DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Arel1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001351118.1	Gene:	Arel1 / 68497	MGIID:	1915747	Length:	823	Species:	Mus musculus

Alignment Length:	391	Identity:	123/391 - (31%)
Similarity:	206/391 - (52%)	Gaps:	30/391 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 FEAKLRSFYRKLESKGYGQGPH-KLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGL 1108
            |:.|:..|.|:|. :.:.:.|| |:.|.:.|..|||.:.:...:.:..|..: ...|::..||.|
Mouse   439 FQDKVNFFQRELR-QVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVVFQDEEAL 501

  Fly  1109 DYGGPSREFFFLLSRELFNPYYGLF-EYSANDTYTVQVSPLSAFVDNCH---DWFRFSGRVLGLA 1169
            |:|||.||:|.|:.:.||:....|| .::.::...|..:|...    .|   ..:.|:||::|..
Mouse   502 DWGGPRREWFELICKALFDTTSQLFARFTDSNQALVHPNPNRP----AHLRLKMYEFAGRLVGKC 562

  Fly  1170 L-------VHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS-LQWIRDNDIGTGVDLGLT 1226
            |       .::.|:.|.|||.|...::.|.:.....|:.|.||::| :.:|.:||:.   ::.|.
Mouse   563 LYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMS---EMELV 624

  Fly  1227 FCVTEELLGSVVDR--ELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDS 1289
            |...:......:|:  ||..||....:...||..||..:.::||...|:|:.|..::|..|::..
Mouse   625 FAEEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPE 689

  Fly  1290 RLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSG-YHDNHQVIVWFWQVIERFSNEQRLRLLQF 1353
            .|:::||..||||::.||.:|:.:|::.:.....| :|...:|:.|||.|:...:.|:..|||||
Mouse   690 NLLAIFDENELELLMCGTGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQEELARLLQF 754

  Fly  1354 VTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVE 1418
            .||:|.:|..||:||..|     |.|......:.||.||||||:|.||.|.:.|.::..|.||:.
Mouse   755 TTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814

  Fly  1419 E 1419
            |
Mouse   815 E 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	115/367 (31%)
		HECTc	1092..1423	CDD:214523	110/343 (32%)
Arel1	NP_001351118.1	Filamin	56..154	CDD:395505
		Filamin	64..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345
		HECTc	464..821	CDD:238033	115/365 (32%)
		Interaction with SOCS2. /evidence=ECO:0000250\|UniProtKB:O15033	483..789		96/318 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900