DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and smurf2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	830	Identity:	251/830 - (30%)
Similarity:	356/830 - (42%)	Gaps:	264/830 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 LPPAWEARMDSHGRIFYIDHTTRTTSWQRP----------------------------GAA--PS 672
            ||..||.|..:.|||.|::|.||:|.|:||                            |||  |:
Zfish   159 LPDGWEERRTASGRIQYLNHITRSTQWERPTRPASEYSSPGRPLSCLVDENTPIMTPNGAAGVPA 223

  Fly   673 GGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILM 737
            ..|..:|:..|.|..|.|.|  ||           :|.|             ||..
Zfish   224 DDPRVQERRVRSQRHRNYMS--RT-----------HLHT-------------PPDL--------- 253

  Fly   738 LCRPDFYS----------LLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNT 792
               |:.|.          .|||.......::         .|:.||               |.|.
Zfish   254 ---PEGYEQRTTQQGQVYFLHTQTGVSTWHD---------PRVPRD---------------LSNV 291

  Fly   793 FAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYP 857
            ..:....||..||.:...:|:.:|:||.:|.|.|.||||......|
Zfish   292 NCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLV------------------- 337

  Fly   858 DLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADR 922
                          :|.||..|.:.|......||......::|
Zfish   338 --------------LNPSPNGSRAAVEAQSSSRPGQLKEQAQS---------------------- 366

  Fly   923 SAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVE 987
                   :.|.|       ::|           ..|..|.:.:.:       |.|.:|:.|||.|
Zfish   367 -------VVSPG-------NLP-----------EDPECLTVPKYK-------RDLVQKLKILRQE 399

  Fly   988 GVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSF 1052
                                                     |:.:.||..
Zfish   400 -----------------------------------------LSQQQPQAG--------------- 408

  Fly  1053 YRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREF 1117
                          ..::.:.|..:.|:::|::|....|||.: ||.|.:..||||||||.:||:
Zfish   409 --------------HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMVKFRGEEGLDYGGVAREW 458

  Fly  1118 FFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTR 1182
            .:|||.|:.|||||||:||.:|.||:|::|.||.......:|.|.||::|:|:.|.:.:|..||.
Zfish   459 LYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTL 523

  Fly  1183 PFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGK 1247
            ||||.||..|:.|.|:||:|.:.|.||.||.|||| ||| |..||||.....|.::..||||.||
Zfish   524 PFYKQLLGKPITLDDMESVDPDLHNSLVWILDNDI-TGV-LDHTFCVEHNAYGEIIQHELKPNGK 586

  Fly  1248 NIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDT 1312
            :|.:.:..||||:...:.||..||::.|..:|.:||.|||...|:..||.:||||::.|..:||.
Zfish   587 SIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDI 651

  Fly  1313 NDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRF 1377
            |||:.||..:....|:: ::.|||:.:|.:..|:|.||||||||:|.:|.:||.||:|:.|||.|
Zfish   652 NDWKSNTRLKHCTPDSN-IVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLF 715

  Fly  1378 CIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .|.:. ...|.||:|||||||:|:|||.:.:.||:|||.|:|||..|.:|
Zfish   716 TIHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAVE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	14/28 (50%)
		HECTc	1068..1424	CDD:238033	167/356 (47%)
		HECTc	1092..1423	CDD:214523	162/331 (49%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809	14/28 (50%)
		WW	252..283	CDD:197736	5/51 (10%)
		WW	298..330	CDD:197736	13/31 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		10/80 (13%)
		HECTc	410..762	CDD:238033	167/355 (47%)
		HECTc	437..762	CDD:214523	160/328 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810