DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Wwp2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	1202	Identity:	319/1202 - (26%)
Similarity:	454/1202 - (37%)	Gaps:	371/1202 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 AAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQH-------RPLERSWPPRAVGRDLKL 320
            |:|..|..|.|...:.|....:....:...|.|||....:       .|.|.....:.:|....|
Mouse     2 ASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELL 66

  Fly   321 QGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIG----PDSYINTISTQKV 381
            ..::...::  |.:...:.......:..|..|.|..|....:||...|    ....:|..:..|.
Mouse    67 WNEIIVLNV--TAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKG 129

  Fly   382 PVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRP 446
            .|....|...|.....|...|                    :.||.|.:...|
Mouse   130 SVVSGGELTIFLDGPTVDLGS--------------------VPNGSAVTDGSQ------------ 162

  Fly   447 RSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAG 511
              |||..|:.:|      ::||    ||.:          ||.|..|.|:....    |..||:.
Mouse   163 --PPSRESSGTA------IAPE----TRHQ----------PPSTNCFGGRSRTH----RHSGGSA 201

  Fly   512 AGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQE 576
            ..||..:..||         .||...|.....::||..:.|.:..:|...|.
Mouse   202 RTATAASEQSP---------GARNRHRQPVKNSSSSGLANGTVNEEPTPASE------------- 244

  Fly   577 QGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGT--------------GTVSGS 627
                                ||.|:.....:..|||.:....|.|              .:.||:
Mouse   245 --------------------PEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGT 289

  Fly   628 SGAGAAGEPP--LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRY 690
            ....||.:.|  ||..||.|...:||::|:||.|:||:|:||
Mouse   290 QQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----------------------- 331

  Fly   691 QSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALA 755

Mouse   332 ----------------------------------------------------------------- 331

  Fly   756 IYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQ 820
                                                        ||..||.:.|..|:.:::||.
Mouse   332 --------------------------------------------LPPGWEKRTDPRGRFYYVDHN 352

  Fly   821 HRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHIN-----ASPASSV 880
            .|.|::..|     ....||:.:|...|:             |.|.....|.:     .|.::|.
Mouse   353 TRTTTWQRP-----TAEYVRNYEQWQSQR-------------NQLQGAMQHFSQRFLYQSSSAST 399

  Fly   881 SGVP--PLPPPRPSSSSSSSRSSHGH----GHNCNTTSAISCALNADRSAYGAAGMASAGATAAG 939
            ...|  ||||      ....|..:|.    .||..||.     ....|:    .||....|...|
Mouse   400 DHDPLGPLPP------GWEKRQDNGRVYYVNHNTRTTQ-----WEDPRT----QGMIQEPALPPG 449

  Fly   940 YEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTIL 1004
            :|   :.|..:.:.:.                                       :.|:.:.|
Mouse   450 WE---MKYTSEGVRYF---------------------------------------VDHNTRTT-- 470

  Fly  1005 LSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLK 1069
              .|:....||   |..:.|||           |..:.|.|..|...|.....|...   |..:|
Mouse   471 --TFKDPRPGF---ESGTKQGS-----------PGAYDRSFRWKYHQFRFLCHSNAL---PSHVK 516

  Fly  1070 LHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFE 1134
            :.:.|..|.||:|::||:....||:| ||.::...||||||||.:||:|||||.|:.||.|.|||
Mouse   517 ISVSRQTLFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFE 580

  Fly  1135 YSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLE 1199
            |:..:.|.:|::|.|:...:...:|||.||.:.:||.|...:|..||.||||.:|.....|.|||
Mouse   581 YAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLE 645

  Fly  1200 SLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMI 1264
            |:|.||:.|:.||::|:: ....|.|.|....|:||.|...|||.||:||.:.|:||:||:..:.
Mouse   646 SIDPEFYNSIVWIKENNL-EECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLT 709

  Fly  1265 KWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNH 1329
            .||..|||:|||::.:.||.||.....:..||.:||||::.|..|||.:||:.|..||. |..:.
Mouse   710 DWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH-YTKSS 773

  Fly  1330 QVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTC 1394
            :.|.|||||::...||:|:|||||||||..:|..||:.|.||.||::|||::.||...|||:|||
Mouse   774 KQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTC 838

  Fly  1395 FNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||||||||.:.|.|.||||.|:|||..||.|
Mouse   839 FNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	14/28 (50%)
		HECTc	1068..1424	CDD:238033	171/355 (48%)
		HECTc	1092..1423	CDD:214523	163/330 (49%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	22/126 (17%)
		PRK07003	<149..>299	CDD:235906	46/249 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		46/249 (18%)
		WW	302..331	CDD:366073	14/28 (50%)
		WW	332..361	CDD:366073	10/28 (36%)
		WW	407..435	CDD:366073	9/38 (24%)
		WW	447..477	CDD:238122	6/75 (8%)
		HECTc	516..868	CDD:238033	171/354 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810