DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Smurf1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	917	Identity:	254/917 - (27%)
Similarity:	359/917 - (39%)	Gaps:	327/917 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 PSDPPAVSSQLDYIYLQ------DGGQE---QGQEQSDEVVHISS---TRLPSIPERSAAAAAAA 607
            |||..||..|: .:.||      .||..   :|..:::..|:..|   ..|..:.|..|......
Mouse   123 PSDTDAVRGQI-VVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGT 186

  Fly   608 AAAAAGA-----------------ALMEPGTGTVSG-----SSGAGAAGEPPLPPAWEARMDSHG 650
            .|||.|.                 .|..|   .|.|     .:.......|.||..:|.|....|
Mouse   187 GAAAGGGNCRFVESPSQDQRLLVQRLRNP---EVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQG 248

  Fly   651 RIFYIDHTTRTTSWQRP------GAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNL 709
            :::::...|..::|..|      |..|.|..|           ..|:.:.:..|:|
Mouse   249 QVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEA-----------FLYEFLLQGHTSE--------- 293

  Fly   710 PTSANS-NANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRD 773
            |...|| |.:...|
Mouse   294 PRDLNSVNCDELGP--------------------------------------------------- 307

  Fly   774 PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRV 838
                                      ||..||.:...||:.:|:||.:|.|.|.||||
Mouse   308 --------------------------LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL------- 339

  Fly   839 VRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHG 903
             .|...|..|...                                |..|...||..|...
Mouse   340 -HHIMNHQCQLKE--------------------------------PSQPLQLPSEGSVED----- 366

  Fly   904 HGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQ 968
                                                 |::|....|
Mouse   367 -------------------------------------EELPAQRYE------------------- 375

  Fly   969 GQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRM 1033
                  |.|.:|:.:||           |:|.|                   :.||..
Mouse   376 ------RDLVQKLKVLR-----------HELSL-------------------QQPQAG------- 397

  Fly  1034 PQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRL 1098
                                             ..::.:.|..:.|:::|:||....|||:: ||
Mouse   398 ---------------------------------HCRIEVSREEIFEESYRQIMKMRPKDLKK-RL 428

  Fly  1099 AVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSG 1163
            .|.:..||||||||.:||:.:||..|:.|||||||:||.::.||:|::|.|:...:...:|.|.|
Mouse   429 MVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVG 493

  Fly  1164 RVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFC 1228
            |::|||:.|.:.::..||.||||.||..|:.||||||:|.|.|:||.||.:|||...:|  .|||
Mouse   494 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLD--HTFC 556

  Fly  1229 VTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVS 1293
            |.....|.::..||||.|:|:.:.|:|||||:...:.||..||::.|..:|.:||.|:|...|:.
Mouse   557 VEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK 621

  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358
            .||.:||||:|.|..:||.|||:.||..:....|:: ::.||||.:|.|..|:|.||||||||::
Mouse   622 PFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685

  Fly  1359 SIPYEGFSALRGST---GPRRFCIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            .:|.:||.||:|||   |||.|.|... ...:.||:|||||||:|:|||.:.|.||||||.||||
Mouse   686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 750

  Fly  1420 TNTFGIE 1426
            |..|.:|
Mouse   751 TCGFAVE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/28 (25%)
		HECTc	1068..1424	CDD:238033	170/359 (47%)
		HECTc	1092..1423	CDD:214523	164/334 (49%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	6/15 (40%)
		WW	236..267	CDD:197736	8/30 (27%)
		WW	307..339	CDD:197736	15/108 (14%)
		HECTc	399..754	CDD:238033	170/358 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810