DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and itch

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001072737.1 Gene:itch / 780194 XenbaseID:XB-GENE-976485 Length:853 Species:Xenopus tropicalis


Alignment Length:1287 Identity:346/1287 - (26%)
Similarity:486/1287 - (37%) Gaps:513/1287 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 RKSWTLSPQSGGSTPLSGAKKKT----KTGAP---------TTTLSNANGDGFNLWVARECFETV 238
            ||:| ..|.......:.|..|||    ||.:|         .|..|..|   |.:|         
 Frog    33 RKNW-FGPSPYVELSVDGQSKKTETKNKTHSPKWKQPLTVIVTPFSVLN---FRVW--------- 84

  Fly   239 PAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHR 303
                                 ..:....::|:|:|:.                 :|.:.....:.
 Frog    85 ---------------------SHQTLKSDALIGSASL-----------------NLHETLLSNNM 111

  Fly   304 PLERSWPPRAVGRDLKLQGDV-FQFDILDTD-ERLAE-EMAQGSGSSNNSPLATPPVRFKPLLKK 365
            .||.......:..|.:..||: ...|.:..| |.||. :.|..|||::||               
 Frog   112 KLEEVIVTMQLLSDRETVGDLSVCLDGMQVDPELLANGDPAVSSGSTDNS--------------- 161

  Fly   366 KIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSS-SPNSLQFPYLRQHRPLTRALSNGKAS 429
                       ||:......|.|     ||:...|:.| :.|.:..|          :|:||...
 Frog   162 -----------STEVESQAASAE-----SSNGTNSTDSRTTNGMSSP----------SLANGGFK 200

  Fly   430 SSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFH 494
            :|.          |.||..||                  ..:|.|..||..|:.:|.||      
 Frog   201 ASR----------PPRPSRPP------------------PPTPRRASGVVTAISEAPPP------ 231

  Fly   495 GQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPP 559
               |:..||                       |||              |.:||....| ||..|
 Frog   232 ---PEAELL-----------------------PTP--------------ATASLPEAQA-PSSTP 255

  Fly   560 AVSSQLDYIYLQDG-------------GQEQGQEQSDEVV---HISSTRLPSIPERSAAAAAAAA 608
            .||.|:..|.: ||             |.||..:|...|.   |::.......||          
 Frog   256 PVSRQIAPINV-DGQRMGLVNQGPLPPGWEQRVDQQGRVYYVDHVAKRTTWDRPE---------- 309

  Fly   609 AAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSG 673
                                        ||||.||.|:|:.|||:|:||.||||:||||      
 Frog   310 ----------------------------PLPPGWERRVDNMGRIYYVDHITRTTTWQRP------ 340

  Fly   674 GPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILML 738
                           ..:|:|.....:.:..||                                
 Frog   341 ---------------TLESVRNYEQWQLQRNQL-------------------------------- 358

  Fly   739 CRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRE---- 799
                        :.|:..:|                   ||:.|...     .|....::|    
 Frog   359 ------------QGAMQQFN-------------------QRFIYGTQ-----ETGTTQNKEYDPL 387

  Fly   800 --LPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDG 862
              ||..||.::|.:|:.:|::|..|.|.:.|||                                
 Frog   388 GPLPVGWEKRMDGNGRVYFVNHTTRTTQWEDPR-------------------------------- 420

  Fly   863 NCLSATSGHINASPAS-------SVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNA 920
                 ..|.:|..|..       :|.|:|                 :...||..||:.|      
 Frog   421 -----NQGQLNEKPLPEGWEMRFTVDGIP-----------------YFVDHNRKTTTYI------ 457

  Fly   921 DRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILR 985
                                                .|.                          
 Frog   458 ------------------------------------DPR-------------------------- 460

  Fly   986 VEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLR 1050
             .|..||:...|               :.:|                          |||:||::
 Frog   461 -TGKSALDNGPH---------------IAYV--------------------------RDFKAKVQ 483

  Fly  1051 SFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSR 1115
             ::|....:.|  .|..:|:.:.|..|.||:|::|||.|.:||:| ||.::...||||||||.:|
 Frog   484 -YFRFWCQQLY--MPQHVKITVNRKTLFEDSFQQIMSFNAQDLRR-RLWIIIPGEEGLDYGGVAR 544

  Fly  1116 EFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLLDAF 1179
            |:|||||.|:.||.|.||||:..|.|.:|::|.| :::..| .:|||.||.:.:||.|...:|..
 Frog   545 EWFFLLSHEVMNPMYCLFEYAGKDNYCLQINPAS-YINPDHLRYFRFIGRFIAMALFHGKFIDTG 608

  Fly  1180 FTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKP 1244
            |:.||||.:|..||.|.||||:|.||:.||.||:||:| ....|.:.|.|.:|:||.|...:|||
 Frog   609 FSLPFYKRILNKPVGLKDLESVDPEFYNSLIWIKDNNI-EECGLEMFFSVDKEILGDVKSHDLKP 672

  Fly  1245 GGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAE 1309
            .|.||.:.|:||:||:..:.:|||.|||:|||::...||.|::..:.:..|||:|||:::.|..|
 Frog   673 DGSNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQE 737

  Fly  1310 IDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGP 1374
            ||.|||:.||.||. |....:.|:||||.::...||:|:|||||||||..:|..||:.|.||.||
 Frog   738 IDLNDWQRNTIYRH-YTRTSKQIIWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGP 801

  Fly  1375 RRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            ::|||||.||.|.|||:||||||||||||.:.|.|.||||.|:|||..||.|
 Frog   802 QKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 19/28 (68%)
HECTc 1068..1424 CDD:238033 182/356 (51%)
HECTc 1092..1423 CDD:214523 172/331 (52%)
itchNP_001072737.1 C2_E3_ubiquitin_ligase 17..137 CDD:175988 25/154 (16%)
WW 279..308 CDD:306827 6/28 (21%)
HUL4 <310..853 CDD:227354 255/802 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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