Protein Alignment Hecw and Herc3

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_082981.3
• Gene: Herc3 / 73998
• MGIID: 1921248
• Length: 1050
• Species: Mus musculus
• Alignment Length: 1054
• Identity: 238/1054 - (22%)
• Similarity: 391/1054 - (37%)
• Gaps: 250/1054 - (23%)

  Fly   509 GAGA-GATGGATGSPLVCPPTPTHHARRHARLQAVTAN---SSLASGGAIPSDPPAVSSQLDYIY 569
            |||: |..|..|....|..|.......:...||....|   .:||:.|...:.......||..
Mouse   109 GAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGL-- 171

  Fly   570 LQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAG 634
                |:|...:.|.:.|.    .|..||     .|..||..|...||...|.....|.:.||..|
Mouse   172 ----GKEFPSQTSPQRVR----SLEGIP-----LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223

  Fly   635 -------EPPLPPAWEARMDSHGRIFYI----DHTTRTTSWQRPG-----AAPSGGPAGREQHHR 683
                   |.|.    ..::....::.||    :||...|   :.|     .|.|.|..|.:..:.
Mouse   224 LSDEKDRESPC----HVKLLRTQKVVYISCGEEHTAVLT---KSGGVFTFGAGSCGQLGHDSVND 281

  Fly   684 QQLDRRYQSIRRTITNESRAAQLYNL---PTS---------------ANSNANSTAPAAPPPATA 730
            :...||...:..:...:....:.:.|   |:|               .....|...|:......|
Mouse   282 EVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCNVKCPSPVKGHWA 346

  Fly   731 IHPAIL-----------------------MLCRP--------DFYSLLHT------NEAALAIYN 758
            .|.:.|                       :||..        ||.::..|      |:..:|::.
Mouse   347 AHSSQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAVDFRTVNQTHYTNLINDETIAVWR 411

  Fly   759 RNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPS--CW-----ETKLDQSGKQFF 816
            :...                  ::|.     .||...:.:.|.|  ||     |.|:|
Mouse   412 QKLT------------------EHNN-----ANTVNGVVQILSSAACWNGSFLEKKID------- 446

  Fly   817 IDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVS 881
               :|.:||...|.:.:...|::..:..|||...             .|........:.....:|
Mouse   447 ---EHFKTSPKIPGIDLNSTRILFEKLMHSQHSM-------------ILEQILNSFESCLIPQLS 495

  Fly   882 GVPP---------LPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATA 937
            ..||         :.|..|....|          ....|..|..|:...|.....:.:.....:.
Mouse   496 SSPPDVEAMRIYLILPEFPLLQDS----------KYYITLTIPLAMAILRLETNPSKVLDNWWSQ 550

  Fly   938 AGYEDVPIAYNEKVIAFLRQPNILEILRERQ---------GQHTMSRQLREKINILRVEGVPALE 993
            |    .| .|..|::. |.:..:|.:||.|:         ...|.:.:|.||:..:.::    ::
Mouse   551 A----CP-KYFMKLVT-LYKGAVLYLLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLK----VK 605

  Fly   994 RLGHDL----QLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYR 1054
            .:.:|.    :::.|:.:.|..:|.|  :.:...:..|.:..........||..|.:||.:....
Mouse   606 HVEYDKFYIPEISSLVDIQEDYLMWF--LHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQT 668

  Fly  1055 KLESKG---------------------YGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRL 1098
            ..|.:.                     ..:.|. |.||:||:||:.||.|.:...:..||:: .|
Mouse   669 DAELQMQVAVNGANLQNVFMLLTLEPLLARSPF-LVLHVRRNHLVGDALRELSIHSDIDLKK-PL 731

  Fly  1099 AVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNC---HDWFR 1160
            .|::|.|||:|.||.::|||.||.:||.||.||:|.|       .|.|.|..|.|.|   |:||.
Mouse   732 KVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTY-------YQDSNLLWFSDTCFVEHNWFH 789

  Fly  1161 FSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGL 1225
            ..|...|||:.:..::|..|....||.||.:..:|.||:.|.....:|||.:.|.   .|.|:..
Mouse   790 LIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDY---PGEDIEE 851

  Fly  1226 TFC----VTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEV 1286
            |||    |..|..|.:..::|.|||..:.:.:.|::|:::..:.:..:..|.|...:...||.:|
Mouse   852 TFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKV 916

  Fly  1287 IDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLL 1351
            ...:::.:|...||..::.|.:..|..:......||..|...|..:..||:....|..|::.:.|
Mouse   917 CGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFL 981

  Fly  1352 QFVTGTSSIPYEGFSALR-----GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYE 1411
            .|:||:..||..|.::|:     .:||      |::     ||.||||:|.||||.|.:.|::..
Mouse   982 LFLTGSDRIPIYGMASLQIIIQSTATG------EEY-----LPVAHTCYNLLDLPKYSSKEIMKA 1035

  Fly  1412 KLLLAVEETNTFGI 1425
            :|..|::....|.:
Mouse  1036 RLTQALDNYEGFSL 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	14/56 (25%)
		WW	638..667	CDD:459800	5/32 (16%)
		HECW1_helix	738..794	CDD:465766	10/69 (14%)
		HECTc	1068..1424	CDD:238033	119/367 (32%)
Herc3	NP_082981.3	ATS1	3..341	CDD:444065	53/253 (21%)
		RCC1	313..377	CDD:395335	6/63 (10%)
		HECTc	702..1048	CDD:238033	119/367 (32%)