DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and WWC3

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	1273	Identity:	237/1273 - (18%)
Similarity:	371/1273 - (29%)	Gaps:	464/1273 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTN-DVHVSVS 94
            ::.|:.|.|:.:.::..:..|||                  |.....:|....|.|. |.|...:
Human    45 IKQQRFELAQEEYQQLHKMCEDD------------------SRSYASSFSGYSTNTKYDPHQIKA 91

  Fly    95 EVEEHEPPLASRNQEVAEVEEQQQ----------------------------QLGACALPQPSEA 131
            |:......|:...:|:.:::::.|                            |.....|....:|
Human    92 EIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKA 156

  Fly   132 SLTGSKETREPRHHQTLLS---TKSCETPANNATLSPTNS---YNGSIGSDGGSSVGGGARRKSW 190
            ..||.||.|:..|....|:   ..||         |.|:|   :...:|..|.:.|
Human   157 ICTGEKERRDLMHSLAKLTDSFKNSC---------SVTDSLVDFPHHVGVPGDAGV--------- 203

  Fly   191 TLSPQ----SGGSTPLSGA---KKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSM 248
               ||    :|..|.:.|.   ..||:                               :||.:.:
Human   204 ---PQQFCDAGSQTDIIGEFVFDDKTR-------------------------------LVDRVRL 234

  Fly   249 AEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRA 313
            ....||                    |.:..|::|::..:..::               |||..|
Human   235 NWQYEE--------------------ARKRVANIQQQLARLDNE---------------SWPSTA 264

  Fly   314 VGRDLKLQ----------------------GDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPP 356
            .....:||                      |||.:.:  :..|||.||:.:...:|...  ||..
Human   265 EADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLE--EERERLEEELRRARATSAQG--ATER 325

  Fly   357 VRFKPLLKKKIGPDSYINTISTQ-----KVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQH 416
            :    ||::|      .|.:..|     ::..:...:..:..:|:...||.||..||
Human   326 I----LLQEK------RNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSL-------- 372

  Fly   417 RPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGA 481
                       |||....||.|..||              |.|..||...|:...|.   ..|..
Human   373 -----------ASSRGSLASSRGSLS--------------SVSFTDIYGLPQYEKPD---AEGSQ 409

  Fly   482 L------------QDA---VPPGTPTFHGQR-----PQQRLLKRVGGGAGAGATGGATGSPLVCP 526
            |            :||   .|||...||.||     ||.
Human   410 LLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQS-------------------------- 448

  Fly   527 PTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISST 591
                        |.::::.|||:|     ..||  ||.||
Human   449 ------------LASLSSRSSLSS-----LSPP--SSPLD------------------------- 469

  Fly   592 RLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSG-SSGAGAAGEPPLPPAWEARMDSHGRIFYI 655
             .|.:|....:..|..|.:..|     ||.|.:.. .:.|.|.|:..||..  |.:..||  ...
Human   470 -TPFLPASRDSPLAQLADSCEG-----PGLGALDRLRAHASAMGDEDLPGM--AALQPHG--VPG 524

  Fly   656 DHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANST 720
            |..........|.:||.||.....:...::|:||.:.|...:::.|.|:...........|.::.
Human   525 DGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAE 589

  Fly   721 APAAPPPATAIHPAILMLCRPDFYS---LLHT----NEAALAIYNRNAALKHMVMRIRRDPP--- 775
            .||....|:...|.|.:....|..|   |:|.    |.|.||:  :.....|:.:.:   ||
Human   590 EPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAV--KEDCKVHIRVYL---PPLDS 649

  Fly   776 ------CFQRYQYNKDLV------------ALV---------NTFAQMSREL-----------PS 802
                  |.:..::...||            ||.         :...|:..||           .|
Human   650 GTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDS 714

  Fly   803 CWETKLDQSGKQFFIDHQHRRT---------SFMDP------------------RLPVECPRVVR 840
            ..|.:|.....|.|...:..||         |..||                  |...:...|.|
Human   715 LSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVER 779

  Fly   841 -------------------HRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASP---------A 877
                               .|::...:..|...:..|.||..|.:.|    ..||         .
Human   780 ELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCT----QTSPPYPEPCCMGI 840

  Fly   878 SSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAI---SCALNADRSAYGAAG--MASAGATA 937
            .|:.|.|......|.|......|........||....   :.:|..:|.:..|.|  ...:|...
Human   841 DSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIV 905

  Fly   938 AGYEDVPIAYNEKVIAFLRQPNILEILRERQG--QHTMSRQLREKINILRVEGVPALERLGHDLQ 1000
            ......|.|.::.|....|..:....|..:..  ::|:.|:........|......:.|...||:
Human   906 RSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMARTSLDLE 970

  Fly  1001 LTILLSLFEQ-----EIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKG 1060
            |.:..|...|     |:.....:.:|....    ..|.....||...||  .:||...|:.|.:
Human   971 LDLQASRTRQRQLNEELCALRELRQRLEDA----QLRGQTDLPPWVLRD--ERLRGLLREAERQ- 1028

  Fly  1061 YGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQ-RGR 1097
                ..:.||..|.....|   :.:..|:|:..| ||:
Human  1029 ----TRQTKLDYRHEQAAE---KMLKKASKEIYQLRGQ 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	6/28 (21%)
		HECTc	1068..1424	CDD:238033	9/31 (29%)
		HECTc	1092..1423	CDD:214523	3/7 (43%)
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	16/91 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		26/136 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		10/37 (27%)
		C2_Kibra	602..725	CDD:176062	24/127 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900