DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and ube3b

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001072875.1	Gene:	ube3b / 780337	XenbaseID:	XB-GENE-1010563	Length:	1072	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	140/467 - (29%)
Similarity:	226/467 - (48%)	Gaps:	56/467 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   995 LGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFR----RDFEAKLRSFYRK 1055
            |..||:.|:|.    ||:       ::..:.:.:|...:|...|...|    |:...|.:.....
Frog   621 LRKDLKPTLLF----QEL-------DKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGL 674

  Fly  1056 LESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAV-----LWDTEEGLDYGGPSR 1115
            :|:.  ...||...:.||||.:|||.:.::...: ::..:|.:.|     |...|.|:|..|..:
Frog   675 VETN--TASPHVTHITIRRSRMLEDGYDQLRQLS-QNAMKGVIRVKFVNDLGVDEAGIDQDGVFK 736

  Fly  1116 EFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFF 1180
            ||...:.:.:|:|...||:.:::.. .:..||.|...:|....|.|.|::||.|:....::|..|
Frog   737 EFLEEIIKRVFDPALNLFKTTSSGD-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPF 800

  Fly  1181 TRPFYKALLR-----LPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGSVV 1238
            ...|...||.     ...::.:|.|||:||:::|..|:  |.||.   |||||....|:::|.:|
Frog   801 ASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDIS---DLGLTLSYDEDVMGQLV 862

  Fly  1239 DRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELV 1303
            ..||.||||:|.:..:||..|:..|..:|:...::.||.:.:.||..:|....:.:|.|.||:.:
Frog   863 CHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRL 927

  Fly  1304 IAG-TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIER-FSNEQRLRLLQFVTGTSSIPYEGFS 1366
            |:| .||||.:|.:.:|.|..|:|.:|:||:|.|.::.. ||:|::...|:|||..|..|..||:
Frog   928 ISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFA 992

  Fly  1367 ALR--------------------GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYE 1411
            .|:                    ||.....|.|.|......||.:.||||.|.||.|....:|.|
Frog   993 YLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKGILRE 1057

  Fly  1412 KLLLAVEETNTF 1423
            ||..|:.....|
Frog  1058 KLRYAISMNTGF 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	124/390 (32%)
		HECTc	1092..1423	CDD:214523	116/364 (32%)
ube3b	NP_001072875.1	IQ	28..50	CDD:197470
ube3b	NP_001072875.1	HECTc	686..1070	CDD:238033	124/389 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910