DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and SMURF1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_065162.1	Gene:	SMURF1 / 57154	HGNCID:	16807	Length:	757	Species:	Homo sapiens

Alignment Length:	913	Identity:	260/913 - (28%)
Similarity:	366/913 - (40%)	Gaps:	319/913 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 PSDPPAVSSQLDYIYLQ------DGGQE---QGQEQSDEVVHISSTRLPSIP-----ERSAAAAA 605
            |||..||..|: .:.||      .||..   :|..:::..|:..|.  |..|     |..|....
Human   123 PSDTDAVRGQI-VVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSG--PGRPLSCFMEEPAPYTD 184

  Fly   606 AAAAAAAGA-----------------ALMEPGTGTVSGS-----SGAGAAGEPPLPPAWEARMDS 648
            :..|||.|.                 .|..|   .|.||     :.......|.||..:|.|...
Human   185 STGAAAGGGNCRFVESPSQDQRLQAQRLRNP---DVRGSLQTPQNRPHGHQSPELPEGYEQRTTV 246

  Fly   649 HGRIFYIDHTTRTTSWQRPG-AAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTS 712
            .|:::::...|..::|..|. .:|||...|.:                       ||.||
Human   247 QGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGD-----------------------AAFLY----- 283

  Fly   713 ANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCF 777
                                         :|....||:|.
Human   284 -----------------------------EFLLQGHTSEP------------------------- 294

  Fly   778 QRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHR 842
                  :||.: ||  ......||..||.:...||:.:|:||.:|.|.|.||||        .|.
Human   295 ------RDLNS-VN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL--------HHI 342

  Fly   843 QQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHN 907
            ..|..|...                                |..|.|.||..|...
Human   343 MNHQCQLKE--------------------------------PSQPLPLPSEGSLED--------- 366

  Fly   908 CNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHT 972
                                             |::|....|
Human   367 ---------------------------------EELPAQRYE----------------------- 375

  Fly   973 MSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRA 1037
              |.|.:|:.:||           |:|.|                   :.||..
Human   376 --RDLVQKLKVLR-----------HELSL-------------------QQPQAG----------- 397

  Fly  1038 PPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLW 1102
                                         ..::.:.|..:.|:::|:||....|||:: ||.|.:
Human   398 -----------------------------HCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKF 432

  Fly  1103 DTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLG 1167
            ..||||||||.:||:.:||..|:.|||||||:||.::.|.:|::|.|:...:...:|.|.||::|
Human   433 RGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMG 497

  Fly  1168 LALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEE 1232
            ||:.|.:.::..||.||||.||..|:.||||||:|.|.|:||.||.:|||...:|  .||||...
Human   498 LAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLD--HTFCVEHN 560

  Fly  1233 LLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDA 1297
            ..|.::..||||.|:|:.:.|:|||||:...:.||..||::.|..:|.:||.|:|...|:..||.
Human   561 AFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ 625

  Fly  1298 RELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPY 1362
            :||||:|.|..:||.|||:.||..:....|:: ::.||||.:|.|..|:|.||||||||::.:|.
Human   626 KELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689

  Fly  1363 EGFSALRGST---GPRRFCIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF 1423
            :||.||:|||   |||.|.|... ...:.||:|||||||:|:|||.:.|.||||||.|||||..|
Human   690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754

  Fly  1424 GIE 1426
            .:|
Human   755 AVE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/28 (25%)
		HECTc	1068..1424	CDD:238033	169/359 (47%)
		HECTc	1092..1423	CDD:214523	163/334 (49%)
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..237		6/46 (13%)
		WW	236..267	CDD:197736	8/30 (27%)
		WW	307..339	CDD:197736	14/31 (45%)
		HECTc	399..754	CDD:238033	169/358 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810