Protein Alignment Hecw and kmr

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_061508792.1
• Gene: kmr / 5667264
• VectorBaseID: AGAMI1_001097
• Length: 2966
• Species: Anopheles gambiae
• Alignment Length: 1341
• Identity: 244/1341 - (18%)
• Similarity: 402/1341 - (29%)
• Gaps: 475/1341 - (35%)

  Fly    32 RLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEV 96
            ::||::|.....:::::::......|:                               :.|.::.
Mosquito   291 QIQQQQQHHQQQQQQQQQQLQVHKHPQ-------------------------------YPSQAQQ 324

  Fly    97 EEHEPPLASRNQEVAEVEEQQQQLGACALPQPSE----------ASLTGSKETREPRHHQTLLST 151
            ::.:..|| :.|:..::::||||....|:.|..:          |:.:||:....|  ..:|...
Mosquito   325 QQQQKQLA-QQQKQQQMQKQQQQQMQHAMKQQQQQQQQQQQRYAANGSGSQHRNAP--PSSLNLQ 386

  Fly   152 KSCETPANNAT----LSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTG 212
            ..|: ||.:.|    .|...||.|::.|......||....:..:|..|..|....:|.......|
Mosquito   387 NHCQ-PAASETDKMMRSHVPSYQGTLDSGAAGGAGGAYGEEGESLYLQRAGYQQHAGMANSPPGG 450

  Fly   213 APTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQ 277
            |.:..:...|               :|.::|:.....::...|                    |.
Mosquito   451 AGSEIIIQQN---------------IPGQVVNQACQTQISSMV--------------------LA 480

  Fly   278 ASAHVQRRQQQQHHQHLRQP----SPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAE 338
            .|::...:||||..|....|    |.|.|                            |:.||  :
Mosquito   481 GSSNAAGQQQQQQQQMKSSPSDTLSSPSH----------------------------DSSER--K 515

  Fly   339 EMAQGSGSSNNSPL----ATPPVRFKPLLKKKIGPD-------------SYI----------NTI 376
            ..|.|...:..||:    |..||.....|.|: |.|             .|:          ..:
Mosquito   516 RSAGGQQHTLKSPVTRRPANAPVALAGWLYKQ-GSDGLKVWRRRWFVLSEYVLYYYKGQEEEKLL 579

  Fly   377 STQKVPVHQSYEFPT-FPSSSAVGSSSSSPNSLQFPYLRQH---RPLTRALSNGKASSSEEQASP 437
            .|..:|   ||:... ||.....         .:|.:..:|   |....|..:|::.|...:|
Mosquito   580 GTVLLP---SYKVSACFPEDKIY---------RKFAFKCEHANMRTFVFAAESGESMSQWVRA-- 630

  Fly   438 RLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRL 502
               |:.......|:|.....:.........:|:|..:..|.|..|..:...|.|..||.....:|
Mosquito   631 ---LTLATMMIQPAGAEQEESLSQQQQQQQQQYSSGKAGGTGTELLSSDSSGGPQSHGSNDTMKL 692

  Fly   503 LKRVGGGAGAGATGGATG------------SPLV--CPPTP------------THHARRHARL-Q 540
            :::..|...:.::||..|            .||.  .||.|            ..|...|.|. |
Mosquito   693 IQQASGNGSSSSSGGGGGGVSALNDSMSMPQPLYANAPPKPRRVNDGGYSSPSPEHTMLHDRYDQ 757

  Fly   541 AVTANSSLASGGAIP-------SDPP-------------AVSSQLDY---------IYLQDGGQE 576
            .|.....||:||..|       |.||             |:::...|         :|:|...::
Mosquito   758 MVQQQQMLATGGPFPPGAVGGGSGPPNGGMVLGSSRTPAALTAHAIYGDPKRIERDLYIQKLIEQ 822

