DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	1256	Identity:	213/1256 - (16%)
Similarity:	361/1256 - (28%)	Gaps:	434/1256 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 TLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKK---- 207
            |:.|.:..|.|.  :.::..::||  :.||             :.:.|.|........:||
Human   108 TMTSEEKKERPI--SMINEASNYN--VTSD-------------YAVHPMSPVGRTSRASKKVHNF 155

  Fly   208 -------KTKTGAPTTT---LSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEE 262
                   |....||...   |...:..|..||..|..          .||...:....||:|
Human   156 GKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF----------VLSDLCLFYYRDEKE--- 207

  Fly   263 AAAVESLLGA-------AAALQASAHVQRRQQ-QQHHQHLR--------------------QPSP 299
                |.:||:       .|.|.:..|:.|:.. :..|.::|                    ..:.
Human   208 ----EGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAAL 268

  Fly   300 PQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSP----LATPPVR-- 358
            .|..|::|.               .|.|.:    :::..|.|. :..:||.|    |..|.::
Human   269 VQTEPVKRI---------------TFNFRV----DKITSENAP-TKETNNIPNHRVLIKPEIQNN 313

  Fly   359 -----------FKPLLKKKIG--------PDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSS 404
                       .|.|..:|.|        |.:.||::....:|  ..||           |.|:.
Human   314 QKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLP--SEYE-----------SGSAC 365

  Fly   405 PNSLQFPYLRQHRPLTRALSNGKASSSEEQ---ASPRLLLSPKRPRSPPSGCS-------TRSAS 459
            |....     .:||:       ..||||.:   .|...|....||.:.|....       |.|..
Human   366 PAQTV-----HYRPI-------NLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQ 418

  Fly   460 PLD--ISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSP 522
            .|:  |.:...:......|||  .....:|...|:...|     ::.|...|.........|...
Human   419 QLEQWIKIQKGRGHEEETRGV--ISYQTLPRNMPSHRAQ-----IMARYPEGYRTLPRNSKTRPE 476

  Fly   523 LVCPPTPTHHAR-------------------------------------RHARLQA--VTANSSL 548
            .:|..||:.|.:                                     ||:.|.:  ...|.|.
Human   477 SICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISD 541

  Fly   549 ASGGAIPSDP--------PAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAA 605
            .:..:||:.|        ...|.|..|........::|....|........:...:|:|
Human   542 QTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDR------ 600

  Fly   606 AAAAAAAGAALMEPGTGTVSG----------------SSGAGAAGEPPLPPAWEARMDSHG--RI 652
              .:..||..|......::.|                .:...:..|..|....:.::::|.  ..
Human   601 --RSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNE 663

  Fly   653 FYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLY---------- 707
            ....|..|.|.:.              .|..::.:.....:...|.|.:...|||
Human   664 ILSHHLQRNTIYL--------------DHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKI 714

  Fly   708 NLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAAL-AIYNRNAALKHMVMRIR 771
            :|...:......|.....|....|...:..||..|  .::|..|..| .::.....|:..::...
Human   715 SLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQD--KVVHALEEKLQQLHKEKYTLEQALLSAS 777

  Fly   772 RD-------PPCFQRYQYNKDLV--ALVNTFAQMSR---ELPSCW--------ETKLDQSGKQFF 816
            ::       |...|.....:|.:  .|::|..::||   ||...|        :..:.::..|..
Human   778 QEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQ 842

  Fly   817 IDH----QHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINA 874
            :||    |.........::..|..|   |:....:|.||:.               :...|.|.:
Human   843 LDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG---------------TTEIGMIGS 892

  Fly   875 SPASSVS----------GVPPLP------------PPRPSSSSSSSRSSHGHGHNCNTTSAISCA 917
            .|.|:|.          ..||||            ||.||.|||....|.|..|
Human   893 KPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVH----------- 946

  Fly   918 LNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKIN 982
            |..::..|...|....|:...  .|..:..:|..:..:.:      :.|..|:.........:.:
Human   947 LPEEKKMYQVQGYPRNGSHCG--PDYRLYKSEPELTTVAE------VDESNGEEKSEPVSEIETS 1003

  Fly   983 ILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERS--PQGSPV--------------LNS 1031
            :::....|                      :|.||...:|  |:.|.:              |.:
Human  1004 VVKGSHFP----------------------VGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRT 1046

  Fly  1032 RMPQRAPPP-------------------FRRDFEAKLRSFYRKLESKGYG-----QGPHKLKLHI 1072
            ..|:.|...                   .||..:|.||...:.|...|..     |.|
Human  1047 ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSP------- 1104

  Fly  1073 RRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFL---------LSRELFN- 1127
              |:|.::.||...:..:.|.:..  ..:.:.:...|:..|:.|...|         .|:||..
Human  1105 --SNLRDNPFRTTQTRRRDDKELD--TAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKT 1165

  Fly  1128 ---PYYGLFEYSANDTYTVQV 1145
               .|..|||...|...:|::
Human  1166 ENISYEMLFEPEPNGVNSVEM 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/30 (17%)
		HECTc	1068..1424	CDD:238033	18/91 (20%)
		HECTc	1092..1423	CDD:214523	14/67 (21%)
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809
		WW	58..87	CDD:278809
		PH_PEPP1_2_3	164..267	CDD:270068	21/119 (18%)
		PH	170..266	CDD:278594	19/112 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900