DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and plekha7a

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	1442	Identity:	248/1442 - (17%)
Similarity:	385/1442 - (26%)	Gaps:	597/1442 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 QQQLGACALPQP----SEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDG 177
            |.|.|...|.||    ||||.|                          .|.|..:|.:||.||..
Zfish    99 QDQPGGRMLKQPSSTISEASTT--------------------------VTTSTVDSTSGSKGSRS 137

  Fly   178 GSSVGGGARR--------------KSWTLSPQSG-----------------------------GS 199
            ...|....:|              :.|.....|.                             ||
Zfish   138 SGRVHSFGKRDHAIKRNPSXPVVVRGWLYKQDSSGMRLWKRKWFVLADFCLFYYKDSREESVLGS 202

  Fly   200 TPLSG----------------AKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSM 248
            .||..                |.|...||..|...|....:..|.||
Zfish   203 IPLPSYTIAPVGPEDHISRKYAFKAEHTGMRTYYFSADTQEDMNGWV------------------ 249

  Fly   249 AEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQH------LRQPSPPQHRPLER 307
                               ..:..||.:|  .|..:|.:..|..|      |::.:.||...:..
Zfish   250 -------------------RAMNQAALMQ--THTVKRDECGHPDHVNVSEKLKKQAVPQTNHINS 293

  Fly   308 SWPPRAVGRDLKLQGDVFQFDILDTDER-----------LAEEMAQGSGSSNNS---------PL 352
            ...|:.         :|.|.|.|..|:|           ...||.|..|.|..|         |.
Zfish   294 YVIPKP---------EVIQSDGLPEDKREGFVGEVEIQVTPREMEQARGKSPASRVVEVEVLAPG 349

  Fly   353 ATPPVRFKPLLKKKIGPDSYINT---ISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLR 414
            :|||.|.     ....|...::|   :.....|:.|         :...|....:..|.|.|...
Zfish   350 STPPSRV-----ASRAPSRAVSTPPVVQRNGTPIEQ---------NGMPGCQRGATPSAQTPVQV 400

  Fly   415 QHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVG 479
            |.|.....:.|......||:..                           .:|.|...|.|
Zfish   401 QRRSTLEQVENWVKVQKEERHG---------------------------LVSTESTVPRR----- 433

  Fly   480 GALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTA 544
                  .||..|.:......|.|.|                :....||.|.|.
Zfish   434 ------TPPIHPKYGTMDKYQSLPK----------------TSRQSPPAPHHQ------------ 464

  Fly   545 NSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQ------------EQSDEVVH---ISSTRLP 594
                     :||:......:|::.....|..::..            :|..:..|   .:....|
Zfish   465 ---------LPSEYKYSHDRLNHFQKIHGHTKRPTTHDNTVWQLFEWQQRQQFRHGSPFAPVYTP 520

  Fly   595 SIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTT 659
            : |:.|.|.::.........::..|.|         .|...||.||.  ||:.|..|    .||.
Zfish   521 A-PDYSTAVSSTRNNPDVSRSVSVPPT---------LADIPPPGPPG--ARLMSPRR----PHTP 569

  Fly   660 RTTSWQRP-------GAAPSGGPAGREQHHRQQLDRRYQSI---RRTITNESRAAQLYNLPTSAN 714
            ......||       ...||..|      ||.   |.|:|.   ||::...:......:.|:...
Zfish   570 AERVTVRPLEDRPIVEVPPSNSP------HRL---RSYKSATIERRSMPPSAYITHTVSAPSLRG 625

  Fly   715 SNANST-----------------------APAAPPPA--TAIHPAILMLCRPDFYSLLHTNEAAL 754
            ..|:.|                       .||.|...  :.:...:..||..|  .:|...|..|
Zfish   626 KTADDTYMHLKKGLEYLDLKVSGTEALKGRPAKPVKVAESDVDVTLSRLCEQD--KILQELEFRL 688

  Fly   755 AIYNRNAALK-------------HMVMRIRRDPP------CFQRYQYNKDLVALVNTFAQMSREL 800
                  :.||             |..|...:|.|      .:|:....:|||.:....:::|.|:
Zfish   689 ------SGLKDDKDKLESVLDVSHQQMEQYKDQPSHTDKIAYQQRLLQEDLVHIRADISRVSTEM 747

  Fly   801 PSCWETKLDQSGKQFFIDH-----QHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLV 860
            ...|:   |.||.:..::.     |.:.|....|:...:..|.:...:......||....:...|
Zfish   748 ERAWD---DYSGMEQSVEQLRDVLQTQMTLCTSPQEKNQLKRELWRMEDVMTGLSSTKETFKITV 809

  Fly   861 D-------------------GNCLSATSGHINASPASSVSGVP--------------PLP----- 887
            |                   ..|::.::..:. ||..|::..|              |:|
Zfish   810 DSVKNPERKLVPSVIESTVPSRCMTPSAAEVR-SPQRSLTSSPLSLPLDNEDLRNRHPVPNWEED 873

  Fly   888 --PPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNE- 949
              ||||                                                  .:|:.|:|
Zfish   874 DAPPRP--------------------------------------------------PLPLLYDED 888

  Fly   950 --KVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEI 1012
              .|:..|  |....::|     ||..|.|:.:.:..:.:...:.....:.|:|...||  |.|:
Zfish   889 TPPVVPPL--PKETSVIR-----HTSVRGLKRQSDERKRDRESSYSNGDYRLELRSYLS--EPEL 944

  Fly  1013 -----------MGFVPIEERSPQGSPVLNSRMPQR--APPPFRRDFE-----------AKLRSFY 1053
                       .|::.::.|...||   :||:.|.  |....|||.|           .:|.|..
Zfish   945 PVSAHGADHVDPGYLTLQRRGLSGS---SSRINQYGVASCSLRRDLELSTMERPKSALERLCSGE 1006

  Fly  1054 RKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFF 1118
            .:||.:..   |.::::.:      |:...|        ::|.:.|::.:.:..|..|..
Zfish  1007 PQLEQQSQ---PQRVRMSV------EEQLER--------MKRHQRALVRERKRNLSQGER----- 1049

  Fly  1119 FLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-----DWFRFSGRVLGLALVHQYLLDA 1178
                           .:|...|..|...|.||.....|     :|.....|
Zfish  1050 ---------------HHSRASTRPVNSDPGSALFVEPHRPASDEWLTVRAR-------------- 1085

  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELK 1243
                         ||..|:||.||.||          ||...:.......:.:.|:....|.:..
Zfish  1086 -------------PVMESELEPLDFEF----------DITRELSTPQKVWIPQRLIDDESDEDPS 1127

  Fly  1244 PGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTA 1308
            |       .||..:......||..|.:.....:|.:                |..:|:|.:....
Zfish  1128 P-------EEKETRSRTVAKIKTLLSKSSMRSSEQM----------------DFSDLDLALQQQE 1169

  Fly  1309 EIDTNDWRLNTE 1320
            .|.:....|.||
Zfish  1170 RIMSVPRALATE 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	8/28 (29%)
		HECTc	1068..1424	CDD:238033	42/258 (16%)
		HECTc	1092..1423	CDD:214523	40/234 (17%)
plekha7a	NP_001129715.1	WW	55..84	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148		19/74 (26%)
		PH_PEPP1_2_3	153..256	CDD:270068	15/139 (11%)
		PH	159..255	CDD:278594	15/132 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384		9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467		14/91 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577		18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928		22/155 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064		6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900