  Fly   577 QGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPA 641
            |.|:|.    .:::::.....::........::...|..::.         ||.||...|.|.|:
Mosquito   823 QQQQQQ----KLNASKQQQQQQQQQQQQGMQSSPMHGGGVLR---------SGGGAGTNPFLYPS 874

  Fly   642 WEAR----------------MDSHGRIFYIDHTTRTTSWQRPGAAPSGG--PAGREQHHRQQLDR 688
            .:.|                |..:..|:.:...:::.......||..||  |||...:.|.....
Mosquito   875 NDRRTPDTYGPPNSAIDPKHMSDYEDIYNLTMLSKSLPANAMEAAAGGGGVPAGGTTYKRPSSPL 939

  Fly   689 RYQSIRRTITNES----RAAQLYNL--------------PTSANSNANSTAPAAPPPATAIHPAI 735
            ||:.      |.:    ..|.:||.              |..|...|....|:.|.|.:|
Mosquito   940 RYEG------NGAFPAYMGAAIYNAGQFEHQSPGAAGQHPQHAQMRARPIPPSIPRPHSA----- 993

  Fly   736 LMLCRPDF--YSLLH-TNEAALAIYNRNAALKHMVMR------IRRDPPCFQRYQYNKDLVALVN 791
                  ||  |...| .|:||..:.:..:.: |...|      |.|.|   ..|.|::      .
Mosquito   994 ------DFLDYEARHPMNQAAGGVTDEPSPV-HRTPRPKSSLDINRTP---DHYYYSE------A 1042

  Fly   792 TFAQMSRELPSCWETKLDQSG-----KQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSS 851
            ::|:..|...:.:..:.:..|     ||...|.|....|...||
Mosquito  1043 SYAEKMRLQSASYLQRTNNPGAGASRKQRSDDMQGLFVSGTMPR--------------------- 1086

  Fly   852 VGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLP------PPRPSSSSSSSRSSHGHGHNCNT 910
                     ||...|. ||.|....||...| ...|      .|||   |::...:.|.|....|
Mosquito  1087 ---------DGLYRSG-SGKIMQLQASGQQG-EDYPHGGSQSMPRP---SATDHRTGGTGQGRPT 1137

  Fly   911 TSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQ------- 968
            .|::.....|.:.....|..||| ......||..:...|:    .|:.::..:|..:|
Mosquito  1138 VSSLKKQGTAQQQQEQFARSASA-RLPRKEEDSSLRDGER----KREESMKRLLEWKQRMLQSPL 1197

  Fly   969 -----GQHTMSRQLREKINILRVEGVPALERLGHDL--------------------------QLT 1002
                 .||..:....|.:|......|...:|...|:                          .||
Mosquito  1198 TKKIASQHAATMASAESLNRGSNASVGGADRRNEDIYGLKADAEALLRGDYYASSYERQSVGDLT 1262

  Fly  1003 ILLSLF------------------------------------EQEIMGFVPIEERSPQGSPVLNS 1031
            .|.|:.                                    :::...|.|....||...|.|.|
Mosquito  1263 ALSSVTAARKHGGSAVNIAQASSSAFGSQMKLNGDYNSYSSDDEDGRNFTPAGRSSPLLLPPLAS 1327

  Fly  1032 ---------RMPQRAPPPFR------------RDF---------------EAKLRSFYRKLESKG 1060
                     ..||...||..            |:|               .|..:|||......|
Mosquito  1328 TASAQEVADEAPQPPQPPHNLTPHTPPHCHQFREFPPAGSSTTDNNNSTMHALTQSFYADPAGTG 1392

  Fly  1061 YGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVL 1101
            .|:|      :.||....:|...|......:::::|:.|.|
Mosquito  1393 GGEG------NARRMLRKDDGTDRNGPPIAQEVEQGQSAGL 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	42/200 (21%)
		WW	638..667	CDD:459800	5/44 (11%)
		HECW1_helix	738..794	CDD:465766	14/64 (22%)
		HECTc	1068..1424	CDD:238033	7/34 (21%)
kmr	XP_061508792.1	None