DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and ube3a

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	707	Identity:	175/707 - (24%)
Similarity:	283/707 - (40%)	Gaps:	183/707 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   874 ASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNAD--RSAYG--------AA 928
            ||.:|:...|.|     .:|:||...||||. :|......:..:::.|  |..|.        .|
Zfish   178 ASGSSTAMEVEP-----EASASSGDGSSHGE-NNVQKLGPVEVSVDIDAVRRVYDRLLSNEKIEA 236

  Fly   929 GMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHT--------------MSR---- 975
            ...:|....:...:..:.|:....|.....|:..|:.|....|:              ||:
Zfish   237 AFLNALVYLSPNVECDLTYHNVYAADPNYLNVFIIVMENSNLHSPEYLEIALPQFCKAMSKLPLP 301

  Fly   976 ---------------QLREKINILRV--------------------EGVPALER----------L 995
                           |:|..:...:.                    :||.|..:          |
Zfish   302 ALAKLARLWSQYGVDQIRRLVETFQQLITYTVISNEFSSDNLVNEDDGVVAATKCLKIVYYANVL 366

  Fly   996 GHDL-----------------QLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPP---- 1039
            |.||                 :||:      ||::|.....::.|:..| |.:.|..||..
Zfish   367 GGDLDTDHNEEDDDEPIPESSELTL------QELLGEERRNKKGPRVDP-LETEMGIRASDCRKP 424

  Fly  1040 --PFRRDFEAKLR---------SFYR-KLESK--------------------------------- 1059
              ||.......|.         :|:: :.|||
Zfish   425 LIPFEEFINEPLNEVLEMDKDYTFFKVETESKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRI 489

  Fly  1060 --------GYGQGPHKLKLHIRRSHLLEDAFRR---IMSANKKDLQRGRLAVLWDTEEGLDYGGP 1113
                    |....|: |:|.:||.|:::||..|   |...|..||:: :|.|.::.|:|:|.||.
Zfish   490 TALYSLVQGQQLNPY-LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYVEFEGEQGVDEGGV 552

  Fly  1114 SREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178
            |:|||.|:..|:|||..|:|.|. ..|.....:| |:|.:  ...|...|.|||||:.:..:||.
Zfish   553 SKEFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNP-SSFEN--EGQFTLIGIVLGLAIYNNCILDV 613

  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTE-ELLGSVVDREL 1242
            .|....|:.|:.......||........|||:.:.:.:.....|:.:||.::: :|.|:.:..:|
Zfish   614 HFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPLMYDL 678

  Fly  1243 KPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI-DSRLVSVFDARELELVIAG 1306
            |..|..|.:..:|:|:::....::.|.:.|::|.::..|||:.|. :|.|..:|...|:||:|.|
Zfish   679 KESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICG 743

  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALR-- 1369
            :..:|......:|||..||:.:.::|..||:.:..|..|::...|||.|||...|..|...|:
Zfish   744 SRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLKMI 808

  Fly  1370 -GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGI 1425
             ...||         ..:.||.:|||||.|.||.|.|.|.|.|:||.|:.....||:
Zfish   809 IAKNGP---------DSDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGFGM 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	118/363 (33%)
		HECTc	1092..1423	CDD:214523	108/335 (32%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166
		HECTc	505..855	CDD:238033	118/363 (33%)
		HECTc	532..854	CDD:214523	108/335 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810