Protein Alignment Hecw and Smurf1

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_006504947.1
• Gene: Smurf1 / 75788
• MGIID: 1923038
• Length: 757
• Species: Mus musculus
• Alignment Length: 917
• Identity: 254/917 - (27%)
• Similarity: 359/917 - (39%)
• Gaps: 327/917 - (35%)

  Fly   555 PSDPPAVSSQLDYIYLQ------DGGQE---QGQEQSDEVVHISS---TRLPSIPERSAAAAAAA 607
            |||..||..|: .:.||      .||..   :|..:::..|:..|   ..|..:.|..|......
Mouse   123 PSDTDAVRGQI-VVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGT 186

  Fly   608 AAAAAGA-----------------ALMEPGTGTVSG-----SSGAGAAGEPPLPPAWEARMDSHG 650
            .|||.|.                 .|..|   .|.|     .:.......|.||..:|.|....|
Mouse   187 GAAAGGGNCRFVESPSQDQRLLVQRLRNP---EVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQG 248

  Fly   651 RIFYIDHTTRTTSWQRP------GAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNL 709
            :::::...|..::|..|      |..|.|..|           ..|:.:.:..|:|
Mouse   249 QVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEA-----------FLYEFLLQGHTSE--------- 293

  Fly   710 PTSANS-NANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRD 773
            |...|| |.:...|
Mouse   294 PRDLNSVNCDELGP--------------------------------------------------- 307

  Fly   774 PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRV 838
                                      ||..||.:...||:.:|:||.:|.|.|.||||
Mouse   308 --------------------------LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL------- 339

  Fly   839 VRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHG 903
             .|...|..|...                                |..|...||..|...
Mouse   340 -HHIMNHQCQLKE--------------------------------PSQPLQLPSEGSVED----- 366

  Fly   904 HGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQ 968
                                                 |::|....|
Mouse   367 -------------------------------------EELPAQRYE------------------- 375

  Fly   969 GQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRM 1033
                  |.|.:|:.:||           |:|.|                   :.||..
Mouse   376 ------RDLVQKLKVLR-----------HELSL-------------------QQPQAG------- 397

  Fly  1034 PQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRL 1098
                                             ..::.:.|..:.|:::|:||....|||:: ||
Mouse   398 ---------------------------------HCRIEVSREEIFEESYRQIMKMRPKDLKK-RL 428

  Fly  1099 AVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSG 1163
            .|.:..||||||||.:||:.:||..|:.|||||||:||.::.||:|::|.|:...:...:|.|.|
Mouse   429 MVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVG 493

  Fly  1164 RVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFC 1228
            |::|||:.|.:.::..||.||||.||..|:.||||||:|.|.|:||.||.:|||...:|  .|||
Mouse   494 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLD--HTFC 556

  Fly  1229 VTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVS 1293
            |.....|.::..||||.|:|:.:.|:|||||:...:.||..||::.|..:|.:||.|:|...|:.
Mouse   557 VEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK 621

  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358
            .||.:||||:|.|..:||.|||:.||..:....|:: ::.||||.:|.|..|:|.||||||||::
Mouse   622 PFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685

  Fly  1359 SIPYEGFSALRGST---GPRRFCIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            .:|.:||.||:|||   |||.|.|... ...:.||:|||||||:|:|||.:.|.||||||.||||
Mouse   686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 750

  Fly  1420 TNTFGIE 1426
            |..|.:|
Mouse   751 TCGFAVE 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	4/6 (67%)
		WW	638..667	CDD:459800	7/28 (25%)
		HECW1_helix	738..794	CDD:465766	0/55 (0%)
		HECTc	1068..1424	CDD:238033	170/359 (47%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	6/15 (40%)
		WW	236..267	CDD:197736	8/30 (27%)
		WW	307..339	CDD:197736	15/108 (14%)
		HECTc	399..754	CDD:238033	170/358 (47%)