Protein Alignment Hecw and ube3c

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001072518.1
• Gene: ube3c / 779973
• XenbaseID: XB-GENE-1011935
• Length: 1082
• Species: Xenopus tropicalis
• Alignment Length: 534
• Identity: 157/534 - (29%)
• Similarity: 252/534 - (47%)
• Gaps: 64/534 - (11%)

  Fly   922 RSAYGAAGMASAGATAAGYEDVPIAYNEK--VIAFLRQPNILEILRERQGQ-------HTMSRQL 977
            |..|.|| ..|.|.|........|...:|  :..|....|::::|:.|..:       |.:|.|.
 Frog   568 REEYMAA-FRSIGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQE 631

  Fly   978 REKINILRVEGVPA------LERLGH--DLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMP 1034
            ..|.:.:....||:      :.|:|.  .||.|:.:.|                :.:|:..|...
 Frog   632 NIKADKVTQLYVPSARHVWRVRRMGRIGPLQSTLDVGL----------------EPAPLSVSEER 680

  Fly  1035 QRA---PPPFRRDFEAKLRSFYR-----KLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKK 1091
            |.|   ..||...||.:::.|.|     |.|.:|.|.....:.:.|||:::.|||:.::...|:.
 Frog   681 QLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDAYDKLSPENEP 745

  Fly  1092 DLQRGRLAVLWDT----EEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFV 1152
            ||::.....|.:|    |.|:|.||..|||...|.:..|||..|.|: :.|:. .:..:|.:..:
 Frog   746 DLKKRIRVHLLNTHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK-TTNEG-LLYPNPAAQML 808

  Fly  1153 --DNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALL--RLPVALSDLESLDNEFHQSLQWIR 1213
              |:....:.|.||:||.||....|::..|...|...||  ...|.:..|.|||.|.:::|.:::
 Frog   809 VGDSFARHYYFLGRMLGKALYENMLVELPFASFFLSKLLGTSADVDIHHLASLDPEMYRNLLFLK 873

  Fly  1214 --DNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQT 1276
              ::|:   .:|||.|.|....||.....|||.|||:|.:...|:..|:..:..:||.:.::...
 Frog   874 SYEDDV---EELGLNFTVVNNDLGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHC 935

  Fly  1277 ESLVRGFYEVIDSRLVSVFDARELELVIAGT-AEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIE 1340
            .:..:|...|::...:.:||.:||:::|:|. ..|..:|.:..|.|..||..:|.||..||:|:|
 Frog   936 LAFRQGLANVVNLEWLRMFDQQELQVLISGAQVPICLDDLKSFTNYSGGYSADHAVIKIFWRVVE 1000

  Fly  1341 RFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKP-NALPRAHTCFNRLDLPPYP 1404
            .|::|::.:||:|||..|..|..||..|..:     |||...|.. ..||.|.||.|.|.||.:.
 Frog  1001 NFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFY 1060

  Fly  1405 TPELLYEKLLLAVE 1418
            ...|:..|||.|:|
 Frog  1061 DEHLMKSKLLYAIE 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800
		HECW1_helix	738..794	CDD:465766
		HECTc	1068..1424	CDD:238033	118/363 (33%)
ube3c	NP_001072518.1	IQ	47..64	CDD:197470
		HECTc	724..1080	CDD:238033	118/361 (33%)