DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Huwe1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006528996.1	Gene:	Huwe1 / 59026	MGIID:	1926884	Length:	4456	Species:	Mus musculus

Alignment Length:	1821	Identity:	415/1821 - (22%)
Similarity:	637/1821 - (34%)	Gaps:	565/1821 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DEEEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTND------------------- 88
            |||.||..|.......|||.....:...:.:..:|:.|..:|.|||
Mouse  2762 DEELEERREKRRKQLAEEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTT 2826

  Fly    89 ---VHVSVSEVEE--------------HEPP--------LASRNQEVA----------------- 111
               .....||.:|              ..||        |.|..:|||
Mouse  2827 PSSTDAPTSESKETLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPT 2891

  Fly   112 ----EVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTK------------SC------ 154
                |.|..|.:|.    |.|:..||  |.|..|.....|.:|::            ||
Mouse  2892 RPSGEAETTQMELS----PAPTITSL--SPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAV 2950

  Fly   155 -ETPANNATLSPTNSYNGSIGSDGGSSVGGGA-------------RRKSWTLSPQSGGSTPLSGA 205
             :|||..::..||          .|||..|.|             .|:|  ..|....|.|.|..
Mouse  2951 GDTPAAGSSEQPT----------AGSSTPGDAPSVVAEVQGRPDVSRES--NQPPEDSSPPASSE 3003

  Fly   206 KKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLL 270
            ...|:..|  ..:|.|:..|    :..|...:..:|..|.|:...:.|.||          .|.|
Mouse  3004 SSSTRDSA--VAISGADSRG----ILEEPLPSTSSEEEDPLAGISLPEGVD----------PSFL 3052

  Fly   271 GAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRD---------LKLQGDVFQ 326
               |||....   ||:..|:...:|.|:  :..|...|..|..||..         |.......|
Mouse  3053 ---AALPDDI---RREVLQNQLGIRPPT--RSAPSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQ 3109

  Fly   327 FDIL--DTDERLAEEMAQGSGSS------------------------NNSPLATPP--------- 356
            .::|  ...|:...|:||.:.|.                        .:|.||..|
Mouse  3110 EEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQA 3174

  Fly   357 ------VRFKPLLKKKIGPDSYINTIST-------------------QKVPVHQSYEFPTFPSSS 396
                  .|.:.|:.:::...|..:.:|.                   .::.|.:...|....|||
Mouse  3175 LRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSS 3239

  Fly   397 AVGSSSSSPNSL-----------------------QFPYL---RQHRPL-------------TRA 422
            ....|.|:.::|                       ..|.|   |.||.|             .|:
Mouse  3240 HNRPSGSNVDTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRS 3304

  Fly   423 LSNGKASSSEEQ---ASPRLLLSPKRPRSPPSGCSTRSAS--PLDISLSPEQHSPTRGRGVGGAL 482
            |.:....|||.:   .:|:|..|.:|.:.....|::.|..  |||:....|..|..:...:..::
Mouse  3305 LLSILQRSSESELCIETPKLSTSEERGKKSSKSCASSSHENRPLDLLHKMESKSSNQLSWLSVSM 3369

  Fly   483 QDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATG--GATGSPLVCPPT-----------PTHHA- 533
            ..|:...|..|..||...|  |.....|.:|:|.  ....:|:||...           |:|..
Mouse  3370 DAALGCRTNIFQIQRSGGR--KHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQ 3432

  Fly   534 -----------RRHARLQAVTANSSLASGGAIPSDPPAVSSQLD-------------YIYLQDGG 574
                       |.....||.:..||.:|...|.:|...:..:||             .:.:..||
Mouse  3433 QRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSSGG 3497

  Fly   575 QEQGQEQSDE--------------VVHISS------TRLPS-----IPERSAAAAAAAAAAAAGA 614
            :.:....|.|              |:..||      .||.|     :||...:.....::.:..:
Mouse  3498 EGETSPHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEVQTNSSNSGSS 3562

  Fly   615 ALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIF---------------YIDHTTRTTSW 664
            ......|.|.: ::...|....|.|||....:.|...:.               ....||.||:.
Mouse  3563 TAATSNTSTTT-TTTTTATAPTPTPPAATTPVTSAPALVAATAISTITVAASTTVTTPTTATTTV 3626

