Protein Alignment Hecw and SMURF1

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_065162.1
• Gene: SMURF1 / 57154
• HGNCID: 16807
• Length: 757
• Species: Homo sapiens
• Alignment Length: 913
• Identity: 260/913 - (28%)
• Similarity: 366/913 - (40%)
• Gaps: 319/913 - (34%)

  Fly   555 PSDPPAVSSQLDYIYLQ------DGGQE---QGQEQSDEVVHISSTRLPSIP-----ERSAAAAA 605
            |||..||..|: .:.||      .||..   :|..:::..|:..|.  |..|     |..|....
Human   123 PSDTDAVRGQI-VVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSG--PGRPLSCFMEEPAPYTD 184

  Fly   606 AAAAAAAGA-----------------ALMEPGTGTVSGS-----SGAGAAGEPPLPPAWEARMDS 648
            :..|||.|.                 .|..|   .|.||     :.......|.||..:|.|...
Human   185 STGAAAGGGNCRFVESPSQDQRLQAQRLRNP---DVRGSLQTPQNRPHGHQSPELPEGYEQRTTV 246

  Fly   649 HGRIFYIDHTTRTTSWQRPG-AAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTS 712
            .|:::::...|..::|..|. .:|||...|.:                       ||.||
Human   247 QGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGD-----------------------AAFLY----- 283

  Fly   713 ANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCF 777
                                         :|....||:|.
Human   284 -----------------------------EFLLQGHTSEP------------------------- 294

  Fly   778 QRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHR 842
                  :||.: ||  ......||..||.:...||:.:|:||.:|.|.|.||||        .|.
Human   295 ------RDLNS-VN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL--------HHI 342

  Fly   843 QQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHN 907
            ..|..|...                                |..|.|.||..|...
Human   343 MNHQCQLKE--------------------------------PSQPLPLPSEGSLED--------- 366

  Fly   908 CNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHT 972
                                             |::|....|
Human   367 ---------------------------------EELPAQRYE----------------------- 375

  Fly   973 MSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRA 1037
              |.|.:|:.:||           |:|.|                   :.||..
Human   376 --RDLVQKLKVLR-----------HELSL-------------------QQPQAG----------- 397

  Fly  1038 PPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLW 1102
                                         ..::.:.|..:.|:::|:||....|||:: ||.|.:
Human   398 -----------------------------HCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKF 432

  Fly  1103 DTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLG 1167
            ..||||||||.:||:.:||..|:.|||||||:||.::.|.:|::|.|:...:...:|.|.||::|
Human   433 RGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMG 497

  Fly  1168 LALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEE 1232
            ||:.|.:.::..||.||||.||..|:.||||||:|.|.|:||.||.:|||...:|  .||||...
Human   498 LAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLD--HTFCVEHN 560

  Fly  1233 LLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDA 1297
            ..|.::..||||.|:|:.:.|:|||||:...:.||..||::.|..:|.:||.|:|...|:..||.
Human   561 AFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ 625

  Fly  1298 RELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPY 1362
            :||||:|.|..:||.|||:.||..:....|:: ::.||||.:|.|..|:|.||||||||::.:|.
Human   626 KELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689

  Fly  1363 EGFSALRGST---GPRRFCIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF 1423
            :||.||:|||   |||.|.|... ...:.||:|||||||:|:|||.:.|.||||||.|||||..|
Human   690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754

  Fly  1424 GIE 1426
            .:|
Human   755 AVE 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	4/6 (67%)
		WW	638..667	CDD:459800	7/28 (25%)
		HECW1_helix	738..794	CDD:465766	8/55 (15%)
		HECTc	1068..1424	CDD:238033	169/359 (47%)
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028	6/15 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..237		6/46 (13%)
		WW	236..267	CDD:197736	8/30 (27%)
		WW	307..339	CDD:197736	14/31 (45%)
		HECTc	399..754	CDD:238033	169/358 (47%)