DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and trip12

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	2206	Identity:	415/2206 - (18%)
Similarity:	634/2206 - (28%)	Gaps:	929/2206 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAASSACLADRSPVD-PIAVRLQQEE--QAEGDDEEEEEEEEDDDDDPKEEEAFYEARNGNESDE 74
            |..|....|...|:| .:|.|||.|:  |......|...........|......| || |:.|..
Zfish    13 LRRSQRNTAAAQPIDHTLAGRLQPEQVNQKANSPPENRRSNSKASKAPPSSAVGY-AR-GHTSRR 75

  Fly    75 LEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQ--------QQLGACALPQP--- 128
                        |.:.:||..:...:|.|     |.|....||        :.|...::.:|
Zfish    76 ------------NSLSLSVGSLSIPDPDL-----EAAGTSGQQGRREGSSTRALKRSSVSEPNIT 123

  Fly   129 ----------------SEASLTG------SKETREPRHHQTLLSTKS-----CETPANNATLS-P 165
                            |::|.:|      |.|..|||.....:||||     ...||....|| .
Zfish   124 FSPSPAKRPKVVSSHFSDSSASGPSAPAISPEVTEPRKAPASVSTKSKKRRLAAEPAPARALSKK 188

  Fly   166 TNSYNGSIGSDGGSSVGGGARRK----------SWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSN 220
            ::||.   |..|.||.....|:|          |.:|...|..:.||....:.::...||...|.
Zfish   189 SSSYP---GPSGASSTPSQKRKKADATLLSSSSSSSLPSSSSAAGPLPPRSEASRAAKPTKLASK 250

  Fly   221 ANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRR 285
            :...      |:....||    .|:.|.:.      ......:::..:..|..:.....|.:::.
Zfish   251 SAAS------AKAGCSTV----TDSSSSSA------SSSSSSSSSSSAATGTNSCAPQGARLKQG 299

  Fly   286 QQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSN-- 348
            :.|...:..|..|.|.         ||...||                    :|.::.:|||.
Zfish   300 KDQSKARRSRSASSPS---------PRRSSRD--------------------KEQSKAAGSSKFD 335

  Fly   349 -----NSPLATP------PVRFKPLLKKKIGPDSYINTI-----STQKVPVHQSYEFPTFPSSS- 396
                 ||.:..|      |...|.....|.||......:     ||:|.......|.|:...|:
Zfish   336 WASRFNSKVNLPKPKLSLPGSAKAETSSKPGPSGLQAKLASLRKSTKKRSESPPAELPSCRRSTR 400

  Fly   397 --AVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLL----------LSPKRPRSP 449
              ..||.:|:..              |....||..::|.:...::.          .|..|....
Zfish   401 QKTTGSCASTSR--------------RGSGLGKRGAAEARRQEKMADSDNNQDGANSSAARTEET 451

  Fly   450 PSGCSTRS--ASPLDISLSPEQHSPTRGRGVGGALQDA--VPPGTPTFHGQRPQQRLLKRVGGGA 510
            |.|.|..|  |..:.::.|.|..|.....|...||.:|  :||......|.|..|...:.:|.||
Zfish   452 PQGASASSSVAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPFGPRMSQLFHRTIGSGA 516

  Fly   511 ---------GAGATGGAT----------------------GSPL--VCPPTPT-----------H 531
                     |..|||..:                      |.|:  |.|...|           :
Zfish   517 SSKAQQLLQGLQATGDESQQLQAAIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMN 581

  Fly   532 HA-------------------------------------------------RRHAR--LQ----- 540
            ||                                                 |||::  ||
Zfish   582 HASRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQFIDVAEQALTALEMLSRRHSKAILQAGGLA 646

  Fly   541 ------------------AVTAN------------------------------------------ 545
                              |:.||
Zfish   647 DCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARL 711

  Fly   546 -----------SSLASGGAIPS-------DPPAVSSQLDYI------------------------ 568
                       ..:||...:.:       .||.:||.:..:
Zfish   712 VDNFQHEENLLQQVASRDLLTNIQQLLVLTPPVLSSGMFIMVVRMFSLMCSNCPCLAVQLMKQNI 776

  Fly   569 -----YLQDGGQEQG-QEQSD----------EVVHISSTRLPSIPERSAAAAAA-----AAAAAA 612
                 :|..|..... |||.|          |:..:....:|.:|.....|..|     :|....
Zfish   777 AETLRFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPREGIFAVDAMLKKGSAQTTE 841

  Fly   613 GA--------ALMEPGTGTVSG-SSGAGAAGEPPLPPAWEARMDSHGRIFYID---------HTT 659
            ||        .|..|.....|. ...|...||.      |..:.:.||::.||         .|.
Zfish   842 GAIWQWRDDRGLWHPYNRIDSRIIETAHQNGED------EISLSTLGRVYTIDFNSMQQINEDTG 900

  Fly   660 RTTSWQR---PGAAPSGGPAG----REQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNA 717
            ...:.||   |.|.|:.|  |    |.:..|.||.:....:.:... ::....||.:.:|
Zfish   901 TARAIQRKPNPLANPNTG--GHLEVRREDARAQLMKEDPELAKCFI-KTLFGVLYEVYSS----- 957

  Fly   718 NSTAPAAPPP------------------------ATAIHPA-------------------ILMLC 739
             |..||....                        |.:.|.|                   |||..
Zfish   958 -SAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAVSSHIASMLSSQDLKIVVGSLQMAEILMQK 1021

