DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and SMURF2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens

Alignment Length:	820	Identity:	253/820 - (30%)
Similarity:	350/820 - (42%)	Gaps:	261/820 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTIT---N 699
            ||..||.|..:.|||.|::|.||||.|:||....|                .|.|..|.::   :
Human   159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS----------------EYSSPGRPLSCFVD 207

  Fly   700 ESRAAQLYNLPTSANSNANSTAPAAPPPA---------------TAIH-PAILMLCRPDFYS--- 745
            |       |.|.|..:.|.....:.|..|               |.:| |..|    |:.|.
Human   208 E-------NTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDL----PEGYEQRT 261

  Fly   746 -------LLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSC 803
                   .|||.......::         .|:.||               |.|...:....||..
Human   262 TQQGQVYFLHTQTGVSTWHD---------PRVPRD---------------LSNINCEELGPLPPG 302

  Fly   804 WETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVV-RHRQQHSQQQSSVGYYYPDLVDGNCLSA 867
            ||.:...:|:.:|:||.:|.|.|.||||......|: |..|...|||..|....||  |..||:.
Human   303 WEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPD--DTECLTV 365

  Fly   868 TSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMAS 932
                                 ||
Human   366 ---------------------PR------------------------------------------ 367

  Fly   933 AGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGH 997
                                                    ..|.|.:|:.|||.|
Human   368 ----------------------------------------YKRDLVQKLKILRQE---------- 382

  Fly   998 DLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYG 1062
                                           |:.:.||..
Human   383 -------------------------------LSQQQPQAG------------------------- 391

  Fly  1063 QGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFN 1127
                ..::.:.|..:.|:::|::|....|||.: ||.:.:..||||||||.:||:.:|||.|:.|
Human   392 ----HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLN 451

  Fly  1128 PYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLP 1192
            ||||||:||.:|.||:|::|.||.......:|.|.||::|:|:.|.:.:|..||.||||.||...
Human   452 PYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516

  Fly  1193 VALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKK 1257
            :.|.|:|.:|.:.|.||.||.:||| ||| |..||||.....|.::..||||.||:|.:||:|||
Human   517 ITLDDMELVDPDLHNSLVWILENDI-TGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKK 579

  Fly  1258 EYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYR 1322
            ||:...:.||..||::.|..:|.:||.|||...|:..||.:||||:|.|..:||.|||::||..:
Human   580 EYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLK 644

  Fly  1323 SGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGK-PN 1386
            ....|:: ::.|||:.:|.|..|:|.||||||||:|.:|.:||.||:|:.|||.|.|.:... .|
Human   645 HCTPDSN-IVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTN 708

  Fly  1387 ALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .||:|||||||:|:|||.:.|.||||||.|:|||..|.:|
Human   709 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	15/28 (54%)
		HECTc	1068..1424	CDD:238033	170/356 (48%)
		HECTc	1092..1423	CDD:214523	165/331 (50%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	251/815 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810