMVIIAQLRNLHAFLIP--HTSKVYFRVAVLP-SST 747

  Fly  1197 DLESL-DNEFHQSLQWIRDNDI--------------------------------GTGVDL----- 1223
            |:..| ..:.|...:.|..||:                                ||.:.|
Human   748 DVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLPF 812

  Fly  1224 -GLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI 1287
             ...|.:...||.|    :..|..|    ||:|             |..|.:..:.||    :.|
Human   813 SSEVFTLWYNLLPS----KQMPCKK----NEEN-------------EDSVFQPNQPLV----DSI 852

  Fly  1288 DSRLVSVFDARELELVIAGTAEI---------------DTNDWRLNTEYRSGYHDNHQVIVWFWQ 1337
            |...||...||....::|...|:               ...|| |||.:           :..|:
Human   853 DLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDW-LNTYF-----------LCCWE 905

  Fly  1338 ----VIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNR- 1397
                |..|.:.:..|.:|:..:.......|....|...:.    |.|......::|..:...||
Human   906 LKDDVFTRLTVKPLLTMLREASDEIVAEKEAEVKLPEDSS----CTEDLSSCTSVPEMNEDGNRK 966

  Fly  1398 -----LDL---PPYPTPELLYEKLLLAVEETNT 1422
                 .||   ||...|.|:       .:||||
Human   967 ESNCAKDLRSQPPTRIPTLV-------DKETNT 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	16/28 (57%)
		HECTc	1068..1424	CDD:238033	84/453 (19%)
		HECTc	1092..1423	CDD:214523	80/429 (19%)
WWC2	XP_011530571.1	WW	12..41	CDD:278809	16/28 (57%)
		WW	59..88	CDD:278809	4/28 (14%)
		DUF342	<283..385	CDD:302792	16/101 (16%)
		YlqD	351..>428	CDD:287979	11/79 (14%)
		C2_Kibra	700..823	CDD:176062	18/132 (14%)
		vWFA	<1058..>1153	CDD:294047
		Phage_Nu1	<1117..1192	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900