DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and herc5.2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	405	Identity:	112/405 - (27%)
Similarity:	181/405 - (44%)	Gaps:	50/405 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1040 PFRRDFEAKLRSFYRKLESKGYGQGPHKL-------KLHIRRSHLLEDAFRRIMSANKKDLQRGR 1097
            ||..|:.:| |..:..||.|...:..::.       .|||.|..||.|..:.:...........|
Zfish   615 PFVADYASK-RGIFNHLEIKMIRRSSNRFLGNATFNVLHINRESLLMDTLKYLRQNTHSFSHLSR 678

  Fly  1098 LAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDW---- 1158
            :|.:  .|:|:|..|.|.|||.|:|:          .:...|...::|.|.|....|.|..
Zfish   679 VAFI--GEDGIDMRGLSAEFFSLISK----------SFLKWDKKILEVHPSSLVWFNPHHTRGNK 731

  Fly  1159 -FRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWI--RDNDIGTG 1220
             |.:.|.:.|:||.:::.::..|....:|.||:...:|.|||.|.....:||:.:  .|.::
Zfish   732 NFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLKEDEEV--- 793

  Fly  1221 VD-LGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFY 1284
            || |.|.|        :|...||.|.|..|.:|:.|:::|::..:.:...:.|:.|.|...|||.
Zfish   794 VDLLFLDF--------TVKGHELVPNGSQIQVNKVNRQKYVDLYVDFVFNKSVKTQFEQFTRGFS 850

  Fly  1285 EVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLR 1349
            :.......::|...||:.::.|:.:.:..:::.:..| .|...:.::|..||.|....|.|.:.:
Zfish   851 KGCPLDAWTMFHPEELQELLHGSPQYNWKEFQQSASY-EGCSASDELIKNFWTVFFELSEEHKKK 914

  Fly  1350 LLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA---LPRAHTCFNRLDLPPYPTPELLYE 1411
            .|.|:.||..:|..|||       .||..|.....|:.   ||:|.|||.||.||.|.....|..
Zfish   915 FLMFLYGTERVPAGGFS-------KRRIKISTRDCPDPDDHLPKAQTCFGRLVLPKYTDINTLRN 972

  Fly  1412 KLLLAVEETNTFGIE 1426
            ||..|:.....||:|
Zfish   973 KLTHAINVCEVFGLE 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	101/373 (27%)
		HECTc	1092..1423	CDD:214523	94/341 (28%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274
		RCC1	136..186	CDD:278826
		RCC1	189..238	CDD:278826
		RCC1	242..290	CDD:278826
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058	101/366 (28%)
		HECTc	678..984	CDD:214523	94/336 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810