Protein Alignment Hecw and SMURF2

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_047292502.1
• Gene: SMURF2 / 64750
• HGNCID: 16809
• Length: 750
• Species: Homo sapiens
• Alignment Length: 820
• Identity: 253/820 - (30%)
• Similarity: 350/820 - (42%)
• Gaps: 261/820 - (31%)

  Fly   638 LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTIT---N 699
            ||..||.|..:.|||.|::|.||||.|:||....|                .|.|..|.::   :
Human   161 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS----------------EYSSPGRPLSCFVD 209

  Fly   700 ESRAAQLYNLPTSANSNANSTAPAAPPPA---------------TAIH-PAILMLCRPDFYS--- 745
            |       |.|.|..:.|.....:.|..|               |.:| |..|    |:.|.
Human   210 E-------NTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDL----PEGYEQRT 263

  Fly   746 -------LLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSC 803
                   .|||.......::         .|:.||               |.|...:....||..
Human   264 TQQGQVYFLHTQTGVSTWHD---------PRVPRD---------------LSNINCEELGPLPPG 304

  Fly   804 WETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVV-RHRQQHSQQQSSVGYYYPDLVDGNCLSA 867
            ||.:...:|:.:|:||.:|.|.|.||||......|: |..|...|||..|....||  |..||:.
Human   305 WEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPD--DTECLTV 367

  Fly   868 TSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMAS 932
                                 ||
Human   368 ---------------------PR------------------------------------------ 369

  Fly   933 AGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGH 997
                                                    ..|.|.:|:.|||.|
Human   370 ----------------------------------------YKRDLVQKLKILRQE---------- 384

  Fly   998 DLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYG 1062
                                           |:.:.||..
Human   385 -------------------------------LSQQQPQAG------------------------- 393

  Fly  1063 QGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFN 1127
                ..::.:.|..:.|:::|::|....|||.: ||.:.:..||||||||.:||:.:|||.|:.|
Human   394 ----HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLN 453

  Fly  1128 PYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLP 1192
            ||||||:||.:|.||:|::|.||.......:|.|.||::|:|:.|.:.:|..||.||||.||...
Human   454 PYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 518

  Fly  1193 VALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKK 1257
            :.|.|:|.:|.:.|.||.||.:||| ||| |..||||.....|.::..||||.||:|.:||:|||
Human   519 ITLDDMELVDPDLHNSLVWILENDI-TGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKK 581

  Fly  1258 EYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYR 1322
            ||:...:.||..||::.|..:|.:||.|||...|:..||.:||||:|.|..:||.|||::||..:
Human   582 EYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLK 646

  Fly  1323 SGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGK-PN 1386
            ....|:: ::.|||:.:|.|..|:|.||||||||:|.:|.:||.||:|:.|||.|.|.:... .|
Human   647 HCTPDSN-IVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTN 710

  Fly  1387 ALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .||:|||||||:|:|||.:.|.||||||.|:|||..|.:|
Human   711 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800	15/28 (54%)
		HECW1_helix	738..794	CDD:465766	10/65 (15%)
		HECTc	1068..1424	CDD:238033	170/356 (48%)
SMURF2	XP_047292502.1	C2_Smurf-like	19..139	CDD:176028
		HUL4	<161..747	CDD:227354	251/815 (31%)