DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and UBR5

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1507	Identity:	298/1507 - (19%)
Similarity:	462/1507 - (30%)	Gaps:	566/1507 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LAEEMAQGSGSSNN---SPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSA 397
            |:.||| .|...||   .|:......|:.||...:  :...|...:..|||......||.|.:.|
Human  1439 LSVEMA-SSKKKNNFIPQPIGKCKRVFQALLPYAV--EELCNVAESLIVPVRMGIARPTAPFTLA 1500

  Fly   398 VGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLD 462
                |:|.:::|                    .|||..|...|  |.||.|..|..|::|.|..
Human  1501 ----STSIDAMQ--------------------GSEELFSVEPL--PPRPSSDQSSSSSQSQSSY- 1538

  Fly   463 ISLSPEQH-----SPTRGR-------------------GVGGALQDAVPPGTPTFHGQRPQQRLL 503
            |..:|:|.     .|.|||                   ||.|. :|        .|.::.:.
Human  1539 IIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGE-ED--------HHDEQEEH--- 1591

  Fly   504 KRVGGGAGAGATG-----GATGSP-----LVCPPTPTHHARRHA-------RLQAVTANSSLASG 551
                |...|.|.|     ...||.     |....|.:.....|:       |...|||.::.:..
Human  1592 ----GEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEA 1652

  Fly   552 GAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVH----------------------------- 587
            ||  |..||..|:.|.........:....|||::..
Human  1653 GA--SSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQ 1715

  Fly   588 --ISSTRLPSIPERSAAAAAAAAAAAAGAALMEPG----TGTVSGSSGAGAAG------------ 634
              :.:|:.......:.::.:..||::||...::|.    :||:|.|:.|.||.
Human  1716 WAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTS 1780

  Fly   635 ---------------------------------------------------EPPLPPAWE---AR 645
                                                               |..|.|.|.   :.
Human  1781 ASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSI 1845

  Fly   646 MDSHGRIFYIDHTTRTTSWQRPGAA-PSGGPAGREQH---------HRQQLDRRYQSIRRTITNE 700
            |||            |.:..|.|:| .|.|..|...|         .|:::..|.::..||:...
Human  1846 MDS------------TEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGR 1898

  Fly   701 SRAAQL-----------------YNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLH 748
            .||..|                 .:|..|.|...:...|            :|.:|     ||.|
Human  1899 RRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLP------------VLDVC-----SLKH 1946

  Fly   749 TNEAALA-IYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVAL--------------VNTFAQMSR 798
            ......| ||    .:|.|..:...|.|..:| :..::|:.|              .|..|.::.
Human  1947 VAYVFQALIY----WIKAMNQQTTLDTPQLER-KRTRELLELGIDNEDSEHENDDDTNQSATLND 2006

  Fly   799 E----LPSCWETKLDQSGKQ--FFIDHQHRRTSFMD-----PRLPVECP---RVVRHRQQHSQQ- 848
            :    ||:       ::|:.  ||     ||:..|.     |..|.|.|   .:....|.|..|
Human  2007 KDDDSLPA-------ETGQNHPFF-----RRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQP 2059

  Fly   849 ---------QSSVGYYYPD----------LVDGNCLS---------------------------- 866
                     :.|.|.|...          .||.|||.
Human  2060 NARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEE 2124

  Fly   867 -------------ATSGH-INASPASSV--------SGVPPLPPPRPSSS--------------- 894
                         ..|.| :.|...||:        |..|||...||..|
Human  2125 QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRW 2189

  Fly   895 ---------------------------------------------------------------SS 896
                                                                           ..
Human  2190 RLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQ 2254

  Fly   897 SSRSSHGH-GHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAY--NEKVIAFLRQP 958
            :.|..:.| |..|.||   ..|::..:..:.......:|...:.|..:..|:  |||:      |
Human  2255 TMRQLNNHFGRRCATT---PMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL------P 2310

  Fly   959 NILEILRERQGQHT-----------MSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEI 1012
            |:..|....:|.||           ..|:...:..:.|..|:.|..|...|......||:   :.
Human  2311 NLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSI---DT 2372

  Fly  1013 MGFVPIEERSPQGSP--------VLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLK 1069
            ..|.|..|.:|...|        .|..|:..|.        :|...:|..|:........|.:|.
Human  2373 RPFRPASEGNPSDDPEPLPAHRQALGERLYPRV--------QAMQPAFASKITGMLLELSPAQLL 2429

  Fly  1070 L---------------------HIRRSHL-------LEDAFRRIMSANKKDLQRGRLAV---LWD 1103
            |                     |.|.:..       |.|:..::...|:|.....|..|   |.|
Human  2430 LLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDD 2494

  Fly  1104 TEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGL 1168
            |::|.|            :..||      ::......||.:....:....||   ||..||:|||
Human  2495 TDDGDD------------NAPLF------YQPGKRGFYTPRPGKNTEARLNC---FRNIGRILGL 2538

  Fly  1169 ALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWI------RDND-IGTGVDLGLT 1226
            .|:...|......|...|.||...|...|....|...::||:.:      .|.| :.:.:||...
Human  2539 CLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFA 2603

  Fly  1227 FCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRL 1291
            ..:.:|..|..|  ||.|.|.||.:..:|..||:.:..:.|:....::...::.:|..:|:....
Human  2604 IDLCKEEGGGQV--ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNS 2666

  Fly  1292 VSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIV----WFWQVIERFSNEQRLRLLQ 1352
            :....|.:..|::.|..|::.......|.:.....:|.:.::    |||.::|:.|..:|..|:.
Human  2667 LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVY 2731

  Fly  1353 FVTGTSSIP--YEGFSALRGSTGPRRFCIEKWGKP---NALPRAHTCFNRLDLPPYPTPELLYEK 1412
            |.|.:.|:|  .|||..:...|          .:|   ..||.|:||.:||.:|.|.:.::|.:|
Human  2732 FWTSSPSLPASEEGFQPMPSIT----------IRPPDDQHLPTANTCISRLYVPLYSSKQILKQK 2786

  Fly  1413 LLLAVEETNTFG 1424
            ||||: :|..||
Human  2787 LLLAI-KTKNFG 2797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/31 (23%)
		HECTc	1068..1424	CDD:238033	96/402 (24%)
		HECTc	1092..1423	CDD:214523	88/349 (25%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740		47/245 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		1/24 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		15/71 (21%)
		PolyA	2389..2452	CDD:197769	9/70 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		4/19 (21%)
		HECTc	2501..2796	CDD:214523	81/316 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900