DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and HACE1

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:566 Identity:184/566 - (32%)
Similarity:285/566 - (50%) Gaps:98/566 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   881 SGVPPLPPPRPSS---SSSSSRSSHGHG------HNCNTTSAISCALNADRSAYGAAGMASA--- 933
            :.:||..||.|.|   .|:.:|.|....      .:.:....||...|...:...|..|..:   
Human   403 ASIPPFEPPGPGSYENLSTGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQM 467

  Fly   934 --GATAAGYEDVPIAYNEKVIAFL-RQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERL 995
              |.|:..:.:....::|.:..|: |.|.|:                              .:..
Human   468 PPGMTSPRFIEFVCKHDEVLKCFVNRNPKII------------------------------FDHF 502

  Fly   996 GHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKG 1060
            ...|:...|:|.|...|                       :|.|     |:.:...||..|.|  
Human   503 HFLLECPELMSRFMHII-----------------------KAQP-----FKDRCEWFYEHLHS-- 537

  Fly  1061 YGQGPHKLKLH----------IRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSR 1115
             || |....:|          :.|..:...:...:..||...|::| :||.:..|||:.. |..|
Human   538 -GQ-PDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQG-IAVRFHGEEGMGQ-GVVR 598

  Fly  1116 EFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLLDAF 1179
            |:|.:||.|:.||.|.||..||:.| |.|.:. :::|:..| ::|||:|::|||||.|:.|::.:
Human   599 EWFDILSNEIVNPDYALFTQSADGT-TFQPNS-NSYVNPDHLNYFRFAGQILGLALNHRQLVNIY 661

  Fly  1180 FTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLG--LTFCVTEELLGSVVDREL 1242
            |||.|||.:|.:||...|:.|:|.|:.::||||.||||.   |||  |||.|..::.|::.:..|
Human   662 FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDIS---DLGLELTFSVETDVFGAMEEVPL 723

  Fly  1243 KPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT 1307
            ||||.:|::.:.||.||::.:.:.|:.|.:|.|..:.::||:..|...|:.:||..||||:::|.
Human   724 KPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGM 788

  Fly  1308 AEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST 1372
            .|||.:||..||||.|||.....||.|||:|:|..:.|:|:.|||||||:|.:|:.||:.:.|.:
Human   789 PEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGS 853

  Fly  1373 GPRRFCIEKWG-KPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAV 1417
            |.:.|.|.... .||.||.:.||.|.|.||.||:.|:|.::||:|:
Human   854 GLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809
HECTc 1068..1424 CDD:238033 148/364 (41%)
HECTc 1092..1423 CDD:214523 144/330 (44%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894
ANK 1 64..93
ANK repeat 66..95 CDD:293786
ANK 92..217 CDD:238125
ANK repeat 97..128 CDD:293786
ANK 2 97..126
ANK repeat 130..161 CDD:293786
ANK 3 130..159
ANK repeat 163..194 CDD:293786
ANK 4 163..192
ANK 5 196..226
ANK repeat 196..221 CDD:293786
ANK 6 228..257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 9/29 (31%)
HECTc 554..903 CDD:238033 147/353 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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