DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and yap1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001132952.1	Gene:	yap1 / 561411	ZFINID:	ZDB-GENE-030131-9710	Length:	442	Species:	Danio rerio

Alignment Length:	455	Identity:	82/455 - (18%)
Similarity:	124/455 - (27%)	Gaps:	231/455 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 LSPEQHSPTRGRGVGGALQDA------------------VPPGTPTFHGQRPQQRLLKRVGGGAG 511
            :.|.||:|..|..:.....|:                  |||..|        .||.|
Zfish     1 MDPNQHNPPAGHQIVHVRGDSETDLEALFNAVMNPKNTIVPPSVP--------MRLRK------- 50

  Fly   512 AGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQE 576
                   .......||.|..|:|:        |::...:.|.:...
Zfish    51 -------LPDSFFTPPEPKSHSRQ--------ASTDAGTAGTVTPH------------------- 81

  Fly   577 QGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGA----------G 631
                      |:             .|.::.|:...||  :.||..|..|.:.|          .
Zfish    82 ----------HV-------------RAHSSPASLQLGA--VSPGALTSMGPANAPPQHLRQSSYE 121

  Fly   632 AAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRT 696
            ...:.||||.||......|:.::::|..:||:||.|
Zfish   122 IPDDMPLPPGWEMAKTPSGQRYFLNHNDQTTTWQDP----------------------------- 157

  Fly   697 ITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNA 761
                 |.|.|         ..|..|||:|.|
Zfish   158 -----RKALL---------QMNQAAPASPVP---------------------------------- 174

  Fly   762 ALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSF 826
                                     |...|.....|..||..||..:...|:.::|:|:::.||:
Zfish   175 -------------------------VQQQNIMNPASGPLPDGWEQAITSEGEIYYINHKNKTTSW 214

  Fly   827 MDPRLPVECPRVVRHRQQHSQ----QQSSVGYYYPDLVDGNCLSATSGHINASPASSV-SGVPPL 886
            :||||.   ||...::|:.||    :|.|                   .:.:||.|.| ||..|:
Zfish   215 LDPRLD---PRFAMNQQRISQSAPVKQGS-------------------QLPSSPQSGVMSGNNPI 257

Fly 887 886
Zfish 258 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	11/28 (39%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
yap1	NP_001132952.1	FAM181	<41..186	CDD:291891	47/320 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89		9/87 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..116		5/18 (28%)
		WW	127..158	CDD:197736	13/64 (20%)
		WW	188..217	CDD:278809	9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..254		9/42 (21%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:P46937	247..442		5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900