DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Ubr5

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	1493	Identity:	294/1493 - (19%)
Similarity:	464/1493 - (31%)	Gaps:	537/1493 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LAEEMAQGSGSSNN---SPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSA 397
            |:.||| .|...||   .|:......|:.||...:  :...|...:..|||......||.|.:.|
Mouse  1439 LSVEMA-SSKKKNNFIPQPIGKCKRVFQALLPYAV--EELCNVAESLIVPVRMGIARPTAPFTLA 1500

  Fly   398 VGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLD 462
            ..|..:...|.:   |....||....|:.:||||.:..|..::.:|::.|
Mouse  1501 STSIDAMQGSEE---LFSVEPLPPRPSSDQASSSSQSQSSYIIRNPQQRR--------------- 1547

  Fly   463 ISLSPEQHSPTRGR-------------------GVGGALQDAVPPGTPTFHGQRPQQRLLKRVGG 508
            ||    |..|.|||                   ||.|. :|        .|.::.:.       |
Mouse  1548 IS----QSQPVRGRDEEQDDIVSADVEEVEVVEGVAGE-ED--------HHDEQEEH-------G 1592

  Fly   509 GAGAGATG-----GATGSP-----LVCPPTPTHHARRHA-------RLQAVTANSSLASGGA--I 554
            ...|.|.|     ...||.     |....|.:.....|:       |...|||.::.:..||  :
Mouse  1593 EENAEAEGHHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSV 1657

  Fly   555 P-------------SDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHIS-STRLPSI-------PE 598
            |             ||..:.|||.|.|..:....::..|::....|.: :.:.|..       |:
Mouse  1658 PAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNPQ 1722

  Fly   599 RSAAAAAA------AAAAAAGAALMEPG----TGTVSGSSGAGAAG------------------- 634
            ...||:.|      .||::||...::|.    :||:|.|:.|.||.
Mouse  1723 HQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARA 1787

  Fly   635 --------------------------------------------EPPLPPAWE---ARMDSHGRI 652
                                                        |..|.|.|.   :.|||
Mouse  1788 YSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSVMDS---- 1848

  Fly   653 FYIDHTTRTTSWQRPGAA-PSGGPAGREQH---------HRQQLDRRYQSIRRTITNESRAAQL- 706
                    |.:..|.|:| .|.|..|...|         .|:::..|.::..||:....||..|
Mouse  1849 --------TEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLS 1905

  Fly   707 ----------------YNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALA 755
                            .:|..|.|...:...|            :|.:|     ||.|......|
Mouse  1906 ARQGMMSARGDFLNYALSLMRSHNDEHSDVLP------------VLDVC-----SLKHVAYVFQA 1953

  Fly   756 -IYNRNAALKHMVMRIRRDPPCFQRYQYNKDL-VALVNTFAQMSRELPSCWETKLD--------- 809
             ||    .:|.|..:...|.|..:|.:..:.| :.:.|..::...:..:.....|:
Mouse  1954 LIY----WIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDDSLPA 2014

  Fly   810 QSGKQ--FFIDHQHRRTSFMD-----PRLPVECP---RVVRHRQQHSQQ----------QSSVGY 854
            ::|:.  ||     ||:..|.     |..|.|.|   .:....|.|..|          :.|.|.
Mouse  2015 ETGQNHPFF-----RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGL 2074

  Fly   855 YYPD----------LVDGNCLSATSGHI-------------------------------NASPAS 878
            |...          .:|.|||......:                               ::.|..
Mouse  2075 YSSSAGSGKCIVEVTMDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQSLLAEEADSSKPGP 2139

  Fly   879 SVSGV-------------------PPLPPPRPSSS------------------------------ 894
            |...|                   |||...||..|
Mouse  2140 SAPDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDV 2204

  Fly   895 --------------------------------------------------SSSSRSSHGH-GHNC 908
                                                              ..:.|..:.| |..|
Mouse  2205 GAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVKVDRDRDLLIQQTMRQLNNHFGRRC 2269

  Fly   909 NTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAY--NEKVIAFLRQPNILEILRERQGQH 971
            .||   ..|::..:..:.......:|...:.|..:..|:  |||:      ||:..|....:|.|
Mouse  2270 ATT---PMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL------PNLDCIQNANKGTH 2325

  Fly   972 T-----------MSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQG 1025
            |           ..|:...:..:.|..|:.|..|...|......||:   :...|.|..|.:|..
Mouse  2326 TSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSI---DTRPFRPASEGNPSD 2387

  Fly  1026 SP--------VLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAF 1082
            .|        .|..|:..|.        :|...:|..|:........|.:|.|.:..    ||:.
Mouse  2388 DPDPLPAHRQALGERLYPRV--------QAMQPAFASKITGMLLELSPAQLLLLLAS----EDSL 2440

  Fly  1083 R-RIMSANKKDLQRGR---------LAVLWDTE--------------------EGLDYGGPSREF 1117
            | |:..|.:..:..||         |.:|..:|                    |..|.|..:...
Mouse  2441 RARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLEDTDDGDDNAPL 2505

  Fly  1118 FFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTR 1182
            |:...:..|              ||.:....:....||   ||..||:|||.|:...|......|
Mouse  2506 FYQPGKRGF--------------YTPRPGKNTEARLNC---FRNIGRILGLCLLQNELCPITLNR 2553

  Fly  1183 PFYKALLRLPVALSDLESLDNEFHQSLQWI------RDND-IGTGVDLGLTFCVTEELLGSVVDR 1240
            ...|.||...|...|....|...::||:.:      .|.| :.:.:||.....:.:|..|..|
Mouse  2554 HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-- 2616

  Fly  1241 ELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIA 1305
            ||.|.|.||.:..:|..||:.:..:.|:....::...::.:|..:|:....:....|.:..|::.
Mouse  2617 ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVN 2681

  Fly  1306 GTAEIDTNDWRLNTEYRSGYHDNHQVIV----WFWQVIERFSNEQRLRLLQFVTGTSSIP--YEG 1364
            |..|::.......|.:.....:|.:.::    |||.::|:.|..:|..|:.|.|.:.|:|  .||
Mouse  2682 GCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEG 2746

  Fly  1365 FSALRGSTGPRRFCIEKWGKP---NALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFG 1424
            |..:...|          .:|   ..||.|:||.:||.:|.|.:.::|.:|||||: :|..||
Mouse  2747 FQPMPSIT----------IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/31 (23%)
		HECTc	1068..1424	CDD:238033	96/401 (24%)
		HECTc	1092..1423	CDD:214523	89/375 (24%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	14/74 (19%)
		HECTc	2469..2797	CDD:214523	86/357 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900