DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Wwc2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	1181	Identity:	221/1181 - (18%)
Similarity:	376/1181 - (31%)	Gaps:	379/1181 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EARNGNESD-ELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQ---QQQLGACAL 125
            |..:|.:|. ||.:| ::.||....:..::|..|:.:..|.   |.:|:::|:   .|.:|:
Mouse   204 EKMSGGQSGYELNEA-KAILTELKSIRKAISSGEKEKQDLM---QSLAKLQERFHLDQNMGS--- 261

  Fly   126 PQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSW 190
               ||..|..|     |.:....||.::.:  |.:.|     |.:|.||....|::....|
Mouse   262 ---SEPDLRSS-----PVNSHLSLSRQTLD--AGSQT-----SISGDIGVRSRSNLAEKVR---- 307

  Fly   191 TLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEE- 254
                       ||...::.|.......:..:..||          |..|..:       ::::|
Mouse   308 -----------LSLQYEEAKRSMANLKIELSKLDG----------EAWPGAL-------DIEKEK 344

  Fly   255 ---VDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQ------HHQHLRQPSPPQHRPLERSWP 310
               ::|:|:        ||.....:..    |:|.|::      ..|||.     :.....|..|
Mouse   345 LMLINEKEE--------LLKELQFITP----QKRSQEELERLEAERQHLE-----EELMAARGSP 392

  Fly   311 PRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINT 375
            .||:...|||             |...:|:.|               :.:...|......|.:.:
Mouse   393 SRALTERLKL-------------EEKRKELLQ---------------KLEETTKLTTSLYSQLQS 429

  Fly   376 ISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSN--------GKASSSE 432
            :|:..:         :..|.|::||.:||..||.    ...|....:||:        |....::
Mouse   430 LSSSTL---------SMSSGSSLGSLASSRGSLN----TSSRGSLNSLSSSELYYSSQGDQMDTD 481

  Fly   433 EQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQR 497
            .|.....||..|....|....:|...:  ::..||.|...:...|||   ..|....||.....:
Mouse   482 YQYKLDFLLQEKGGYIPSGPITTIHEN--EVVKSPSQPGQSGLCGVG---VTASSHTTPLTEASK 541

  Fly   498 PQQRLLKRVGGGAGAGATGGATGSPLVCP---PTPTHHARRH--------ARLQAVTANSSLASG 551
            ....|..|     .:.::....|||||..   |..:|....|        ..|....|:..|...
Mouse   542 SVASLSSR-----SSLSSLSPPGSPLVLDSVFPGSSHDTSPHQFPTDFEDCELSRRFADVGLGEN 601

  Fly   552 GA-IPSDPPAVSSQLDYIYLQDGGQEQ--GQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAG 613
            .| :.||....|..|    |:|.|...  |:...:....:..    |:|:|..............
Mouse   602 QALLDSDSGGASQPL----LEDKGLSDCPGELLCEGATDVEK----SLPKRRGLHLRGDKTTRVS 658

  Fly   614 AALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGR 678
            ||..:.   :|:|.||           .:||.|...|.:..:.::....:.....
Mouse   659 AAASDE---SVAGDSG-----------VYEASMKQPGEMEDVPYSEEDVTIVETA---------- 699

  Fly   679 EQHHRQQLDRRY---QSIRRTITNESRAAQLYNLPTSAN-----SNANSTAPAAPPPATAIHPAI 735
                :.|:..||   .|....|..:.|....:::|.|:.     :...|:|..:....|.:||..
Mouse   700 ----QVQIGLRYDTKSSSFMVIIAQLRNLHAFSIPHSSKVYFRVALLPSSADVSCLFRTKVHPPT 760

  Fly   736 LMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRI--------RRDP------------------ 774
                    .|:|:.:...:|:  ..|||:...:|:        ||:.
Mouse   761 --------ESVLYNDVFRVAV--SQAALQQKTLRVDLCSASKHRREECLAGTQISLADLPFSNEI 815

  Fly   775 -------------PCFQRYQYNK--------------DLVALVNTFAQMSRELPSCWETKLDQSG 812
                         ||.:....|:              ||.|:....|:.|.||.:. |.:|.|..
Mouse   816 FMLWYNLLPSKQMPCKKNEDGNEEPGARSQQPMLDPIDLDAVSALLARTSAELLAV-EQELAQEE 879

  Fly   813 KQFFIDHQHR----------RTSFMDPRL-----------------PVECPR---VVRHRQQHSQ 847
            ::..:..:.|          |.:..:|..                 |..|||   ..:.|::.::
Mouse   880 EEEELRPERRGPGRDCLTMLREASDEPAALRESGVPLAEGSRCTEDPKPCPRGPETSQCRKEPAE 944

  Fly   848 QQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNC---- 908
            ....:....|.|||..  :.|...::::.|           .||...||.|...|....|.
Mouse   945 DPGQLPSGLPTLVDKE--TNTDEVVDSNMA-----------VRPKDRSSLSSRQHPFVRNSVIVR 996

  Fly   909 ------NTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRER 967
                  ...|...|.||  ||...::.:|                  |...|:|.......||.:
Mouse   997 SQTFSPGERSQYICRLN--RSDSDSSTLA------------------KKSLFVRNSTERRSLRVK 1041

  Fly   968 QG--QHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQE--------IMGF-VPIEER 1021
            :.  |.|:.|..:|         .|.  |...||:|.:..||..|.        :.|. ..:||.
Mouse  1042 RAVCQPTLRRTAQE---------CPV--RTSLDLELDLQASLTRQSRLNDELQALRGLRQKLEEL 1095

  Fly  1022 SPQGSPVLNSRMPQRAPPPFRRD--FEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFR- 1083
            ..||...|        ||....|  |:..|:...::.|     |...:.|..:....|:....:
Mouse  1096 KAQGETDL--------PPGVLEDERFQKLLKQAEKQAE-----QTKEEQKQDLNAERLMRQVSKD 1147

  Fly  1084 --RIMSANKKD 1092
              |:...::|:
Mouse  1148 VCRLREQSQKE 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	4/28 (14%)
		HECTc	1068..1424	CDD:238033	4/28 (14%)
		HECTc	1092..1423	CDD:214523	0/1 (0%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		9/29 (31%)
		C2_Kibra	699..822	CDD:176062	22/146 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963		14/90 (16%)
		Phage_Nu1	<1088..>1146	CDD:294991	14/70 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900