DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and HERC6

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	436	Identity:	110/436 - (25%)
Similarity:	180/436 - (41%)	Gaps:	70/436 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1030 NSRMPQRAPPP------------------FRRDFEAKLRSFYRK---------LESKGYGQGPHK 1067
            |..:|...|.|                  .:.|...|::...:|         |:.|.......:
Human   619 NHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPR 683

  Fly  1068 LKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGL 1132
            ..|.:|||.|::||.|::..|...|..: .|.|.:..|...:.||.|.|||..:..|:..|.||:
Human   684 FILRVRRSRLVKDALRQLSQAEATDFCK-VLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGM 747

  Fly  1133 FEYSANDTYTVQVSPLSAFVDNCHDWF---------RF--SGRVLGLALVHQYLLDAFFTRPFYK 1186
            |.|..              :.:|. ||         |:  .|.:.||:|.:..:.:..|....||
Human   748 FMYPE--------------MGSCM-WFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYK 797

  Fly  1187 ALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIII 1251
            .||....:|.||:.|.....:|||.:.|:   ...|:|...|:...:.....|.:|.|.|.:|.:
Human   798 KLLDQKPSLEDLKELSPRLGKSLQEVLDD---AADDIGDALCIRFSIHWDQNDVDLIPNGISIPV 859

  Fly  1252 NEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWR 1316
            ::.||::|:.:.|.:.....|:...|...||||.|.:..::..|...||...|.|..:.|...:.
Human   860 DQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFE 924

  Fly  1317 LNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSAL----RGSTGPRRF 1377
            .|::|..||..:|..|..||:...:.:.:::.:.|.|:||...:...|...:    |
Human   925 QNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFR-------- 981

  Fly  1378 CIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF 1423
            |.|.:.:.:. |.:.||.|.|.||.|.|.|.:.|.|.:|:.....|
Human   982 CPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	101/371 (27%)
		HECTc	1092..1423	CDD:214523	91/345 (26%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274
		RCC1_2	89..118	CDD:290274
		RCC1	105..155	CDD:278826
		RCC1	158..208	CDD:278826
		RCC1	215..263	CDD:278826
		RCC1_2	250..279	CDD:290274
		RCC1	266..313	CDD:278826
		HECTc	684..1026	CDD:238033	100/369 (27%)
		HECTc	711..1026	CDD:214523	90/342 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810