DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and NEDD4

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens

Alignment Length:	1445	Identity:	394/1445 - (27%)
Similarity:	575/1445 - (39%)	Gaps:	382/1445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 CALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGS--SVGGGA 185
            |.|.....:|.....|.........:.|...|....:|.:.|...||: |.|||.||  |:..|.
Human   116 CILKDGIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYS-SNGSDFGSCASITSGG 179

  Fly   186 RRKSWTLSPQSGGSTPLSGAKKKTKTGA--PTTTLSNANGDGFNLWVARECFETVPAEMVDTLSM 248
            ...:..:|..|..:.|.|   ..|..|.  |:.:.||.:....|         |.|.|:....:.
Human   180 SYTNSVISDSSSYTFPPS---DDTFLGGNLPSDSTSNRSVPNRN---------TTPCEIFSRSTS 232

  Fly   249 AEVDEEVDEEEDEEAAAV----------------------ESLLGAAAALQASAHVQRRQQQQHH 291
            .:...:.|.|...|...:                      .|.....:.......:.:...|..|
Human   233 TDPFVQDDLEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSH 297

  Fly   292 QHLRQPSPPQHRP--------LERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSN 348
            |.:..||...|..        |..:.....:.:.:...|:|.....|.....|.:::.    .||
Human   298 QFIISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIV----LSN 358

  Fly   349 NSPLAT-----------PPVRF-----------------KPLLKK-KIGPDS-YINTISTQKVPV 383
            |:|..|           ..|.|                 ||.:.: |:..|| ||..       :
Human   359 NTPRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKL-------M 416

  Fly   384 HQSYEFPTFPSSSAVGSSSSSPNSLQFPYL---RQHRPLTRALSNGKASSSEEQASPRLLLSPKR 445
            |::  ....|||..|....:....|:.|:.   :.|..|.|::|.|.|
Human   417 HRT--SACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGA----------------- 462

  Fly   446 PRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGA 510
              .|...|           ||..:|:.::|                     .|.|.|:|...|..
Human   463 --YPNISC-----------LSSLKHNCSKG---------------------GPSQLLIKFASGNE 493

  Fly   511 G----------AGATG-------------GATGSPLVCPPTPTHHAR-----------RHARLQA 541
            |          ...|.             |....||.  |.||.:.|           .|.|
Human   494 GKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLY--PLPTENPRLERPYTFKDFVLHPR--- 553

  Fly   542 VTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAA 606
              ::.|...|        .:..::.|:....|.::...||::|
Human   554 --SHKSRVKG--------YLRLKMTYLPKTSGSEDDNAEQAEE---------------------- 586

  Fly   607 AAAAAAGAALMEPGTGTVSGSSGA---GAAGEP-PLPPAWEARMDSHGRIFYIDHTTRTTSWQRP 667
                      :|||...:.....|   ....|| ||||.||.|.|..||.:|::|.:|.|.|:||
Human   587 ----------LEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 641

  Fly   668 GAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSAN----------SNANSTAP 722
              .|.......|..:.|...:|..:.||.|:.|:.:..  |..:|.|          ..:|...|
Human   642 --TPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVD--NRESSENWEIIREDEATMYSNQAFP 702

  Fly   723 AAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNA------ALKHMVMRIRRDPPCFQRYQ 781
            :.||.:....|.          .|.....|.|.|:..:|      :..|...|     ...|.|.
Human   703 SPPPSSNLDVPT----------HLAEELNARLTIFGNSAVSQPASSSNHSSRR-----GSLQAYT 752

  Fly   782 YNKD--LVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQ 844
            :.:.  |..|:.|    |..||..||.|.|:.|:.:::||..|.|::..|.:     :......|
Human   753 FEEQPTLPVLLPT----SSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV-----QATVETSQ 808

  Fly   845 HSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPP-------LPPPRPSSSSSSSRSSH 902
            .:..|||.|      ......::.||.....|:....|..|       .|..||....
Human   809 LTSSQSSAG------PQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFID------- 860

  Fly   903 GHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRE- 966
               ||..||:                           :||..:    |:.|.||....|:...:
Human   861 ---HNTKTTT---------------------------WEDPRL----KIPAHLRGKTSLDTSNDL 891

  Fly   967 -------RQGQHTMSRQLREKINILRVEGV-PALERLGHDLQLTILLSLFEQEIMGFVPIEERSP 1023
                   .:..||..|......||.|.:.. |.||.:.               |.|
Human   892 GPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVA---------------ITG--------- 932

  Fly  1024 QGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSA 1088
               |.:          |:.||::.|...|.|||  |.....|:|.::.:||:.:|||::||||..
Human   933 ---PAV----------PYSRDYKRKYEFFRRKL--KKQNDIPNKFEMKLRRATVLEDSYRRIMGV 982

  Fly  1089 NKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVD 1153
            .:.|..:.||.:.:|.|:||||||.:||:|||:|:|:||||||||||||.|.||:|::|.|...:
Human   983 KRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCN 1047

  Fly  1154 NCH-DWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDI 1217
            ..| .:|:|.|||.|:|:.|..|||.||.|||||.:|..|:.|.|:||:|:|::.||:||.:||
Human  1048 EDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND- 1111

  Fly  1218 GTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRG 1282
              ..:|.|.|.:.|||.|.....|||.||..|::..||||||:..:|:||....:|:|..:...|
Human  1112 --PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEG 1174

  Fly  1283 FYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQR 1347
            |:|:|...|:.:||..||||::.|..::|.||||.:|:|::||..|||||.|||:.:....:|:|
Human  1175 FFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKR 1239

  Fly  1348 LRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEK 1412
            :||||||||||.:|..||:.|.||.||:.|.:|:||.|..||||||||||||||||.:.|.|::|
Human  1240 IRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 1304

  Fly  1413 LLLAVEETNTF-GIE 1426
            |.:|:|.|..| |::
Human  1305 LQMAIENTQGFDGVD 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	14/28 (50%)
		HECTc	1068..1424	CDD:238033	180/357 (50%)
		HECTc	1092..1423	CDD:214523	170/331 (51%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229		7/33 (21%)
		C2	<517..570	CDD:417471	11/67 (16%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		122/548 (22%)
		WW	611..643	CDD:197736	17/33 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		10/28 (36%)
		WW	769..798	CDD:395320	11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		8/48 (17%)
		WW	842..871	CDD:395320	9/65 (14%)
		WW	893..925	CDD:197736	7/31 (23%)
		HECTc	986..1315	CDD:214523	170/331 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810