  Fly   740 RPDFYSLLHTNEAALAIYNRNAALKHMVMRIRR------DPP--CFQ------------------ 778
            .||.:|          :|.|...:.|.|..:..      .||  |..
Zfish  1022 LPDVFS----------VYFRREGVMHQVKNLAESEVFLTSPPKACTSGTASLCTTTITTATTTAA 1076

  Fly   779 ----------RYQYNKDLVALVNTFAQMSREL----------------PSCWETKLD-------- 809
                      .:|::.|....::...::|..|                |...:.|:|
Zfish  1077 SNVTPDLGSPSFQHSMDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTT 1141

  Fly   810 -QSGKQFFI------------------DHQHRRTSFMD--PRLPVECPR--VVRHRQQHS---QQ 848
             ||.|..|:                  :.:..||:.:.  .|:|   |:  |..:|.:..   ::
Zfish  1142 TQSPKSSFLASLNPKTWGKLGTQANSANSEPSRTAGVSGLARVP---PKDSVSNNRDKIKAWIKE 1203

  Fly   849 QSS---VGYYYPDLVDGN--------------------------CLSATSGHINASPASSV---- 880
            |:|   ..|:..:.|||:                          ||...|..::.|..||.
Zfish  1204 QASKFVERYFNSESVDGSNPALNVLQRLCTATEQLNLQMDSGVECLEEISSIVSESDVSSFEIQH 1268

  Fly   881 SGVP--------------------------------PLP---PPR-------------------- 890
            ||:.                                |:|   ||.
Zfish  1269 SGLVKQLLLYLTSNSERDTISRDERIKRFLHVFFGCPIPGQEPPGRLDPTENGPLLALVHKMNNC 1333

  Fly   891 --------------PSSSSSSSRSSHG------HGHNCNTTSAISCA---------LNADRSA-- 924
                          ||.:.:.||.|..      |...|.......|.         :..|..|
Zfish  1334 LSQMEQFPVKVHDFPSGNGNGSRGSQALKFFNTHQLKCQLQRHPDCTNVKQWKGGPVKIDPLALV 1398

  Fly   925 -----------YG----------------------AAGMASAGATA------AGYEDVPIAYNEK 950
                       ||                      ||...::|:..      .|...:|  ||..
Zfish  1399 QAIERYLVVRGYGRIREEDEDSDDDGSDDEIDESLAAQFLNSGSVRHRLQFYIGEHLLP--YNMT 1461

  Fly   951 VIAFLRQPNILEILRERQG----------------QHTM-SRQLRE------------------- 979
            |...:||.: |:...||:.                .||: .:.:||
Zfish  1462 VYQAVRQFS-LQAEEERESTDDEANPLGRAGIWTKTHTVWYKPVREDEEGCKDAVGGKRGRAQTA 1525

  Fly   980 ----------KINILRVEGV------------------------PALERLGHDLQLTIL--LSLF 1008
                      |.:.|..|||                        |::|.:   |.|.:|  :|.:
Zfish  1526 PTKTSPRNAKKQDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVI---LLLRVLHSISRY 1587

  Fly  1009 EQEIMGFVPIEERSPQGSPVLNSRMPQRA---------------PP---------PFRRDFEAKL 1049
            ...:......:|..|.|. .:||::..:|               |.         ||...|:.:.
Zfish  1588 WFYLYDNAACKEIIPTGE-FINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQ 1651

  Fly  1050 RSFY--------------------RKLESKGYGQGPH--KLKLHIRRSHLLEDAFRRIMSANKKD 1092
            ..||                    .:.:|:.....|.  :.|..|.|..||:.| ..:|    :|
Zfish  1652 MLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTINRDELLKQA-ESVM----QD 1711

  Fly  1093 L--QRGRLAVLWDTEEGLDYGGPSREFFFLLSRE---------------LFNPYYGLFE-----Y 1135
            |  .|..|.:.::.|.|... ||::||:.|:|:|               |.||..|..|     :
Zfish  1712 LGSSRAMLEIQYENEVGTGL-GPTQEFYALVSQELQRADLGLWRGEEVTLSNPKVGSQEGTKYMF 1775

  Fly  1136 SANDTYTVQVSPLS--AFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALS-- 1196
            |:...:.|.....:  |.:......|||.|:::..|::...|||.....||||.:||...::|
Zfish  1776 SSRGLFAVPFGRTTKPAHIAKIKMKFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHESSISSH 1840

  Fly  1197 DLESLDNEFHQSLQWIRD--------------------------NDIGTGV-DLGLTFCVTEELL 1234
            ||.::|....:|:|.:.|                          |..|..| ||||.|     .|
Zfish  1841 DLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNMNGCSVEDLGLDF-----TL 1900

  Fly  1235 GSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARE 1299
            ....:.|||.|||::.:...|.::||..::.|.|..||..|.||...||..|.....:..|...|
Zfish  1901 PGFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLHHLQYFYPEE 1965

  Fly  1300 LELVIAGTAEIDTNDWRLNTEYR-----SGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSS 1359
            |:.::.|:   .:..|.:.|...     .||..:.:.:.:.::|:..|..||:...||||||:..
Zfish  1966 LDQLLCGS---KSESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSPR 2027

  Fly  1360 IPYEGFSALRGSTGPRRFCIEKWGKP-NALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            :|..||.:|.......|...|....| :.||...||.|.|.||.|.:.|::.||||:|..|
Zfish  2028 LPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 2088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	8/40 (20%)
		HECTc	1068..1424	CDD:238033	118/411 (29%)
		HECTc	1092..1423	CDD:214523	111/387 (29%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915	14/70 (20%)
		HECTc	1693..2094	CDD:238033	118/410 (29%)
		HECTc	1711..2090	CDD:214523	111/387 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900