  Fly   665 QRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPAT 729
            .......|..|| :.......:|  ::.:...:| |::......:.||.:.:......||
Mouse  3627 STSTTKGSKSPA-KVGEGGSGID--FKMVSSGLT-ENQLQLSVEVLTSHSCSEEGLEDAA----- 3682

  Fly   730 AIHPAILMLCRPDF------------------YSL---LHTNEAALAIYNRNAALKHMVMRIRRD 773
               ..:|.|.|.|.                  |:|   :.|..|.|..||.....:.....:..|
Mouse  3683 ---NVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPD 3744

  Fly   774 PPCFQRYQYNK---------DLVALVNTFAQMSR-------ELPSCWETKLDQSGKQFFI----- 817
            ....::.|..|         |:...|...|...|       :|||........|.::||:
Mouse  3745 GLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQV 3809

  Fly   818 -----------DHQHRRTSFMDP--------------RLPVECP---RVVRHRQQHSQQQSSVGY 854
                       :.:.::|..:..              :|..|..   ::||..|:..:||.
Mouse  3810 IIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQ---- 3870

  Fly   855 YYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALN 919
                       :|||...|.|..|......|:...:||.|:..::|           ..||
Mouse  3871 -----------AATSESSNQSETSVRREESPMDVDQPSPSAQDTQS-----------IVIS---- 3909

  Fly   920 ADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINIL 984
                                 :..|....||.    .:|..|.:|.|:.....:...|.|.:..|
Mouse  3910 ---------------------DGTPQGEKEKE----EKPPELPLLSEQLSLDELWDMLGECLKEL 3949

  Fly   985 RVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRA-----PPP---- 1040
            ..         .|| |..:|:.....|....|...||..: .||.::|..|.|     |||
Mouse  3950 EE---------SHD-QHAVLVLQPAVEAFFLVHATERESK-PPVRDTRESQLAHIKDEPPPLSPA 4003

  Fly  1041 -------------FRR------------------------------------------------- 1043
                         |.|
Mouse  4004 PLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLV 4068

  Fly  1044 ------DFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLW 1102
                  ||:.|.:.|.::||....|.....:.:|:||.|:.||::|.:...:.::: :.||.:::
Mouse  4069 DYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM-KNRLYIVF 4132

  Fly  1103 DTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLG 1167
            :.|||.|.||..||::.::|||:|||.|.||..|..|..|..::|.|....|...:|:|.||::.
Mouse  4133 EGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVA 4197

  Fly  1168 LALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGT-GVDLGLTFCVTE 1231
            .|:....||:.:|||.|||.:|...|..:|:||.|..|:|.|.::.:||:.| |.|  |||....
Mouse  4198 KAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYD--LTFSTEV 4260

  Fly  1232 ELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFD 1296
            :..|....|:|||.|.||::.|:|||||:..:.:.|:...:::|..:.:.||||:|..||:|:|.
Mouse  4261 QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFT 4325

  Fly  1297 ARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIP 1361
            .:||||:|:|...||.:|.:.||||.. |..|...|.|||:.:..|....|.:.||||||||.:|
Mouse  4326 EQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVP 4389

  Fly  1362 YEGFSALRGSTGPRRFCIEKWGK-PNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE-TNTFG 1424
            .:||:||.|..|.::|.|.:..: .:.||.||||||:||||.|.:.|.|...||||::| :..||
Mouse  4390 LQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4454

  Fly  1425 I 1425
            :
Mouse  4455 L 4455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	8/43 (19%)
		HECTc	1068..1424	CDD:238033	145/358 (41%)
		HECTc	1092..1423	CDD:214523	138/333 (41%)
Huwe1	XP_006528996.1	DUF908	92..367	CDD:399185
		DUF913	431..892	CDD:399192
		UBA_HUWE1	1395..1434	CDD:270474
		WWE	1695..1756	CDD:397111
		fibronec_FbpA	<2809..>2992	CDD:411474	37/200 (19%)
		DUF4414	3044..3071	CDD:405126	11/42 (26%)
		DUF4414	3089..3120	CDD:405126	4/30 (13%)
		HECTc	4101..4454	CDD:238033	145/356 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810